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Sat Oct 17, 2020, 11:30 PM

Scitechdaily: Johns Hopkins Researchers Identify Immune System Pathway That May Stop COVID-19 Infect

https://scitechdaily.com/johns-hopkins-researchers-identify-immune-system-pathway-that-may-stop-covid-19-infection/

Blocking Immune System Pathway May Stop COVID-19 Infection, Prevent Severe Organ Damage

While the world waits eagerly for a safe and effective vaccine to prevent infections from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus behind the COVID-19 pandemic, researchers also are focusing on better understanding how SARS-CoV-2 attacks the body in the search for other means of stopping its devastating impact. The key to one possibility — blocking a protein that enables the virus to turn the immune system against healthy cells — has been identified in a recent study by a team of Johns Hopkins Medicine researchers.

Based on their findings, the researchers believe that inhibiting the protein, known as factor D, also will curtail the potentially deadly inflammatory reactions that many patients have to the virus.

Making the discovery even more exciting is that there may already be drugs in development and testing for other diseases that can do the required blocking.

Much more at link. Sounds promising!

19 replies, 2205 views

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Reply Scitechdaily: Johns Hopkins Researchers Identify Immune System Pathway That May Stop COVID-19 Infect (Original post)
SheltieLover Oct 17 OP
Takket Oct 17 #1
SheltieLover Oct 17 #2
CaliforniaPeggy Oct 17 #3
SheltieLover Oct 17 #6
Hugin Oct 17 #4
SheltieLover Oct 17 #7
Hugin Oct 18 #9
C_eh_N_eh_D_eh Oct 18 #10
SheltieLover Oct 18 #15
SheltieLover Oct 18 #12
oasis Oct 17 #5
SheltieLover Oct 17 #8
2naSalit Oct 18 #11
SheltieLover Oct 18 #13
ProfessorGAC Oct 18 #14
SheltieLover Oct 18 #17
ananda Oct 18 #16
SheltieLover Oct 18 #18
oasis Oct 18 #19

Response to SheltieLover (Original post)

Sat Oct 17, 2020, 11:32 PM

1. get a study/trial started.........

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Response to Takket (Reply #1)

Sat Oct 17, 2020, 11:32 PM

2. This!👆

Keeping fingers crossed!

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Response to SheltieLover (Original post)

Sat Oct 17, 2020, 11:35 PM

3. A big fat K&R!

Very hopeful news!

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Response to CaliforniaPeggy (Reply #3)

Sat Oct 17, 2020, 11:50 PM

6. Ikr!!!

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Response to SheltieLover (Original post)

Sat Oct 17, 2020, 11:45 PM

4. Interesting. I have a question.

This sentence makes it seem the virus actively does this for some reason, "blocking a protein that enables the virus to turn the immune system against healthy cells". I don't know why it would benefit a virus to turn the immune system against healthy cells when the virus itself needs those healthy cells to reproduce.

Maybe it's how it's worded... Would, "blocking a protein in the virus that causes the immune system to attack healthy cells" be better?

I know that the virus is not sentient and it's actions are only what occurs due to the 'program' contained in it's RNA. It's actions are really sort of a random shotgun of events that somehow ultimately produces more of the virus. It has developed over time through a colossal trial and error until some sort of a sustainable and self-replicating pattern has come about which is capable of overwhelming the immune system.

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Response to Hugin (Reply #4)

Sat Oct 17, 2020, 11:52 PM

7. Good point!

I'm not sure why it would do this & what benefit there would be to the virus.

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Response to SheltieLover (Reply #7)

Sun Oct 18, 2020, 12:03 AM

9. I think it's just a random and destructive thing the virus does in going about being a virus.

Inflammation is a huge problem.

I read through the article and I believe the way I re-worded it is correct. They say nearly the same thing down in the text.

Wow. This is fantastic! In the long term, understanding these protein pathways could be a way to treat many many inflammatory diseases from cancers to other viruses. It's probably better than a vaccine.

Here's the article's analogy:


To better understand what happens, Brodsky says think of the APC like a car in motion.

“If the brakes are disabled, the gas pedal can be floored without restraint, very likely leading to a crash and destruction,” he explains. “The viral spike proteins disable the biological brakes, factor H, enabling the gas pedal, factor D, to accelerate the immune system and cause cell, tissue and organ devastation. Inhibit factor D, and the brakes can be reapplied and the immune system reset.”



Nice. Thanks for sharing your find.



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Response to Hugin (Reply #9)

Sun Oct 18, 2020, 02:17 AM

10. Evolution doesn't "think" that far ahead.

A trait that can redirect the immune system's "attention" away from the virus would be beneficial (to the virus, that is).

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Response to C_eh_N_eh_D_eh (Reply #10)

Sun Oct 18, 2020, 07:03 AM

15. No it doesn't

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Response to Hugin (Reply #9)

Sun Oct 18, 2020, 06:52 AM

12. It sure does sound promising.

I agree this is really promising for covid & other diseases!

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Response to SheltieLover (Original post)

Sat Oct 17, 2020, 11:48 PM

5. Please be the stuff we need.

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Response to oasis (Reply #5)

Sat Oct 17, 2020, 11:53 PM

8. IKR?

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Response to oasis (Reply #5)

Sun Oct 18, 2020, 02:17 AM

11. I keep hoping for some remedial...

Therapy to help since vaccine is so far off in the distance. Treatment would be a nice change.

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Response to 2naSalit (Reply #11)

Sun Oct 18, 2020, 06:54 AM

13. It sure would!

It sounds promising for covid & other diseases as well.

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Response to 2naSalit (Reply #11)

Sun Oct 18, 2020, 06:58 AM

14. I Share That Hope

A therapeutic finding seems more likely to be quick & effective than a vaccine on a similar time line.
If people still get infected, but the death per thousand patients drops significantly, it's a huge step toward moderating the crisis.

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Response to ProfessorGAC (Reply #14)

Sun Oct 18, 2020, 07:07 AM

17. Good morning, Professor

I agree.

And, hopefully, stop the process of organ damage. Post-civid syndromes are awful.

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Response to SheltieLover (Original post)

Sun Oct 18, 2020, 07:05 AM

16. That sounds encouraging.

Thank you

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Response to ananda (Reply #16)

Sun Oct 18, 2020, 07:08 AM

18. You are most welcome!

I was excited to find this info!

Cautiously hopeful.

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Response to SheltieLover (Original post)

Sun Oct 18, 2020, 09:08 AM

19. K and R

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