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Klaralven

(7,510 posts)
Thu Mar 18, 2021, 11:12 PM Mar 2021

SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801

Abstract

All coronaviruses known to have recently emerged as human pathogens probably originated in bats1. Here we use a single experimental platform based on immunodeficient mice implanted with human lung tissue (hereafter, human lung-only mice (LoM)) to demonstrate the efficient in vivo replication of severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as well as two endogenous SARS-like bat coronaviruses that show potential for emergence as human pathogens. Virus replication in this model occurs in bona fide human lung tissue and does not require any type of adaptation of the virus or the host. Our results indicate that bats contain endogenous coronaviruses that are capable of direct transmission to humans. Our detailed analysis of in vivo infection with SARS-CoV-2 in human lung tissue from LoM showed a predominant infection of human lung epithelial cells, including type-2 pneumocytes that are present in alveoli and ciliated airway cells. Acute infection with SARS-CoV-2 was highly cytopathic and induced a robust and sustained type-I interferon and inflammatory cytokine and chemokine response. Finally, we evaluated a therapeutic and pre-exposure prophylaxis strategy for SARS-CoV-2 infection. Our results show that therapeutic and prophylactic administration of EIDD-2801—an oral broad-spectrum antiviral agent that is currently in phase II/III clinical trials—markedly inhibited SARS-CoV-2 replication in vivo, and thus has considerable potential for the prevention and treatment of COVID-19.

https://www.nature.com/articles/s41586-021-03312-w

11 replies = new reply since forum marked as read
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SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801 (Original Post) Klaralven Mar 2021 OP
Above my head but sounds good. Joinfortmill Mar 2021 #1
Seriously. Over my head, too. hamsterjill Mar 2021 #2
+1 live love laugh Mar 2021 #10
Waaay too preliminary to be conclusive Fiendish Thingy Mar 2021 #3
Sounds promising. Looking forward to further studies on this. nt crickets Mar 2021 #4
Peer reviewed (which the original journal says this is) is noce, soldierant Mar 2021 #5
Still in Phase II trials James48 Mar 2021 #6
Wouldn't it be lovely... SergeStorms Mar 2021 #7
A Tamiflu-like treatment for coronaviruses would be a great achievement Klaralven Mar 2021 #9
Hope so... PortTack Mar 2021 #8
Hopeful! But isn't it amazing that humans have figured out how to implant some human wiggs Mar 2021 #11

Fiendish Thingy

(15,366 posts)
3. Waaay too preliminary to be conclusive
Fri Mar 19, 2021, 12:09 AM
Mar 2021

Get back to me after they’ve had a peer reviewed, randomized, controlled, double blind study with human subjects.

soldierant

(6,647 posts)
5. Peer reviewed (which the original journal says this is) is noce,
Fri Mar 19, 2021, 01:09 AM
Mar 2021

but I tend to want the peers reviewed by peers of my choosing.

So I have called the attention of a friend - a retired MD who keeps his license current - to it To the journal, that is, not to this post.

And that is as far as I am prepared to go now.

James48

(4,416 posts)
6. Still in Phase II trials
Fri Mar 19, 2021, 01:15 AM
Mar 2021

And recruiting sick people for those trials . Not expected to be done with Phase II until
The end of May, if this data is correct:

https://clinicaltrials.gov/ct2/show/NCT04405739

SergeStorms

(18,882 posts)
7. Wouldn't it be lovely...
Fri Mar 19, 2021, 01:17 AM
Mar 2021

to get ahead of the SARS-CoV-2 viruses that are already in the chamber ready to pop out? This sounds miraculous. Head the next SARS virus off at the pass, so to speak, as well as cure the ones already vexing humans.

 

Klaralven

(7,510 posts)
9. A Tamiflu-like treatment for coronaviruses would be a great achievement
Fri Mar 19, 2021, 07:25 AM
Mar 2021

The experimental technique is also interesting, since it can be used to test drug effectiveness in infected human tissue in an animal model.

wiggs

(7,788 posts)
11. Hopeful! But isn't it amazing that humans have figured out how to implant some human
Fri Mar 19, 2021, 10:42 AM
Mar 2021

tissue in mice so that these kinds of studies are possible? Astonishing...

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