General Discussion
Related: Editorials & Other Articles, Issue Forums, Alliance Forums, Region ForumsSARS-CoV-2 infection is effectively treated and prevented by EIDD-2801
Abstract
All coronaviruses known to have recently emerged as human pathogens probably originated in bats1. Here we use a single experimental platform based on immunodeficient mice implanted with human lung tissue (hereafter, human lung-only mice (LoM)) to demonstrate the efficient in vivo replication of severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as well as two endogenous SARS-like bat coronaviruses that show potential for emergence as human pathogens. Virus replication in this model occurs in bona fide human lung tissue and does not require any type of adaptation of the virus or the host. Our results indicate that bats contain endogenous coronaviruses that are capable of direct transmission to humans. Our detailed analysis of in vivo infection with SARS-CoV-2 in human lung tissue from LoM showed a predominant infection of human lung epithelial cells, including type-2 pneumocytes that are present in alveoli and ciliated airway cells. Acute infection with SARS-CoV-2 was highly cytopathic and induced a robust and sustained type-I interferon and inflammatory cytokine and chemokine response. Finally, we evaluated a therapeutic and pre-exposure prophylaxis strategy for SARS-CoV-2 infection. Our results show that therapeutic and prophylactic administration of EIDD-2801an oral broad-spectrum antiviral agent that is currently in phase II/III clinical trialsmarkedly inhibited SARS-CoV-2 replication in vivo, and thus has considerable potential for the prevention and treatment of COVID-19.
https://www.nature.com/articles/s41586-021-03312-w
Joinfortmill
(14,237 posts)hamsterjill
(15,214 posts)But I like that last sentence!
live love laugh
(13,000 posts)Fiendish Thingy
(15,366 posts)Get back to me after theyve had a peer reviewed, randomized, controlled, double blind study with human subjects.
crickets
(25,896 posts)soldierant
(6,647 posts)but I tend to want the peers reviewed by peers of my choosing.
So I have called the attention of a friend - a retired MD who keeps his license current - to it To the journal, that is, not to this post.
And that is as far as I am prepared to go now.
James48
(4,416 posts)And recruiting sick people for those trials . Not expected to be done with Phase II until
The end of May, if this data is correct:
https://clinicaltrials.gov/ct2/show/NCT04405739
SergeStorms
(18,882 posts)to get ahead of the SARS-CoV-2 viruses that are already in the chamber ready to pop out? This sounds miraculous. Head the next SARS virus off at the pass, so to speak, as well as cure the ones already vexing humans.
Klaralven
(7,510 posts)The experimental technique is also interesting, since it can be used to test drug effectiveness in infected human tissue in an animal model.
PortTack
(32,606 posts)wiggs
(7,788 posts)tissue in mice so that these kinds of studies are possible? Astonishing...