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Nuclear Unicorn

(19,497 posts)
Thu Jan 28, 2016, 01:07 PM Jan 2016

Scientists open the ‘black box’ of schizophrenia with dramatic genetic discovery

Scientists open the ‘black box’ of schizophrenia with dramatic genetic discovery

For the first time, scientists have pinned down a molecular process in the brain that helps to trigger schizophrenia. The researchers involved in the landmark study, which was published Wednesday in the journal Nature, say the discovery of this new genetic pathway probably reveals what goes wrong neurologically in a young person diagnosed with the devastating disorder.

The study marks a watershed moment, with the potential for early detection and new treatments that were unthinkable just a year ago, according to Steven Hyman, director of the Stanley Center for Psychiatric Research at the Broad Institute at MIT. Hyman, a former director of the National Institute of Mental Health, calls it "the most significant mechanistic study about schizophrenia ever."

"I’m a crusty, old, curmudgeonly skeptic," he said. "But I’m almost giddy about these findings."


Scientists open the ‘black box’ of schizophrenia with dramatic genetic discovery (Original Post) Nuclear Unicorn Jan 2016 OP
Wow!!!!!!!!!! Marrah_G Jan 2016 #1
Wow, what an amazing thing it would be -- Hell Hath No Fury Jan 2016 #2
A cancer 'moonshot' and now this? randome Jan 2016 #3
Fascinating!!! valerief Jan 2016 #4


(34,845 posts)
3. A cancer 'moonshot' and now this?
Thu Jan 28, 2016, 01:35 PM
Jan 2016

The future may be closer than we think!
[hr][font color="blue"][center]Stop looking for heroes. BE one.[/center][/font][hr]


(53,235 posts)
4. Fascinating!!!
Thu Jan 28, 2016, 01:35 PM
Jan 2016
The researchers, chiefly from the Broad Institute, Harvard Medical School and Boston Children's Hospital, found that a person's risk of schizophrenia is dramatically increased if they inherit variants of a gene important to "synaptic pruning" -- the healthy reduction during adolescence of brain cell connections that are no longer needed.

In patients with schizophrenia, a variation in a single position in the DNA sequence marks too many synapses for removal and that pruning goes out of control. The result is an abnormal loss of gray matter.

The genes involved coat the neurons with "eat-me signals," said study co-author Beth Stevens, a neuroscientist at Children's Hospital and Broad. "They are tagging too many synapses. And they're gobbled up."

It also says a cure won't be found for decades. At least, now they know what they're looking for.

This link was also interesting
People with schizophrenia harbor different collections of oral bacteria than those without the mental illness, according to two new studies.
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