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(8,361 posts)
Thu Mar 3, 2022, 10:19 AM Mar 2022

Scientists develop gel that delivers drugs directly to diseased joints

Discovery could revolutionize osteoarthritis treatment

A new protein-based gel could introduce a new class of biomaterials.

March 3, 2022

Osteoarthritis (OA) is a progressive condition affecting the lives of more than 32 million Americans. Post-traumatic osteoarthritis (PTOA), a major subset of osteoarthritis that comprises 10% of diagnoses and disproportionally affects injured military personnel, has no effective therapeutic protocols that slow or stop the progression except for over-the-counter analgesics. Post-traumatic osteoarthritis leads to articular cartilage damage and results in more than $3 billion in health care costs each year.

U.S. National Science Foundation-funded researchers based at New York University identified the molecular mechanism and therapeutic payload for delivering pharmacologic treatment directly to affected joints, effectively halting the onset and progression of post-traumatic osteoarthritis. The team published its findings in Biomaterials.

The researchers combined compounds to develop a porous gel that can reach and envelop affected joints, reduce inflammation and induce regeneration. The substance, referred to as E5C, is a protein-based gel that contains native, not synthetic, cartilage components that are nontoxic and biodegradable. The properties of E5C make it a viable candidate for injectable biomaterials.

"We have developed a unique protein-based gel capable of minimally invasive, sustained delivery of prospective therapeutics in OA," said researcher and co-author Jin Kim Montclare.

NSF Public Affairs, researchnews@nsf.gov

( How awesome is that? )

Scientists develop gel that delivers drugs directly to diseased joints (Original Post) BeckyDem Mar 2022 OP
I need some for my left knee. gab13by13 Mar 2022 #1
I hope it will be available to you asap. BeckyDem Mar 2022 #2
Fantastic News JustAnotherGen Mar 2022 #3
I hope she gets her share! BeckyDem Mar 2022 #4
So only Rebl2 Mar 2022 #5
BeckyDem, thanks for this post. Progressive OA is wrecking my wife's life. NCjack Mar 2022 #6
Wonderful. I hope she can receive it asap! BeckyDem Mar 2022 #10
I suppose it will have to get FDA approval Wicked Blue Mar 2022 #7
Wheeeee !!! Karadeniz Mar 2022 #8
They've had the gel for a while now. Aristus Mar 2022 #9
That's interesting. BeckyDem Mar 2022 #11
My last encounter with it was during my orthopaedic rotation in school. Aristus Mar 2022 #12
That is a long time. BeckyDem Mar 2022 #13
Any possibility for hips, or is that a bridge too far? appalachiablue Mar 2022 #14


(64,856 posts)
9. They've had the gel for a while now.
Thu Mar 3, 2022, 05:13 PM
Mar 2022

It's called Orthovisc. It was used as a stop-gap for patients with cartilage-loss in articulating joints. It was basically the last stop before joint replacement surgery. And, IIRC, it was cripplingly expensive.

I guess now they're using it as a drug-delivery system.


(64,856 posts)
12. My last encounter with it was during my orthopaedic rotation in school.
Thu Mar 3, 2022, 07:00 PM
Mar 2022

That was twelve years ago. The price may have come down since then.

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