Mike 03Mike 03's Journal
(They have a radio station on SiriusXM)
This is one of three drugs they sound like they are getting a little bit excited about. Until recently, they have been negative on most of the ideas floating around out there, including remdesivir. The three were:
colchicine (an old gout medication, incidentally)
"Now, read whatever you want but you have to write a paper about it" so I read The World According to Garp, which I know for a fact the Alaska school board would not have approved. But the point is I could have read The Exorcist if I'd wanted to, or Naked Lunch. She just wanted us to fall in love with reading. I hope some schools still teach that way.
set up a network for mayors across the entire country, of large and small cities, to connect them to accurate information about the virus and a way to strategize, share ideas and ask questions of legitimate medical professionals.
So much of this has been in the news.
UPDATED with links
from MARCH 17, and AFTER he'd already launched his Mayors Coronavirus initiative.
Bloomberg Philanthropies Announces New $40 Million Coronavirus Global Response Initiative
Coronavirus Local Response Initiative to Begin Virtual Convenings of U.S. Mayors on March 19
NEW YORK Just days after Mike Bloomberg launched a program to help American mayors improve their coronavirus response, Bloomberg Philanthropies today announced additional actions and funding to combat the pandemic on a global scale. The new $40 million global initiative will support immediate action to prevent or slow the spread of COVID-19 in vulnerable low- and middle-income countries. Bloomberg Philanthropies will partner with the global health organization Vital Strategies on global response efforts, along with the World Health Organization (WHO), to support lower income countries and cities respond to the COVID-19 pandemic.
warning people in Los Angeles to "get the heck out of Dodge" after that not guilty verdict came down and an hour or so before the riots began.
I will be laying low, and I really fear for our country over the next several months.
EDIT: King's lawyer was Steve Lerman.
Algernon Pharmaceuticals in the spotlight with lead drug Ifenprodil as promising coronavirus therapy
Source: Proactive (The fact that two words were misspelled in the headline--which I fixed here--makes me worried about this source)
08:00 Wed 29 Apr 2020
The company has received the green light from the ministry of food and drug safety in South Korea for a Phase 2 clinical trial of Ifenprodil as a coronavirus (COVID-19) therapy
Keep in mind that all of our data has been developed from animal models that mimic or match the human disease for which we are working to develop a treatment. In our initial research stages, we were investigating Ifenprodil for a disease of the lung called idiopathic pulmonary fibrosis (IPF). We used a murine animal model that created fibrosis tissue/scarring conditions in the lungs of the mice that we were studying. Ifenprodil showed a dramatic reduction in fibrosis in the treated arm of the study. We also put Ifenprodil up against two leading human treatments and it outperformed these two drugs. This told us that the drug is active in the lung and is reducing the amount of fibrosis that can build making breathing more difficult and reducing the oxygenation capacity of the lung tissue.
An independent study of Ifenprodil in H5N1 infected mice showed that the drug reduced mortality by 40%, reduced the acute lung injury and inflammation that occurs in the lungs after being infected. H5N1 is far more lethal a form of flu than COVID-19 and so the data suggests that we may see a similar if not a stronger response in humans infected with a far less aggressive or lethal form of the flu, being COVID-19.
We believe that the mechanistic activity of the drug is lessening the inflammatory response called the cytokine storm and as a result can possibly reduce the duration and severity of a COVID-19 infection.
Read more here: https://www.proactiveinvestors.com/companies/news/918349/algeron-phrmaceuticals-in-the-spotlight-with-lead-drug-ifenprodil-as-promising-coronavirus-therapy-918349.html
NMDA receptors are multimeric ionotropic glutamate receptors composed of four subunits. GluN1 is obligate for functional expression. Other subunits include GluN2A, GluN2B, and the more recently discovered GluN3 subunits. Ifenprodil selectively blocks NMDA receptors containing the GluN2B subunit.
APRIL 29, 2020
by The Scripps Research Institute
The drug, a monoclonal antibody now owned by the pharmaceutical company Implicit Bioscience, is planned to be used in a small clinical trial taking place at four sites in Italy, Spain, Australia and Singapore.
The trial will assess whether the drug, known as IC14, can temper the immune system's response to coronavirus infection of the lungs, thus preventing dangerous levels of inflammation seen in patients with severe cases of the disease.
"Patients with severe COVID-19 often progress to acute respiratory distress, where inflammation results in lung damage and subsequent multiple organ failure," says Richard Ulevitch, Ph.D., a professor and former chairman of Immunology at Scripps Research, who originally developed the drug. "By dampening the innate immune system's response to the infection, IC14 may prevent patients from spiraling out of control and improve their chances for recovery."
The drug targets an immune system protein called CD14, that Ulevitch and Scripps Research colleagues first linked to innate immunity and inflammation in work started in the mid-1980s.
Read more here: https://medicalxpress.com/news/2020-04-clinical-trial-covid-patients-anti-inflammatory.html
This drug has been used in trials to treat Acute Lung Injury, Amyotrophic Lateral Sclerosis, Adult Respiratory Distress Syndrome. A trial on Sepsis was discontinued.
Charlotte Business Journal
By Caroline Hudson
29 minutes ago
The trial is with Selinexor, an oral drug used to treat multiple myeloma, a type of cancer in bone marrow. The anti-viral and anti-inflammatory drug has also been shown to kill the Covid-19 virus. This trial, known as the XPORT trial, spans about 15 countries, including more than 10 sites in the United States, said Dr. Zainab Shahid, medical director of bone marrow transplant infectious diseases at Levine Cancer Institute. Shahid is the trial's principal investigator.
Patients at Carolinas Medical Center, Atrium Health-Cabarrus, Atrium Health-Pineville and Atrium Health-University may be eligible to participate. They take the pill every other day and can do so at home. The trial lasts two weeks.
Shahid hopes to enroll one to two patients per week. Atrium screened its first patient on Tuesday morning, she said. Part of her role is to work with doctors to find eligible patients and then connect those patients with the clinical trial team. The trial is for patients with more serious Covid-19 symptoms they could be hospitalized with upper-respiratory issues, for example. Supportive care is more appropriate for mild cases, Shahid said.
More here: https://www.bizjournals.com/charlotte/news/2020/04/28/atrium-health-launches-first-clinical-trial-for.html
Selinexor was granted accelerated approval by the U.S. Food and Drug Administration (FDA) in July 2019, for use in combination with the corticosteroid dexamethasone for the treatment of adult patients with relapsed refractory multiple myeloma (RRMM) who have received at least four prior therapies and whose disease is resistant to several other forms of treatment, including at least two proteasome inhibitors, at least two immunomodulatory agents, and an anti-CD38 monoclonal antibody. In clinical trials, it was associated with a high incidence of severe side effects, including low platelet counts and low blood sodium levels.
Please don't ask me what "a selective inhibitor of nuclear export" is.
This is another very expensive drug:
FDA approved a myeloma drug. Some doctors say it was the wrong decision
In a series of tweets, a myeloma expert called the FDA accelerated approval of Karyopharm's Xpovio "baffling" and "incorrect" and the drug's $22,000 monthly price tag "outrageous." A member of ODAC also agreed that the drug should not have been approved so early. The company defended the drug and its pricing.
One fear I'm beginning to have is that COVID-19 clinical trials are becoming a dumping ground for expensive drugs of dubious efficacy. But hopefully I'm wrong.
This is an extract from Yanis Varoufakis' book, Adults in the Room: My Battle With Europes Deep Establishment Varoufakis was the Greek Minister of Finance during Greece's extreme financial difficulties in around 2015.
In the deep of a spring night a gentleness descends on Washington, DC that is unimaginable during the day. As the politicos, the lobbyists and the hangers-on melt away, the air empties of tension and the bars are abandoned to the few with no reason to be up at dawn and to the even fewer whose burdens trump sleep. That night, as on the previous eighty-one nights, or indeed the eighty-one nights that were to follow, I was one of the latter.
It had taken me fifteen minutes to walk, shrouded in darkness, from 700 19th Street NW, the International Monetary Funds building, to the hotel bar where I was to meet him. I had never imagined that a short solitary stroll in nondescript DC could be so restorative. The prospect of meeting the great man added to my sense of relief: after fifteen hours across the table from powerful people too banal or too frightened to speak their minds, I was about to meet a figure of great influence in Washington and beyond, a man no one can accuse of either banality or timidity.
All that changed with his acerbic opening statement, made more chilling by the dim light and shifting shadows. Faking steeliness, I replied, And what mistake was that, Larry? You won the election! came his answer.
It was 16 April 2015, the very middle of my brief tenure as finance minister of Greece. Less than six months earlier I had been living the life of an academic, teaching at the Lyndon B. Johnson School of Public Affairs at the University of Texas at Austin while on leave from the University of Athens. But in January my life had changed utterly when I was elected a member of the Greek parliament. I had made only one campaign promise: that I would do everything I could to rescue my country from the debt bondage and crushing austerity being imposed on it by its European neighbours and the IMF. It was that promise that had brought me to this city and with the assistance of my close team member Elena Paraniti, who had brokered the meeting and accompanied me that night to this bar.
Smiling at his dry humour and to hide my trepidation, my immediate thought was, Is this how he intends to stiffen my resolve against an empire of foes? I took solace from the recollection that the seventy-first secretary of the United States Treasury and twenty-seventh president of Harvard is not known for his soothing style.
Determined to delay the serious business ahead of us a few moments more, I signalled to the bartender for a whiskey of my own and said, Before you tell me about my mistake, let me say, Larry, how important your messages of support and advice have been in the past weeks. I am truly grateful. Especially as for years I have been referring to you as the Prince of Darkness.
Unperturbed, Larry Summers replied, At least you called me a prince. I have been called worse.
This is a pretty chilling story, if you haven't heard it.
Doctor Radio and are on the front line every day always sound lukewarm when they talk about Azithromycin and say they give it 1) if a secondary bacterial infection is suspected on top of the COVID or sometimes 2) in an attempt to prevent a secondary bacterial infection occurring. They are brutally honest and say they are trying certain things based on a combination of assumptions, early clinical data and drug availability. They are even having second thoughts about intubation/ventilation. They truly are not excited about anything, not even Remdesivir (and definitely not Hydroxychloroquine). They are more excited about proning and oxygen than the drugs currently being conjectured for COVID.
Every damned one of these doctors begins his/her show by saying, "I've never seen anything like this in my life."
This virus is not understood.
But the situation changes every day, and there could be a breakthrough tomorrow.
From Clin Vaccine Immunol. 2013 Mar; 20(3): 319327.
Targeting the Cytokine Storm for Therapeutic Benefit
Riccardo V. D'Elia,corresponding author Kate Harrison, Petra C. Oyston, Roman A. Lukaszewski, and Graeme C. Clark
There's also a paper about the use of nicotine to suppress cytokine production in Crohn's Disease:
In-vivo effect of nicotine on cytokine production by human non-adherent mononuclear cells. (result: Nicotine inhibits Interleukin 10)
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