Broccoli and Brussels sprouts: cancer foes

[elleng]

6. The article makes it clear that work has to be done:

'But for anyone encouraged by the results who wants to embark on a broccoli-eating binge, Pandolfi said there’s a chore ahead. The doses effective in laboratory mice would be the human equivalent of eating more than six pounds of broccoli daily.

From a practical standpoint, that means the most likely approach would be to develop a pill form, Pandolfi said. I3C seems to be well-tolerated by humans and is actually on the market based on anti-cancer properties exhibited in preliminary studies. Its targets aren’t limited to WWP1, so additional work is needed to investigate appropriate doses and unintended effects of I3C supplements, Pandolfi said.

An alternative, albeit one that will take time, would be to develop a more narrowly targeted molecule based on I3C’s structure that zeroes in on WWP1. Pandolfi said his team’s future research will likely move in those directions.'