Reply #2: There's an interesting article on it on Wikipedia

[deucemagnet]

The writers say it's all about failure. Dr. Venture was a successful boy adventurer, but he peaked at about age 15, now he's a failed super-scientist. The boys are failed boy adventurers. The Monarch is a failed arch villain and lost Dr. Girlfriend. Brock can't get past 2nd base with Molotov Cocktease, and it's implied that he's a failed secret agent. Even Jonas Venture failed when he was absorbed in the womb by Dr. Venture, and then failed to get revenge when he finally escaped.