Can they get cell phone Internet for road conditions and weather updates? There are roadhouses along the way, but the road can be bumpy, and has large truck traffic.
If they plan a little ahead, they can mile-mark the towns, roadhouses in between, and other handy stops. Also a good idea to get head lamp covers, carry at least to real tires for extra, rope, jumper cables, basic tool kit including socket wrenches, duct tape and plastic sheeting (no...not for terror alerts..lol), and, of course, extra blankets or -0 sleeping bags, food, water, de-icer for windshield, flares, and reflective triangles.
Others have done this trip...pacing and planning makes all the difference. Hopefully, the car will also have a deer bar on the front. As long as they try to drive mostly daylight for as much as they can, and set reasonable distances that include actual places to stop, they should be fine. There is a gazetter they can get that has all the mileposts
http://www.themilepost.com/ , and I think there's one for the Al-Can as well. Just make sure they know to NOT take the Stewart-Cassier (logging) Road as a short-cut...it is very desolate, and the logging trucks run and rule that road.