Study Reveals Potential Serious Cardiac Issues Related to Trump's Cure-All Hydroxychloroquine

[NoRoadUntravelled]

https://www.ncbi.nlm.nih.gov/pubmed/29858838


Note: These were not cases of Covid-19 but a study of the outcomes of treatments using Hydroxychloroquine and Chloroquine on various patients done in 2017

Snip-
"RESULTS:
Eighty-six articles were identified, reporting individual cases or short series, providing information on 127 patients (65.4% female). A majority of patients were treated with chloroquine (58.3%), with the remaining treated with hydroxychloroquine (39.4%), or both in succession. Most patients had been treated for a long time (median 7 years, minimum 3 days; maximum 35 years) and with a high cumulative dose (median 1235 g for hydroxychloroquine and 803 g for chloroquine). Conduction disorders were the main side effect reported, affecting 85% of patients. Other non-specific adverse cardiac events included ventricular hypertrophy (22%), hypokinesia (9.4%), heart failure (26.8%), pulmonary arterial hypertension (3.9%), and valvular dysfunction (7.1%). For 78 patients reported to have been withdrawn from treatment, some recovered normal heart function (44.9%), while for others progression was unfavorable, resulting in irreversible damage (12.9%) or death (30.8%)."

[Blue Owl]

1. "Go ahead. Try it. What do you have to lose?"

Time for the shitweasel to have the daylights sued out of him...

[FBaggins]

2. If we're going to be fussy about the relevance of small studies...

... then we should also be fussy about claims based on studies that are not related to the expected use of the drug.

The median patient involved in this study took the medication for several years and consumed over a kilogram of the stuff. That isn't close to the dosing that people are using in this case.

[Hoyt]

3. In study, patients had been on it median of 7 years vs a week or so for CV19.

Some patients have been taking the drug for 35 years. Dosages are much higher too.

While I get criticism of trump’s BS, don’t think that’s a valid comparison. 7 years, at high dosage, is not comparable to short-term therapy in a hospital while closely monitored.

[NoRoadUntravelled]

6. I see your point.

Thanks for clarifying.

[Hortensis]

4. Old medicine, trade name Plaquenil, lots of side effects

very well established. It's a heavy-duty drug, but most use has been long term. Guessing data for short-term use on people developing respiratory problems, most 65 and over with serious comorbid conditions that might strongly preclude its use normally, aren't available.

[zackymilly]

5. My wife has been on hydroxychloroquine (Plaquenil) since 1992.

It can cause blindness, so she has to have a retinal scan every 6 months. No problem with her vision yet, and no other side affects experienced for 28 years.
She has an auto-immune disease. Without the Plaquenil, all her joints start hurting and swelling and stiffening up.
Good thing she just got her 90-day supply refilled.