Dr. Fauci confirms Remdesivir is successful in treating COVID-19

[DrToast]

Last edited Wed Apr 29, 2020, 01:11 PM - Edit history (1)

It's not a cure, but it does seem to help.

https://sanfrancisco.cbslocal.com/2020/04/29/coronavirus-dr-fauci-gilead-covid-19-nih-test-results/

More details here:

Fauci says Gilead reports the anti-viral reduced duration of COVID-19 from 15 to 11 days. "A drug can block this virus," said Fauci about the results of the drug trial. He says the mortality rate also fell from 11% to 8%. He calls the improvement "very important."

Link to tweet

Update. Clip from Dr. Fauci:

Link to tweet

[Newest Reality]

1. With no control group?

The side effects may be an issue, as well.

Globally, it is going to be an inexpensive drug.

Well, we'll see.

[DrToast]

2. With a control group

[Newest Reality]

3. I was referring to this:

Separately on Wednesday, Gilead announced partial results from its own ongoing study of the drug in severely ill, hospitalized COVID-19 patients. The company said patients treated for five days “achieved similar improvement” in health as others treated for 10 days. However, that result is hard to interpret because there is no comparison group of people getting usual care, so it’s impossible to know how much patients would have improved on their own.

Doesn't that mean there was none?

[DrToast]

5. This article is not about that

There are two separate studies making the news today.

One comparing 5-day vs. 10-day treatment course.

The other study is a randomized controlled trial being conducted by the NIH:

The study, run by the National Institutes of Health, tested remdesivir versus usual care in about 800 hospitalized coronavirus patients around the world. The main result is how long it takes patients to recover.

[uponit7771]

8. Has the NIH study been released? tia I could care less what a pumper like Gilead says ...

... we're waiting on the full NIH study.

[DrToast]

9. Dr. Fauci is talking about the NIH study

He's not talking about the Gilead study.

[uponit7771]

6. Yes, there was no TRUE control group and no one cares what a pumper like Gilead says about

... drugs seeing they've done this before with Ebola and Rem.

We should wait on the full NIH report,

[Newest Reality]

12. Yes,

I have read their history and it is very shady. It's available online.

I wonder if the Wall St. traders bother to do that, considering the perk they got from that sketchy news?

[uponit7771]

33. Not from the Gilead study, the NIH study had one

[DrToast]

14. Yes, there WAS a control group. Please stop spreading misinformation

You can read about the study design here:

A randomized, controlled clinical trial to evaluate the safety and efficacy of the investigational antiviral remdesivir in hospitalized adults diagnosed with coronavirus disease 2019 (COVID-19) has begun at the University of Nebraska Medical Center (UNMC) in Omaha.

https://www.nih.gov/news-events/news-releases/nih-clinical-trial-remdesivir-treat-covid-19-begins

[jpak]

26. This was a double-blind placebo study

So there was a true control group

[uponit7771]

4. "Gilead reports" .. doesn't mean anything we're looking for the NIH report. I like Fauci but if

... he is truly reporting just what a pumper like Gilead is reporting thing I'm disappointed

[DrToast]

7. He's talking about the NIH study

[uponit7771]

13. This is false, Fauci is mentioning Gilead's reporting of NIH not NIH themselves. The NIH ...

... results have not been released and the NIH has not responded to inquiries.

Pumpers like Gilead play with words multiple times when it comes to drugs

Gilead — who stock was up $4.48 to $83.15 in midday trading — gave no details on results Wednesday, but said an announcement is expected soon. NIH officials did not immediately reply to a request for comment.

[DrToast]

16. OMG what is wrong with you?

It's right there in the article:

But Dr. Anthony Fauci called the NIH test results “quite good news” in a morning call with reporters.

[DrToast]

18. Here's another link!

White House health advisor Dr. Anthony Fauci said Wednesday that data from a coronavirus drug trial testing Gilead Sciences’ antiviral drug remdesivir showed “quite good news.”

Speaking to reporters from the White House, Fauci said he was told data from the trial showed a “clear cut positive effect in diminishing time to recover.”

https://www.cnbc.com/2020/04/29/dr-anthony-fauci-says-data-from-remdesivir-coronavirus-drug-trial-shows-quite-good-news.html

[uponit7771]

19. What is wrong with you ?! Link the NIH report on Rem ... go ahead I'll wait for you to run away

... like the other have this morning.

[DrToast]

20. Do you know who Dr. Fauci is?

He's the director of the National Institute of Allergy and Infectious Diseases.

He's giving a preview of the results of the study.

He's not talking about the separate Gilead report.

Otherwise I'll eat being wrong with gladness knowing the caveats are this does ... NOT ... stop people from getting the virus

Oh dear god. That's not what the drug is for. It's a TREATMENT.

[uponit7771]

21. That's not a link to the NIH study

[DrToast]

23. The study has not been released yet

But you know, the director of the National Institute of Allergy and Infectious Diseases just might be credible in talking about the results.

But hey, what does he know. I'm sure you know better.

[uponit7771]

27. No wonder cause this drug does not ***BLOCK*** the virus it lowers mortality ...

... rate by some unknown factor.

[DrToast]

30. THAT'S HOW THE DRUG WORKS

By preventing viral replication.

OMG....I'm done with you. Everything you've claimed in this thread has been disproven (there was a control group and Fauci is talking about the NIH results) and now you're just pretending you never said those things. We all can read your posts, you know.

[uponit7771]

34. Fauci said it doesn't block the virus and I could care less about your emoting, more facts please

[DrToast]

41. Please provide your source

Here's mine. It's Dr. Fauci.

Link to tweet

[uponit7771]

43. The reporter asked him if this is a vaccine Fauci said no at the end of his comments

[DrToast]

44. LOL. It's a TREATMENT. Do you know what that is?

Also, that's not a source.

Here's mine:

Link to tweet

I'll wait.

[uponit7771]

45. Deflection, never said it wasn't a treatment in my comment you're responding to. Stop playing

... word games

Again, this is DU and we're not LIVs

[LisaL]

50. Because nobody expected it to be a vaccine.

It's a drug. Not a vaccine.
Jeez.

[uponit7771]

54. This is false on its face, don't use absolutes like "nobody". The reporter wouldn't have asked the

... question if there was "nobody"

[LisaL]

48. He said just the opposite, the drug can block this virus.

[uponit7771]

39. As I claimed upthread you'll run like everyone else but you threw out strawmen first.

[uponit7771]

22. I"m looking at Fauci now, this drug does ... ***NOT*** knock out the virus !! Fuck that, who

... cares if my death date change.

I KNEW ... this was some bullshit.

[DrToast]

25. LOL

Oh....so now you admit there WAS a control group.

And you acknowledge that Fauci was NOT talking about the separate Gilead study.

So now you're trying to move the goalposts and say it's bullshit because it's not a cure, but NOBODY ever said it was a cure.

Keep digging, man.

[uponit7771]

31. Strawman noted I never said there wasn't a control group from the NIH study, keep going

[DenverJared]

10. New data on Gilead's remdesivir, released by accident, show no benefit for coronavirus patients.

“A draft manuscript was provided by the authors to WHO and inadvertently posted on the website and taken down as soon as the mistake was noticed. The manuscript is now undergoing peer review and we are waiting for a final version before WHO comments on it,” said WHO spokesperson Daniela Bagozzi.

Gilead spokesperson Amy Flood said the company believes “the post included inappropriate characterization of the study.” Because the study was stopped early because it had too few patients, she said, it cannot “enable statistically meaningful conclusions.” However, she said, “trends in the data suggest a potential benefit for remdesivir, particularly among patients treated early in disease.”

https://www.statnews.com/2020/04/23/data-on-gileads-remdesivir-released-by-accident-show-no-benefit-for-coronavirus-patients/

There had been widespread hope that remdesivir could treat Covid-19.

But a Chinese trial showed that the drug had not been successful, according to draft documents accidentally published by the World Health Organization.

The drug did not improve patients' condition or reduce the pathogen's presence in the bloodstream, it said.

https://www.bbc.com/news/world-52406261

Fauci is full of shit.

[uponit7771]

15. THIS !!!! This an older report but yeah, Gilead has done this before but Fauci is basing his ...

... statement off of what the Gilead said which is still foolish cause he hasn't read the NIH report which hasn't released yet.

[mr_lebowski]

24. Not saying you're wrong but how do you know Fauci doesn't already know what it says?

He's not just some schmo who'd necessarily have to wait for public release of something like this.

[DrToast]

28. Right?

The director of the National Institute of Allergy and Infectious Diseases just MIGHT know what the study says.

[mr_lebowski]

29. I don't know either way but I wouldn't discount the possibility out-of-hand (nt)

[DrToast]

42. Here.

Link to tweet

[uponit7771]

46. The reporting earlier on MarketWatch that Fauci replied to Gilead's reporting. The NIH report

... does show efficacy in time on sickness but the mortality drop was insignificant.

Fauci said this is a step in the right direction and not a vaccine.

[LisaL]

49. It's a drug. Nobody expected it to be a vaccine.

Drug is something that treats existing disease, vaccine is something that prevents someone from become sick.

[DrToast]

55. Thank you.

They're attacking it because it doesn't do things nobody expected it would do.

It also doesn't do my laundry! It sucks!

[LisaL]

52. Those were severely sick patients.

The drug is likely most effective when given early in the disease. It might be too late for severely ill patients.

[DenverJared]

56. The fact that it doesn't work in one set of patients

doesn't automatically mean it works in another set of patients.

That is like saying a drug works in left handed people because it didn't work in right handed people.

[LisaL]

57. We just established that a large study showed it does work.

Isn't that what we are discussing here?

[DenverJared]

58. It didn't show it works

Reduction of 15 to 11 can happen by chance. There is no control group to provide statistical significance.

Giving strawberry yogurt could also provide similar results. Doesn't mean it works.

[PCIntern]

11. No no no

It’s chloroquiniehydroxylatizine. Try haa as t’s best. Forget this... Some people like to call it that. This other stuff...I don’t know anything about it and don’t own any stock in the company. And covfefe

[Newest Reality]

17. Just for context:

Capitalists at there best. I don't think I would buy a used car from them, but maybe I'm picky. Any better companies out there working on this?

Several class-action lawsuits have been filed against Gilead over allegations that the company deliberately delayed development of antiretroviral drugs based on tenofovir alafenamide fumarate (TAF) in order to maximize profits from previous-generation medications containing tenofovir disoproxil fumarate (TDF).[63] Plaintiffs allege that Gilead suspended TAF in 2004 despite clear evidence indicating that TAF-based medications were safer than TDF, a compound whose long-term use was associated with adverse side effects such as nephrotoxicity and bone density loss.[64][65] Gilead intentionally withheld results of clinical trials demonstrating TAF's relative safety and efficacy and shelved TAF-based therapies until 2010, when the Food and Drug Administration approved Gilead's application to patent TAF.[66] Gilead's first TAF medication, marketed under the trade name Genvoya, came out in 2015. In the interim period, many HIV patients who continuously took Gilead's older TDF-based drugs suffered permanent, debilitating kidney and bone damage, often developing conditions such as Fanconi syndrome and osteomalacia.[67]

Gilead has come under intense criticism for its high pricing of its patented drug sofosbuvir. In the US, for instance, it was launched at $1,000 per pill or $84,000 for the standard 84-day course.[68][69]

Gilead has also tried to eliminate competition in lucrative markets by entering voluntary licensing agreements (VLA) with companies from developing countries such as India, which mandated the limitation of the latter's operations to less lucrative markets. The company has also been criticized for creating harsh restrictions within countries where they have been denied rights, or are engaged in VLAs. For example, in India, they tried to create an 'anti-diversion' program to determine who could buy the drug, which was considered a coercive and policing move by Médecins Sans Frontières since it could lead to the exclusion of vulnerable groups like refugees and migrants from accessing the medicines.[70]

On January 21 2020, the Wuhan Institute of Virology applied for a Chinese "use patent" on remdesivir, for the novel use of treating COVID-19.[71]

Gilead sought and obtained "orphan drug" status for remdesivir from the US Food and Drug Administration on March 23rd, 2020. This provision is intended to encourage the development of drugs affecting fewer than 200,000 Americans by granting strengthened and extended legal monopoly rights to the manufacturer, along with waivers on taxes and government fees.[72][73] Remdesivir is a candidate for treating COVID-19; at the time the status was granted, fewer than 200,000 Americans had COVID-19, but numbers were climbing rapidly as the COVID-19 pandemic reached the US, and crossing the threshold soon was considered inevitable.[72][73] Remdesivir was developed by Gilead with over $79 million in U.S. government funding.[73] After facing strong reactions, Gilead gave up the "orphan drug" status for remdesivir on March 25th.[74] Gilead retains 20-year remdesivir patents in more than 70 countries.[75]

Gilead has also been accused of price-gouging on other medications developed with public funding, including AIDS PrEP drug Tenofovir and hepatitis C drug Sofosbuvir.[76]

https://en.wikipedia.org/wiki/Gilead_Sciences

[roamer65]

32. It means lives can be saved.

Not all, but some is better than none.

[uponit7771]

36. Fauci said the mortality drop was insignificant. THAT is what we're looking at !!

[Goodheart]

35. Such bullshit.

No control group + Small sample size + Manufacturer with profit motive = I ain't buying it.

[DrToast]

37. Please stop spreading misinformation

[uponit7771]

40. Please stop giving this drug more efficacy then Fauci claimed during the presser. He said its

... direction and the lower mortality rate was insignificant.

[LisaL]

51. It's significantly shortened the duration.

[uponit7771]

53. For which level of sickness? The NIH study needs to be given

[uponit7771]

38. The ***NIH*** had a control group Gilead did not. Fauci said the Mortality drop was insignificant

... but shows there's a drug that workds

[GeorgeGist]

47. Dr. Who confirms that wearing a mask is successful in preventing Covid-19 ...

but geniuses Fauci and Brix seem unaware of this finding.