I'm just wondering why COVID-19 has proven a cinch to develop a vaccine for unlike other diseases?

[NewsCenter28]

https://www.marketwatch.com/amp/story/after-months-of-speculation-investors-get-excited-about-pfizer-biontechs-coronavirus-vaccine-candidate-2020-07-01

https://abcnews.go.com/amp/Health/early-trial-results-pfizer-vaccine-development-track-2020/story?id=71564008

This is just one of maybe 4 or 5 vaccines ready to go relatively soon that I’ve heard about. What is it about COVID-19 that has made it so easy to develop a vaccine in record time for versus other diseases that seem so resistant to vaccines like AIDS although ARVs are pretty miraculous on their own (they weren’t developed in just 2 months like the COVID-19 vaccines though).

[cwydro]

1. They've developed a vaccine?

[NewsCenter28]

2. Yep check out the ABC article above

N/T.

[soothsayer]

4. We'll see

[LisaL]

34. They are testing vaccine candidates.

Nothing has been proven to be safe and effective yet.

[C_U_L8R]

13. They've developed a way to manipulate the stock market

There is no vaccine. Maybe there will be one eventually once proven over time with science. But it won't be some Archimedes in the bathtub Eureka! moment that Trump desperately wants to claim credit for all over every screen.

[uponit7771]

32. THIS !!!! ☝🏾 I'm thinking I'm going crazy cause "the vaccine" is on all the money channels and ever

... every time there's some inflection point for a major index there's some stupid news about a vaccine that someone has to be a nut case to be the first to take looking at the last 3 out of 4 quick turnaround vaccine attempts.

Swine flue doesn't count, we already had a base vaccine for it.

There is some evil shit going on with this vaccine crap and NO ONE wants to tell America why we should trust a quick turnaround vaccine we've never developed a base for.

[Laelth]

3. Companies are rushing products to market.

They hope to make bank on a global pandemic, but that doesn’t mean that any of their vaccines are actually going to work.

-Laelth

[soothsayer]

5. This

[cwydro]

7. Yes.

I'll believe it when it happens.

[soothsayer]

6. I'd like to see large-scale, longitudinal studies that show it works and doesn't kill anyone

Those cytokine storms are worrisome.

[harumph]

15. Yes, antibody dependent enhancement is a real thing

to be concerned about.

edited to add;

https://www.nature.com/articles/d41587-020-00016-w

[soothsayer]

22. In all likelihood, the most vulnerable would not be able to take it

[dsc]

8. I am old enough to remember breathless articles about HIV vaccines

and well, we know how that went.

[Demsrule86]

9. Seriously? And I wonder who a post like this helps...hmmm

[lapfog_1]

10. number of reasons

1. Covid-19 is actually very similar to other Corona viruses which vaccine development has been underway for years.
2. Our understanding of RNA viruses is actually much much better than even a decade ago
3. We are changing the way vaccines work (some of the new ones are anyway)... instead of "training" our immune systems with "de-activated" virus... we are now directly creating the correct immune response
4.Many companies want to be the first to sell 5 billion doses (or 10 billion if it requires 2 doses to inoculate 1 person).

Besides, even if there are 70 efforts going on around the world, not a single one has entered into peer reviewed wide scale testing yet (China reported they are giving everyone in the military a trial vaccine - 2 million people - but it will likely be months before they know that it is safe and effective).

[milestogo]

11. Thanks for the good information.

[Igel]

31. One more to add.

Some viruses are harder to develop vaccines for than others. HIV's a bear because of the way it hides. Flu's easy, but it's a bear because it mutates out from under immunity quickly. Coronavirus is in the "easy" camp--it doesn't mutate as readily. The question is whether long-term immunity is possible (since with common coronaviruses it isn't), but there are indications pointing in that direction.

[Shermann]

14. Mostly good info

From what I've read, item #4 is a bust. There will be cost pressure to make this available to everybody, and they will be lucky to break even.

5. Massive parallel development. There are over a hundred vaccines in development. Normally this type of crowded market would scare any drug companies away from entering the field. Due to the unprecedented nature of this pandemic, countries and companies are doing the right thing. Many of these are using different approaches, so the probability of at least one safe and effective vaccine looks pretty good.

[Baclava]

12. They already had the SARS genome study but never developed a vaccine, still a long way to go

Small vaccine tests in a lab compared to when any vaccine is ready for use in millions of the general public, still a year away, if it works

[Ms. Toad]

16. Stop swallowing trump hype.

There is not yet an effective vaccine for a single disease caused by a coronavirus.

People are hyping the early stages of development. We don't yet whether it is even possible to develop immunity.

All that has been completed, so far are studies to determine if the proposed vaccine is safe enough to even start testing tho see if it is effective.

Yes, there are lots of companies working on developing vaccines, butt it is inaccurate to suggest they will be ready to go soon.

[uponit7771]

33. "People are hyping the early stages of development." +1, ... and it happens a lot during index

... points in the DOW and S&P

THey've stopped carind about the NASDAQ, just let that bubble wild worse than 2000 !!

[WePurrsevere]

17. I'll believe it when I see it but won't take it until tested properly. nt

[LiberalFighter]

18. Pfizer would be negative about succeeding with their vaccine? Would be bad PR.

[marie999]

19. The way I understand it is the federal government is paying these companies

make the vaccine before its final phase so if it works there will be millions of doses ready. That does not mean that any of these vaccines will work. This is a new approach. Usually, a company would have to do this on its own and it would cost them too much so they wait until they get the okay from the government that their vaccine may be given to people. This is a novel coronavirus.

[Nevilledog]

20. It's easy to develop a vaccine that doesn't work.

[soothsayer]

21. +1000

[uponit7771]

36. +1, exactly what happened in 1918 and one of the reasons there was a "2nd wave" there was

... because they non working vaccine came out.

These people are going to get a lot of people killed

There's no reason for humans to believe this quick turnaround vaccine isn't going to parralize people too like those quick polio vaccines did.

This is going to take some time.

[Bettie]

23. There has never been a successful Coronavirus vaccine

There is unlikely to be one for Covid 19, but big pharma just wants to extract money from the rubes...as always.

I've read several articles about this, but this explains why pretty well. I was directed to it by a friend who spent her adult life working for a pharma company in viral research.

There are several reasons why our upper respiratory tract is a hard area to target a vaccine.

"It's a separate immune system, if you like, which isn't easily accessible by vaccine technology," Professor Frazer told the Health Report.

Despite your upper respiratory tract feeling very much like it's inside your body, it's effectively considered an external surface for the purposes of immunization.

"It's a bit like trying to get a vaccine to kill a virus on the surface of your skin."

[JCMach1]

30. This right here...

Prophylaxis is several time more likely than vaccine

[customerserviceguy]

24. Nobody's thrown trillions of dollars

at the common cold yet. And it took a long time before HIV started to get any decent funding.

[backscatter712]

25. 1. New technology. 2. It's pretty similar to the first SARS virus, which has some research.

The new technology is CRISPR, and RNA sequencing, so instead of the guesswork of trying different ways to attenuate a live virus, or break viruses into bits with some protein pieces still recognizable by human immune systems, now they're using DNA/RNA sequencing to create just certain proteins of the virus.

Also, Captain Trumps is a close-cousin of SARS, so they started with the animal models and techniques they learned trying to develop a SARS vaccine. The biggest problem with the SARS vaccine candidates after I googled was that the candidates they had at the time provoked nasty auto-immune problems in the animals and tissue samples they used. But they learned quite a bit and are putting that knowledge to work.

Of course, developing what looks like a vaccine happens fairly quickly. Figuring out if the vaccine is 1. safe, and 2. actually works is the part that takes a while. That takes loooooooong months of double-blind trials. Maybe if we're lucky, we'll see a trial success and first vaccine production by the middle of next year. That's my guess.

Of course, the pharmcos like Pfizer, and the Trump administration are going to blow sunshine up our asses by telling us the vaccine will be ready any minute. It'll take longer than they say it will.

[ananda]

26. I hope Trump and Jared don't buy it all up.

Like they did Remdesivir.

[GulfCoast66]

27. There was a similar push for one of the earlier SARS viruses

Can’t remember exactly which one.

Anyway, before the vaccine was finished, it became apparent the virus was too deadly to become a pandemic. It burnt itself out. So unwisely funding was stopped. But looked promising. So now they do not have to start from scratch. The data from the earlier attempt was available for everyone.

Plus, our improvements in genetic manipulation has made things much easier.

I think we will get a vaccine. But it won’t be this year.

[meadowlander]

28. They did a lot of work on SARS

but the funding fizzled out when the disease went away due to public health measures like social distancing.

If you throw all the combined resources of the world's medical research industry at a problem, you can come up with a lot of potential solutions relatively quickly.

Whether any of them actually works, only time will tell.

But the larger point (for things like climate change) is that we could solve these kinds of problems if we kept focused and prioritised them.

[JCMach1]

29. Don't believe the hype

We have nothing close to safe and effective yet...

[LisaL]

35. Of all the things to be concerned about.

Why don't you at least wait until they actually develop a vaccine?

[scarletlib]

37. There had already been a lot of R&D on the corona virus before COVID 19.

There was interest in developing a vaccine after the SARS and MERS outbreaks. But those diseases died out and funding for research dried up.