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Yo_Mama_Been_Loggin

(107,705 posts)
Wed Sep 9, 2020, 02:09 PM Sep 2020

Covid-19 vaccine trial participant had serious neurological symptoms, but could be discharged today,

The participant who triggered a global shutdown of AstraZeneca's Phase 3 Covid-19 vaccine trials was a woman in the United Kingdom who experienced neurological symptoms consistent with a rare but serious spinal inflammatory disorder called transverse myelitis, the drug maker's chief executive, Pascal Soriot, said during a private conference call with investors on Wednesday morning.

The woman's diagnosis has not been confirmed yet, but she is improving and will likely be discharged from the hospital as early as today, Soriot said.

The board tasked with overseeing the data and safety components of the AstraZeneca clinical trials confirmed that the participant was injected with the company's Covid-19 vaccine and not a placebo, Soriot said on the conference call, which was set up by the investment bank J.P. Morgan.

Soriot also confirmed that the clinical trial was halted once previously in July after a participant experienced neurological symptoms. Upon further examination, that participant was diagnosed with multiple sclerosis, deemed to be unrelated to the Covid-19 vaccine treatment, he said.

https://www.msn.com/en-us/health/medical/covid-19-vaccine-trial-participant-had-serious-neurological-symptoms-but-could-be-discharged-today-astrazeneca-ceo-says/ar-BB18RRF6?li=BBnba9O&ocid=DELLDHP

Just think what will happen if Trump's Super Duper Warp Speed vaccine gets released.

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LiberalLoner

(9,761 posts)
1. Probably MS.
Wed Sep 9, 2020, 02:20 PM
Sep 2020

That was my first sign I had MS, when I ended up in the ICU with Transverse Myelitis along with some lesions in my brain.

I hope she recovers, as much as possible.

LisaL

(44,967 posts)
5. Well, the first one apparently had multiple sclerosis. They don't know about a second one yet.
Wed Sep 9, 2020, 02:28 PM
Sep 2020

It wouldn't surprise me that people might have pre-existing conditions they don't know about. When they sign up to test the vaccine, the pre-exciting conditions that they don't even know about, might interact badly with the vaccine. It might be this vaccine shouldn't be given to people with MS.

hlthe2b

(102,104 posts)
3. Oh, boy. MS is a diagnosis made after excluding other likely diagnoses. There is no single test nor
Wed Sep 9, 2020, 02:25 PM
Sep 2020

presenting symptom that is unique to MS. That means the rate of misdiagnosis remains around 5%-10%, indicating that 1 in 20 patients thought to have MS has, instead, a condition resembling MS, which can include chronic latent infection with a number of viral and bacterial diseases (e.g., Lyme, Syphilis) in addition to various autoimmune conditions, genetic disorders, metabolic conditions, cancer, and spinal vascular or degenerative disease.

Not saying they are wrong, but I sure wish I could see how they arrived at the conclusion that it was MS, what other diagnoses they ruled out, and how, and exactly why they believe it is not associated in any way with the vaccine. It is possible they were able to identify symptoms that preceded the vaccine and if so that would be supportive of their conclusions.

Still, this is not going to go over well with the medical/scientific community unless more information is provided.

hlthe2b

(102,104 posts)
6. Not always. It is a diagnosis of exclusion. Spinal fluid analysis and MRI are helpful, but
Wed Sep 9, 2020, 02:31 PM
Sep 2020

the findings are not pathognomonic. If the findings are most consistent with MS and there are multiple inconsistencies with other possible etiologies, then MS is concluded to be the diagnosis. In most cases, it is fairly clear cut due to the multiple inconsistencies with other possible diagnoses, but it remains an exclusion diagnosis that concludes the "best fit."

I repeat my assumption that there may have been clinical evidence of symptoms that had manifest BEFORE the vaccine trial. That would be the best reason to conclude no association.

marybourg

(12,584 posts)
7. I read that transverse myelitis is thought to be triggered
Wed Sep 9, 2020, 02:50 PM
Sep 2020

by a virus. This vaccine is based on an adenovirus carrying the fragment into the bloodstream.

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