At least one sell-sider not impressed with AstraZeneca COVID-19 results

[Klaralven]

At least one sell-sider not impressed with AstraZeneca COVID-19 results; AZN slips, while Pfizer, BioNTech, Moderna gain

On just the headline numbers alone, the AstraZeneca (NASDAQ:AZN)/Oxford Covid-19 vaccine trial numbers (on average preventing 70% of infections) didn't match the 90%+ results from the Pfizer/BioNTech (PFE, BNTX) and Moderna (NASDAQ:MRNA) studies.

SVB Leerink's Geoff Porges throws a bit more shade on things, calling AZN's efficacy results "embellished," and raising questions about safety data disclosures. Porges believes the vaccine will never be licensed for U.S. use.

https://seekingalpha.com/news/3638661-least-one-sell-sider-not-impressed-astrazeneca-covidminus-19-results-azn-slips-while-pfizer

AstraZeneca's 70% effectiveness is just not enough, since even after getting the shot, you have a 1 in 3 chance of getting Covid after being exposied. With Moderna and Pfizer/BioNTech you have only a 1 in 10 or 1 in 20 chance of getting sick after exposure.

AstraZeneca's would be OK if it were the only vaccine. Everyone would have to get the shot and herd immunity would suppress Covid levels. However, with too many vaccine holdouts, it just isn't good enough.

[Blue_playwright]

1. I would trust Oxford University...

...researchers over American profit driven companies.

[Klaralven]

9. Oxford used an approach similar to the Russian Sputnik V vaccine

Oxford used an attenuated Chimpanzee adenovirus fused with the coronavirus spike protein.

Oxford used two different human adenoviruses fused with the coronavirus spike protein.

[Native]

2. According to the BBC, link below, it's 90% effective for those given a 1/2 sized 1st dose.

And they are saying they will be able to easily tweak the vaccine to up its efficacy.

https://www.bbc.com/news/health-55040635

[Klaralven]

3. But it is 60% effective for those given two full-sized doses

One dosing regimen (n=2,741) showed vaccine efficacy of 90% when AZD1222 was given as a half dose, followed by a full dose at least one month apart, and another dosing regimen (n=8,895) showed 62% efficacy when given as two full doses at least one month apart.

https://www.astrazeneca.com/media-centre/press-releases/2020/azd1222hlr.html

Note that the 62% effectiveness was from the larger study.

[Native]

7. 2 full doses - 62%, 1/2 dose followed by a full one - 90%, for an overall 70% protection rate.

Two full doses of the Oxford vaccine gave 62% protection, a half dose followed by a full dose was 90% and overall the trial showed 70% protection.

[Statistical]

4. While 70% isn't great given production and distribution bottlenecks

having an additional 50 million people vaccinated at 70% is better than zero especially in the early months (Dec - March) where rapidly rising rates in vaccinated can make a huge difference.

[bluecollar2]

5. 70% based on only 12000 tests is quite effective actually

The other two vaccines were tested on 30 and 40 thousand volunteers according to a report on CNN.

As was mentioned earlier...I trust Oxford more than I trust Wall Street.

[Klaralven]

6. AstraZeneca is one of the larger global pharma companies -- $25 billion annual revenues.

They are AZN on the NASDAQ. https://en.wikipedia.org/wiki/AstraZeneca

Zeneca goes back to a spinout of Imperial Chemical Industries. Since then the City of London financial wizards have cobbled together the modern AZN through various mergers and acquisitions.

[Klaralven]

8. Astra Delivers But Can't Match Rivals. Here's What We Know

The pressure was on AstraZeneca Plc and the University of Oxford after stunning Covid-19 vaccine trial results from Pfizer Inc. and Moderna Inc., and the U.K. partners delivered, even if they couldn’t match the data from the two front-runners.

Scientists will now closely scrutinize the preliminary results. The report is significant because Astra and Oxford are taking a different approach from the one used by Pfizer and Moderna, and vaccine advocates say multiple shots will be needed to stop a contagion that’s killed almost 1.4 million people. Here’s what we know, and what the results could mean in the battle.

How do the results compare with the Pfizer and Moderna data?

The Astra-Oxford vaccine on average prevented 70% of cases in large trials in the U.K. and Brazil. The results combined data from two different dosing regimens, which may leave questions open about the best way to give the shot. One regimen showed efficacy of 90%, while another yielded 62% efficacy. The numbers together couldn’t meet the high bar set by Pfizer and partner BioNTech SE, which unveiled findings showing their shot was 95% effective. Results from Moderna suggested its vaccine was equally strong.

https://www.bloomberg.com/news/articles/2020-11-23/astra-delivers-but-can-t-match-rivals-here-s-what-we-know

[llashram]

10. "warp speed" bullshit

is going to murder more Americans for political points for chump. I thought it takes years to perfect safe drugs ingested by human beings? Couldn't find much on internet searches.