Breakthrough drug might cure COVID-19 in just five days

[iluvtennis]

https://www.msn.com/en-us/health/medical/breakthrough-drug-might-cure-covid-in-just-five-days/ar-BB1ds8Rk

* Researchers from Tel Aviv’s Ichilov Medical Center developed a coronavirus therapy that was found to cure COVID-19 in 3-5 days in most volunteers who received the drug.

* EXO-CD24 is a medication delivered directly to the lungs, where it’ll help prevent the immune system dealing with COVID-19 from overreacting and causing complications.

* The drug is administered once a day for five minutes via inhalation. In Phase 1 trials, 29 out of 30 people suffering from moderate to severe COVID-19 recovered within 3-5 days, and all of them survived.

It’s too early to call it a miracle cure, but if the conclusions from a recent Phase 1 trial for a new drug called EXO-C24 are backed up in subsequent trials, we might have the first true breakthrough therapy for COVID-19.

That’s in addition to coronavirus vaccines, of course, which will help prevent severe COVID-19 cases and deaths, and even reduce the spread of the illness. But while vaccines can give the immune system a heads-up to the threat it might have to deal with — the real virus — they have a few limitations. First of all, they don’t work on infected people. Secondly, vaccine supply is still limited and vaccinations aren’t available to anybody who might want one. Then there’s the threat of coronavirus mutations that might reduce vaccines’ effect on the virus and extend the pandemic.

But if EXO-C24 can indeed help most coronavirus patients recover within five days, then the drug would not just save more lives. It would also complement vaccines and help address mutations. The drug is meant to calm the immune response that can be deadly in COVID-19 — the so-called cytokine storms — and should have the same effect regardless of how SARS-CoV-2 evolves.

...short article, no more at link

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Wow. Let's keep our eyes on the trials to see if this drug can be another tool in the kit to fight CV-19.

[Celerity]

1. fingers crossed indeed!!!!

[iluvtennis]

3. YASS! nt

[applegrove]

2. Thanks. Afraid to get my hopes up but will cross my fingers.

[iluvtennis]

4. Mine crossed with yours. nt

[electric_blue68]

5. Hope... 🤞🤞🤞🤞🤞🤞🤞🤞🤞🤞🤞🤞🤞🤞

[SheltieLover]

6. K&R!

[roamer65]

7. We still need to get everyone vaccinated, but for those who still catch the virus after it...👍👍.

[iluvtennis]

9. Yes...we still need the vaccines. nt

[Cicada]

8. More good news!

[Leghorn21]

10. 29 out of 30 people recovered??

COUNT ME IN!

All best wishes, researchers!!

[SunSeeker]

14. That's a really small sample. Plus, 29 out of 30 is a 97% recovery rate...what it already is.

The real difference is that none of the 30 died. And the 29 who recovered did so within 5 days, which is huge.

[R Merm]

38. Other articles reported that it was 29 out of 30 severe and critical hospital patients

[jxla]

11. More info from source articles

https://bgr.com/2021/02/06/coronavirus-cure-exo-cd24-trial-israel/
The problem with COVID-19 recovery is that the immune system can develop an exacerbated reaction in at-risk groups, leading to multiple organ failure and death. The phenomenon is called a cytokine storm, and it’s usually deadly.

The hospital conducting the Phase 1 trial described the success as a “huge breakthrough,” according to Time of Israel.

EXO-C24 isn’t an anti-viral that goes after the virus, looking to eliminate it. The immune system can do that on its own, and that’s why many people recover from COVID-19 even without treatment. This drug deals with the cytokine storm, preventing the overreaction from taking place.


https://www.timesofisrael.com/new-israeli-drug-cured-moderate-to-serious-covid-cases-within-days-hospital/
It uses exosomes — tiny carrier sacs that shuttle materials between cells — to deliver a protein called CD24 to the lungs, which Arber has spent decades researching.

“This protein is located on the surface of cells and has a well known and important role in regulating the immune system,” said researcher Shiran Shapira of Arber’s lab.

The protein helps calm down the immune system and curb the storm.

“The preparation is inhaled once a day for a few minutes, for five days,” Arber said. “The preparation is directed straight to the heart of the storm — the lungs — so unlike other formulas… which selectively restrain a certain cytokine, or operate widely but cause many serious side effects, EXO-CD24 is administered locally, works broadly and without side effects.”

[iluvtennis]

20. thank you for posting the additional sources. nt

[mjvpi]

23. If my memory serves, that over reaction is what made the 1918 virus so bad.

Healthy and the young were the most vulnerable during that one. This sounds like it might be a new way to deal with a problem outside of Covid. I’m so glad that there are legions smarter than me.

[onecaliberal]

12. This sounds really promising. Let's hope the trials pan out.

[sandensea]

13. The Jewish COVID laser!

Margie's head exploding in 5,4,3...

[Nitram]

15. I hope this is for real. It would save a lot of lives and free up the economy.

[SCantiGOP]

16. Good to hear, but 29 of 30?

If it were 30,000, I would be celebrating the end of the Dark Times.

[BobTheSubgenius]

17. This is VERY hopeful, but I am not that surprised.

Any country that has lasers in orbit ought to find that creating cures for serious medical conditions is a day at the beach.

[Bayard]

18. This could be wonderful news!

But they will have to find a catchier name than EXO-C24.

[NJCher]

24. How about

Exo-dus.

Works on a few different levels.

[Johnny999r]

41. EXOUT COVID

EXOUT COVID, or EX OUT COVID. A play on EXO PLANETS, other worlds in the Milky Way Galaxy.

[Aussie105]

19. It's got to be better than

injecting bleach, or shoving a UV light up your (BEEP)!
Or that other stuff some bigly brained genius kept touting.

If it works . . .
Another weapon in the armory against COVID!

[Vivienne235729]

21. Wow!! Keeping my fingers crossed.

[OnlinePoker]

22. Was it made from Trump's "miracle" blood? n/t

[colsohlibgal]

25. Very Encouraging

This could be a game changer along with mass vaccination.

Can’t wait to get back to something approaching normal.

Trump has so much blood on his hands.....just wonder where we’d be now if we had had a competent President in office rather than that Orange Jerk.

[Ferrets are Cool]

26. Isn't it wonderful to have these things called "scientists"?

[Blue Owl]

27. Hey Pillow Guy, the mark of the beast just called

He wants to give your vaccine back

[LaMouffette]

28. Wonderful news! Thank you for posting! The treatment aspect of Covid is something Rachel

Maddow keeps in the foreground, obviously because of her experience with Susan getting Covid.

Here's part of the transcript of her interview with Dr. Fauci on January 4, 2021:

But the real goal, Rachel, is to do what we did so successfully with HIV. To get direct, acting antiviral drugs so that when someone comes in with symptoms to prevent them from going in the hospital, you might give them a seven to ten-day course. Unlike HIV, which requires a lifetime of course, but the same type of drug, one that`s a very powerful drug, directly acting on the virus itself.

That`s something that we`re putting a lot of effort in, and when we get that, that will really turn around the entire situation of our ability to prevent someone from progressing and going into a state where they really have advanced disease.

MADDOW: And that`s the sort of theory of the case for the best shot for therapeutics. But is there anything that looks promising along those lines already? Or is this something that`s years away in terms of development?

FAUCI: No. Well, you know, normally under business as usual-type things, it might have been years away. But there are a number of companies that have candidates that they`re looking at, that might look pretty, you know, the companies are a little shy telling you about things, but being at the NIH where we fund scientists who are doing this, I think it`s going to be much sooner than we think.

That once you get something that looks like it`s a hit, as we call it, namely, something that really does act. You get it into a phase one trial quickly and because the situation is so dire in the sense of the need for therapeutics, you move it along. You don`t just want to forget about safety. Safety is always important. But if you can show it`s safe, has good antiviral activity, we can move relatively quickly on that.

And as I mentioned, there are a couple of candidates that are looking promising in the test tube, and then from there you go to an animal model and then get it into humans.

I bet she will have Dr. Fauci back on to discuss this latest development.

[MustLoveBeagles]

29. Fingers and toes crossed

[pnwmom]

30. I sure hope so, but this is only a Phase 1 trial. Many drugs don't make it past

Phase 2. (There are three phases.)

[Meowmee]

31. Lets hope it continues to help people

[Tom Rinaldo]

32. This is exciting. If ithis pans out I hope it is easy and inexpensive to mass produce

otherwise only a small fraction of those who could be helped by this treatment will be able to receive it.

[HUAJIAO]

33. Ivermectin has been doing the same thing for several months now.

It protects the user from getting symptoms, other than perhaps mild ones, if he/she gets covid, and if given to someone already with symptoms, it greatly reduces, gets rid of symptoms in just a few days.



Front Line Covid19 Critical Care Alliance
https://covid19criticalcare.com/

Presser in December – great video

&t=2s

Congressional hearing also another great video

[Mike Nelson]

34. This would be...

... so great. First Biden/Harris, then this... keep the good news happening!

[paleotn]

35. Great news, but terrible article title.

Any help with one of the worst Covid-19 complications is a godsend. That's great news. But, it's a treatment for a Covid-19 complication, not a cure for Covid-19. You prevent people from contracting viral disease through vaccinations. You can tamp down the impact of viral infection. You can treat complications caused by viral infection. But you cannot cure viral infection Not with present technology.

[keithbvadu2]

36. But is it as effective as hydroxychloroquine with a Lysol/bleach chaser?

But is it as effective as hydroxychloroquine with a Lysol/bleach chaser?

[kirkuchiyo]

37. Interesting if true

I'll wait to see it published in a peer reviewed medical journal before jumping for joy.

[Poiuyt]

39. This is good news indeed

Let's hope it pans out

[usajumpedtheshark]

40. Umm, sure would be surprising that an experimental drug being developed to treat ovarian cancer

could "cure" a viral condition through an anti inflammatory effect.We already have meds that treat cytokine storms and not everyone afflicted by covid 19 suffer from these storms. As a cynic, I have to wonder how much of this is hype promoting the country as the hospital chief even mentions how great it would to bring a white and blue cure to the world. I would be just as cynical if some American doctor talked about bringing a red white and blue cure to the world. I hope that Phase II trials with double blind studies confirm their earlier results.