AstraZeneca: German researchers discover thrombosis trigger

[Klaralven]

Researchers at the Greifswald teaching hospital in northern Germany said on Friday that they had discovered the cause of the unusual blood clot problems found in some recipients of the AstraZeneca coronavirus vaccine, public broadcaster Norddeutscher Rundfunk (NDR) reported.

The investigation showed how the vaccine caused blood clots in the brain in a few patients. The discovery means that targeted treatment can be developed to prevent problems.

The success was a result of cooperation between the Greifswald hospital, state health regulator the Paul Ehrlich Institute (PEI), as well as doctors from Austria — a nurse there died from thrombosis in the brain after being vaccinated with the AstraZeneca jab.

The researchers emphasized that treatment would only be possible in patients where blood clots appear, rather than as a preventative treatment.

https://www.dw.com/en/astrazeneca-german-researchers-discover-thrombosis-trigger/a-56925550

[mucifer]

1. Not good news. Yesterday they said it was a coincidence

[soothsayer]

6. Exactly, I just heard that "coincidence" on bbc news this morning

[Hortensis]

16. This IS good news. It's about discovering cures to problems,

not about ignoring what this is all about to focus on something that won't matter squat to the billions who need protection from this virus.

[Roland99]

2. Not a Dr. how does one know that one has a blood clot?

[Klaralven]

4. The same symptoms as a stroke, which is also a result of blood clots in the brain

[Roland99]

14. Thanks

[ananda]

3. Too bad. Turns out I was way wrong about that one.

I got the Moderna vaccine yesterday... just a sore arm
but not nearly as sore as it was when I took the
Shingrix vaccine several years ago.

[mucifer]

5. Same for me Pfizer gave me only a sore arm and mild fatigue. The shingles vaccine

kicked my ass with fevers and aching the day after each shot.

But, a close relative had a temporary gastric feeding tube because his shingles was so bad it attacked his vocal cords. So achy fevers was nothing compared to what he went through for months.

[sdfernando]

15. I'm getting my Shingrix this weekend and I'm looking forward to it.

Had a friend that had a bad case and he had shingles sores in his eyelids. Probably the worst place in the world, excruciating pain every time he blinked and got very little sleep because REM eye movements would wake him up again in pain. I don't want to experience that at all...and I may be susceptible because I had the Chicken Pox TWICE as a child.

[lagomorph777]

7. The article is only a tease. It fails to state what they actually found.

I hate it when they cop out like that.

[Shanti Shanti Shanti]

8. There's an inside link, 7 cases per 1.6 M, Contraception pill causes same, 1100 per M, no uproar

[Jirel]

9. Thank you for saying this.

The response is so disproportionate.

[Hugin]

13. +1 n/t

[muriel_volestrangler]

20. You may need to understand medical German to find out

It links to a German report: https://translate.google.com/translate?hl=en&sl=de&u=https://www.ndr.de/nachrichten/mecklenburg-vorpommern/AstraZeneca-Greifswalder-Forscher-haben-offenbar-Thrombose-Ursache-gefunden-,coronavirus4660.html&prev=search&pto=aue

in which the only detail translates (Google) as

When examining the samples, the researchers found that the vaccine activates the blood platelets, or thrombocytes. This normally only happens in the body when a wound is healing, when the blood coagulates and the wound closes. In some patients, the vaccination activates a mechanism that causes blood clots to form in the brain. Because the mechanism was so clearly identified, a targeted treatment option could also be developed. Those affected can now be given an active ingredient that helps against the thrombosis.

The university's page on it isn't much better:

The antibody, which in rare cases is formed after vaccination, activates the blood platelets. These then act like wound healing and trigger thrombosis in the brain.

https://translate.google.com/translate?hl=en&sl=de&u=https://www.medizin.uni-greifswald.de/de/ueber-die-umg/aktuelles/astrazeneca-impfung/&prev=search&pto=aue

There's a press conference you can download, but it's in German.

[lagomorph777]

21. Wow, you went the extra mile!

Thank you for that!

[uponit7771]

10. Just damn, this doesn't help

[The King of Prussia]

11. Just had the AstraZeneca

I am completely unbothered by this.

[Hugin]

12. I'm wondering if the problem isn't in the carrier rather than the...

portion of the vaccine which causes the immune response.

Since there are several other vaccines similar in how they are composed, which don't seem to have this issue.

The article is not very specific on the problem.

[BobTheSubgenius]

17. I don't know how I feel about this.

The clotting potential, not this latest research, although that is also kinda muddy, ATM.

My paternal forebears are, or were, rife with strokes, which indicates a potential problem for me, as I see it. Doctors have been pretty mealy-mouthed about it, and while it's an inaccurate comparison, an apparent opposite is hemophilia, which is definitely genetic.

On the other hand, when Staph A ravaged two heart valves to the point of needing replacement, one is titanium, which has the advantage of lasting several lifetimes, but the disadvantage of forming clots at a hell of a rate. Consequently, I take anti-coagulents every day (7mg of warfarin daily, if you're curious), and I don't know how that would factor into this particular paradigm.

So, in short. Am I more at risk because of genetics, or less, because of a coincidental treatment regime?

[blue neen]

19. There are genetic reasons for blood clots.

One is called Leiden Factor V. It's in about 5% of the population here, but higher in places like Sweden, where it's 15%.