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Related: Editorials & Other Articles, Issue Forums, Alliance Forums, Region ForumsStanford Scientists Post mRNA Sequence for Moderna Vaccine on Github
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the least great american whale
@Boringstein
this rules and is nothing short of heroic
Stanford Scientists Post mRNA Sequence for Moderna Vaccine on Github
A group of Stanford researchers has hacked Modernas messenger RNA (mRNA) vaccine for the novel coronavirus, Motherboard first reported on Monday, and published its entire genetic sequence on the...
gizmodo.com
5:39 PM · Mar 29, 2021
the least great american whale
@Boringstein
this rules and is nothing short of heroic
Stanford Scientists Post mRNA Sequence for Moderna Vaccine on Github
A group of Stanford researchers has hacked Modernas messenger RNA (mRNA) vaccine for the novel coronavirus, Motherboard first reported on Monday, and published its entire genetic sequence on the...
gizmodo.com
5:39 PM · Mar 29, 2021
https://gizmodo.com/stanford-scientists-post-entire-mrna-sequence-for-moder-1846576268
A group of Stanford researchers has hacked Modernas messenger RNA (mRNA) vaccine for the novel coronavirus, Motherboard first reported on Monday, and published its entire genetic sequence on the open-source code repository Github.
The mRNA vaccines work by delivering genetic information that allows the bodys own cells to produce a viral proteinsuch as a harmless, engineered version of the spike protein that the coronavirus uses to break its way into the bodys cells. When the body subsequently produces that protein, the immune system rapidly mobilizes to fight it, conducting a sort of live-fire training exercise that prepares it to fight the actual coronavirus; the actual mRNA delivered by the vaccine quickly disintegrates, but the antibodies stick around as a garrison against future infection. Per the MIT News Office, this allows for much easier and faster production than prior generations of vaccines relying on manufacturing the proteins under laboratory conditions. The mRNA sequence more or less serves as a sort of source code for the vaccine.
The documents the Stanford team published on Github include two pages of explanation and two pages containing the entire mRNA sequence for Modernas vaccine. Researchers wrote in the report that although Modernas mRNA has ended up in a large swathe of the population, scientists and medical personnel dont have access to the actual genetic sequences involved.
With the rollout of vaccines for COVID-19, these synthetic mRNAs have become broadly distributed RNA species in numerous human populations, the researchers wrote. Despite their ubiquity, sequences are not always available for such RNAs... Sharing of sequence information for broadly used therapeutics has the benefit of allowing any researchers or clinicians using sequencing approaches to rapidly identify such sequences as therapeutic-derived rather than host or infectious in origin.
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Stanford Scientists Post mRNA Sequence for Moderna Vaccine on Github (Original Post)
Nevilledog
Mar 2021
OP
I suspect the patent applies mostly to the lipid nano particle delivery system.
roamer65
Mar 2021
#1
Interesting article. Further paragraphs address how the sequences were obtained,
crickets
Mar 2021
#4
roamer65
(36,745 posts)1. I suspect the patent applies mostly to the lipid nano particle delivery system.
That is the amazing part of their vaccine.
Most of the mRNA would just be the spike protein sequence from SARS-CoV-2.
LisaL
(44,972 posts)2. Now we can all make it in our basements.
Oh wait...
dsc
(52,155 posts)3. we can print it on a 3D printer
winstars
(4,219 posts)6. I can't, thats where I keep my email server!!!! LOL
crickets
(25,959 posts)4. Interesting article. Further paragraphs address how the sequences were obtained,
that scientists had permission from the FDA, and that Moderna was notified and did not object. Pfizer's mRNA sequence has been available for some time. Neat. Thanks, Nevilledog.
dalton99a
(81,426 posts)5. So they found the code for the microchip