J&J fix may be as simple as aspiration

[DenaliDemocrat]

https://ashpublications.org/blood/article/109/7/2832/125650/Adenovirus-induced-thrombocytopenia-the-role-of


Fix may be aspiration to ensure intra muscular injection.

[Ms. Toad]

1. Interesting -

Note the date on the article. I suggested in an earlier post that the same problem might be associated with other vaccines using an adenovirus vector.

That said, on a quick read I don't see any of the characteristics cited for either J&J or AstraZeneca (cerebral venous sinus thrombosis, splanchnic vein thrombosis, low levels of platelets, aggravated by heparin, PF4 antibodies)

[DenaliDemocrat]

2. No, but clearly notes platelet activation

Mode of action most suspected right now is DNA fragment particles forming weak ionic bond with platelets then immune response to foreign DNA thus binding the platelets.

[Ms. Toad]

3. It's hard to sort out -

but it sounds like an abnormally high platelet concentration, rather than low. But I haven't had time to read it in detail.

[roamer65]

4. We are damn lucky to have Pfizer and Moderna's lipid nanoparticle system.

Near perfect delivery of the mRNA without major side effects.

The possibilities for cancer immunotherapy are endless.