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Related: Editorials & Other Articles, Issue Forums, Alliance Forums, Region ForumsA new study dealing with mushrooms and depression
Psilocybin, a drug derived from magic mushrooms, appears to be at least as effective as the antidepressant escitalopram, when administered in a therapeutic setting.
Psilocybin, a psychedelic drug derived from magic mushrooms, may be at least as effective as one of the leading antidepressants at treating depression, a study has found. The research provides further evidence in favour of licensing the therapy as a mental health treatment.
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Previous research has shown that psilocybin has promise in alleviating treatment-resistant depression. In 2016, a team based at NYU Grossman School of Medicine published a study showing that cancer patients reported immediate, substantial, and sustained improvements in anxiety and depression following treatment with psilocybin combined with psychotherapy sessions. Then, in 2020, the same team followed up with the patients and found that 70 per cent had experienced long-term positive life changes following the therapy.
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However, the team also looked at two additional measures: response and remission. Response is defined as when a persons depression score reduces by at least 50 per cent; 70 per cent of people in the psilocybin group met this requirement, whereas only 48 per cent of the people in the antidepressant group did.
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These findings provide further support for the growing evidence base that shows that in people with depression, psilocybin offers an alternative treatment to traditional antidepressants, said Professor David Nutt, principal investigator on the study.
In our study, psilocybin worked faster than escitalopram and was well tolerated, with a very different adverse effects profile. We look forward to further trials, which if positive should lead to psilocybin becoming a licensed medicine.
More: https://www.sciencefocus.com/news/new-study-bolsters-support-for-magic-mushroom-treatment-for-depression/
2. https://www.nejm.org/doi/10.1056/NEJMoa2032994
world wide wally
(21,742 posts)dianaredwing
(406 posts)Wonder if all the crap they're feeding cows these days has damaged the mushrooms?
MagickMuffin
(15,937 posts)https://maps.org
Mission
Founded in 1986, the Multidisciplinary Association for Psychedelic Studies (MAPS) is a 501(c)(3) non-profit research and educational organization that develops medical, legal, and cultural contexts for people to benefit from the careful uses of psychedelics and marijuana.
Our Work
We further our mission by:
Developing psychedelics and marijuana into prescription medicines
Training therapists and working to establish a network of treatment centers
Supporting scientific research into spirituality, creativity, and neuroscience
Educating the public honestly about the risks and benefits of psychedelics and marijuana.
hamsterjill
(15,220 posts)Richard D
(8,754 posts). . . mushrooms are near instant relief.
. . . do not require daily dosing
. . . no post SSRI crash and in some cases severe withdrawal
. . . are not patented
. . . increase appreciation for art and music
. . . may increase creativity
. . . Can be incredibly fun
Tommymac
(7,263 posts)THEN I got high.
I'm sure that modern medical research has gone beyond the chew and spew method.
DallasNE
(7,403 posts)It could be that it is too short term to be considered effective. But current treatments just aren't adequate.
Tommymac
(7,263 posts)And it really really helps.
I'll take a puff or two from a vape prn for immediate relief from an anxiety attack.
My psychiatrist approves and has allowed me to substitute these for pills that may do the same thing but give me very bad side affects at times. (I'm in a state that has legalized THC for medical use. Anxiety is one ofthe specified conditions to treat.)
No adverse side affects from the THC.
DallasNE
(7,403 posts)But we are not in a State where THC is legal. About 3-4 puffs of weed addresses the anxiety nicely but it wears off rapidly so a different form of delivery is needed. But these kinds of treatments run square into politics and ignore science and that is the problem. Pills also wear off in pretty short order so you don't do them at the same time for better coverage.
Tommymac
(7,263 posts)The tincture causes THC to build up in my body. Definitely not an efficient way to get high - this is designed for medicinal usage.
I love it because I buy a blend with CBD and THC - long term dosage with the CBD has actually relieved me of a lot of pain I had with rheumatoid/ pre-arthritic shoulders and joints. I have full range of shoulder motion back after years of limited, painful movement in my shoulders. I'd call it a miracle - but in reality it is simply Science getting 'in touch' with Natural remedies.
littlemissmartypants
(22,655 posts)Between Lexapro and mushrooms. Lexapro doesn't help plenty of people...we needed a study for this? Of course, the mushrooms came out on top.
abqtommy
(14,118 posts)process is the presence of a support team to guide the patient successfully through the
process.
rickyhall
(4,889 posts)However, I never did them alone, not with trained professionals, but with experienced guides. Of course, that was forty-five to fifty years ago. I've been on lots of anti-depressants and they were complete wastes of time. I finally conquered depression on my own. I still have occasional bouts but they don't last long.
certainot
(9,090 posts)circumstance and had to go out in public and walk downtown. i did alright but a very unusual hatching of mayflies or some other insect filled the outdoor mall i had to walk through. it was real.
hotdamn00
(38 posts)A lot of people use microdosing of LSD to deal with depression. It's very promising, but still stigmatized:
https://medicalxpress.com/news/2020-02-magic-mushrooms-lsd-depression-anxiety.html