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Related: Editorials & Other Articles, Issue Forums, Alliance Forums, Region ForumsBreakthrough as highly effective malaria vaccine raises hopes of controlling disease
https://www.cnn.com/2021/04/23/uk/malaria-vaccine-oxford-intl-gbr/index.htmlA vaccine against malaria has shown record efficacy in a Phase II trial, a pre-print study released on Friday by Oxford University shows, raising hopes that one of the world's most deadly diseases could be brought under control.
The vaccine, developed by Oxford and known as R21, showed up to 77% efficacy in a trial of 450 children in Burkina Faso over 12 months, the university said in a statement. It said the shot was the first to meet the World Health Organization's Malaria Vaccine Technology Roadmap goal of a malaria vaccine with at least 75% efficacy.
"These are very exciting results showing unprecedented efficacy levels from a vaccine that has been well tolerated in our trial programme," Halidou Tinto, the trial's principal investigator, said in a statement. "We look forward to the upcoming Phase III trial to demonstrate large-scale safety and efficacy data for a vaccine that is greatly needed in this region."
The study inoculated 450 children between the ages of 5 to 17 months. They were split into three groups, and researchers reported the higher dose group were 77% less likely to get the disease, "and 71% in the lower dose adjuvant group, over 12 months of follow-up," the statement said.
The vaccine, developed by Oxford and known as R21, showed up to 77% efficacy in a trial of 450 children in Burkina Faso over 12 months, the university said in a statement. It said the shot was the first to meet the World Health Organization's Malaria Vaccine Technology Roadmap goal of a malaria vaccine with at least 75% efficacy.
"These are very exciting results showing unprecedented efficacy levels from a vaccine that has been well tolerated in our trial programme," Halidou Tinto, the trial's principal investigator, said in a statement. "We look forward to the upcoming Phase III trial to demonstrate large-scale safety and efficacy data for a vaccine that is greatly needed in this region."
The study inoculated 450 children between the ages of 5 to 17 months. They were split into three groups, and researchers reported the higher dose group were 77% less likely to get the disease, "and 71% in the lower dose adjuvant group, over 12 months of follow-up," the statement said.
It is impossible to overstate the importance of this breakthrough.
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Breakthrough as highly effective malaria vaccine raises hopes of controlling disease (Original Post)
WhiskeyGrinder
Apr 2021
OP
It has been achieved in some protozoal diseases in animals, apparently
muriel_volestrangler
Apr 2021
#5
Celerity
(43,349 posts)1. this is a big fucking deal!!!
Lochloosa
(16,064 posts)2. Yes it is.
spinbaby
(15,090 posts)3. I'm surprised this is possible
Malaria is caused by protozoa rather than bacteria or viruses, making it a unique challenge.
Act_of_Reparation
(9,116 posts)4. There have been some serious advances in immunology as of late.
Just going over the literature, it looks like the vaccines target the organisms at specific points in the life cycle, interrupting growth and reproduction. Pretty wild stuff.
muriel_volestrangler
(101,312 posts)5. It has been achieved in some protozoal diseases in animals, apparently