Are there any traditional (attenuated) COVID vaccines in the works? What is their status?

[democrattotheend]

I ask because several of my vaccine-hesitant relatives say they would take a COVID shot that works like a traditional vaccine, with a live, dead or attenuated virus. I believe them because they are not anti-vaxxers in general and had no problem with checking if their immunizations for things like MMR and TDAP were up to date before my son was born.

I found an article about one such candidate, a nasal vaccine that is currently in trials. But it seems like this is years away from becoming a reality. There's a vaccine with EUA in India, Covaxin, that seems to be a more traditional vaccine, but with my limited scientific knowledge I am not sure. My understanding is that Covaxin was denied an EUA and told to apply for full approval because there were enough vaccines already with EUA. If Covaxin is a more traditional vaccine, I think that is a big mistake on the part of the FDA, because at least some people would take the COVID shot if a more traditional vaccine were available.

Does anyone know if any other attenuated COVID vaccines are in the works or available in other parts of the world?

[dalton99a]

1. Codagenix

[democrattotheend]

2. Oh yeah, I think I saw that one

Do you know anything about whether/when it might be approved for use in the US?

[hlthe2b]

3. Codagenix (an intranasal route attenuated vaccine) is very promising BUT it is a fully bioengineered

live virus vaccine--not a chemically treated (attenuated) SARS-COV2 virus. While I am very bullish on it coming to fruition sometime in the next year(s), I'd be really surprised to see the vaccine-hesitant, who have "issues" with mRNA vaccines embracing this technology. It is a very intriguing software-driven biologic approach, but I'd suspect it will engender a LOT of confusion and conspiracy theories.

[WHITT]

4. AstraZeneca

has a hybrid of the old dead-virus vaccine, but because we have a long licensing process, it was already green-lighted by the British system, and only requires normal refrigerated storage, the administration donated our inventory of the AstraZeneca to other countries.

[Merlot]

5. I thought J&J was also made this way and requires only normal

refrigeration. But no one talks about J&J any more. Why isn't J&J suggested as a vax for those who don't like mRNA vax?

[democrattotheend]

7. I asked them about that

But from what I understand, the J&J vaccine is not a traditional vaccine either. It uses an adenovirus, which is a well tested mechanism, but apparently something about it is still experimental - something about a nucleaic vector, I think. Like I said, my knowledge of this is limited. The family members who don't want to get the currently available vaccines actually know a lot more about science and virology than I do, which makes it harder to argue with them about it.

[hlthe2b]

8. AstraZeneca & J&J use adenovirus-vetored vaccine within which a portion of COVID spike protein

DNA (antigen) has been inserted. The adenovirus is a common cold virus rendered harmless, so yes it is a hybrid method.

[Ocelot II]

6. A traditional vaccine would actually be less safe than the mRNA vaccines

because traditional vaccines use killed or weakened viruses; in other words, the virus' DNA is injected into you, which forces your body to develop an immune response. mRNA vaccines, however, don't use any viral DNA at all. They are the product of years of research on CRISPR sequences, which can be spliced into a cell's messenger RNA, which creates various proteins. The mRNA vaccines specifically target the spikes on the virus that it uses to invade cells with, so your body recognizes the proteins that make those spikes and develops immune responses to just that material. No viral DNA, which could make more viruses, is used.

[muriel_volestrangler]

9. Sinovac and Sinopharm, but I doubt they're going to apply for US clearance

https://www.bbc.co.uk/news/world-asia-china-57817591