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Wed Sep 22, 2021, 11:02 AM

A new COVID-19 booster shot that could protect against multiple variants is being tested in humans

A COVID-19 booster shot that may protect against multiple variants is being tested in humans.

It uses new vaccine technology that self-replicates once injected in the muscle.

The vaccine may need a lower dose than existing shots, potentially reducing side effects.

https://www.businessinsider.com/covid-booster-vaccine-side-effects-multiple-variants-gritstone-trial-2021-9

This looks promising.

4 replies, 613 views

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Reply A new COVID-19 booster shot that could protect against multiple variants is being tested in humans (Original post)
Lasher Sep 22 OP
SheltieLover Sep 22 #1
gojoe12 Sep 22 #2
Mme. Defarge Sep 22 #3
Red Pest Sep 22 #4

Response to Lasher (Original post)

Wed Sep 22, 2021, 11:04 AM

1. K&R!

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Response to Lasher (Original post)

Wed Sep 22, 2021, 11:04 AM

2. Thank you!

Iíve been hoping for something like this!

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Response to Lasher (Original post)

Wed Sep 22, 2021, 12:04 PM

3. God willing

and the creek donít rise.

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Response to Lasher (Original post)

Wed Sep 22, 2021, 01:58 PM

4. Very preliminary testing in a small cohort of humans

This will take some time and lots of data to get the self-amplifying mRNA into general use. My reading about the technology [link:https://www.nature.com/articles/s41434-020-00204-y#Fig1|] suggests that it is a safe and logical extension of the current mRNA vaccines, but again lots of data to confirm this will be necessary. In general, since mRNA vaccines (conventional) do not enter the nucleus of cells, they are much safer than DNA vaccines (which are pretty safe, too). The self-amplifying mRNA vaccine candidates and the trans-amplifying mRNA vaccine candidates should be just as safe as conventional mRNA vaccines and have the advantage of lower doses being necessary.

We shall see how it all works out.

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