Are COVID-19 Nasal Spray Vaccines Coming Soon?

[StarryNite]

Are COVID-19 Nasal Spray Vaccines Coming Soon?
Alyssa Billingsley, PharmD, is a pharmacist on the GoodRx team with a decade of experience in pharmacy. She’s also adjunct faculty at St. Louis College of Pharmacy.
October 18, 2021, 3:40PM (PT)

Excerpt:

When will a COVID-19 nasal spray vaccine be available?
Many of the COVID-19 nasal spray vaccines are in phase 1 clinical trials. This means that they’re being studied in a small group of people. The purpose of these trials is to look at safety and figure out dosing. But some of these vaccines may not make it to phase 2 or 3 trials.

There are a few vaccines that are further along, but many of them are just getting started with larger trials. Because of this, we may not see a nasal spray vaccine until at least 2022 — assuming it works well in humans.

The bottom line
Nasal spray vaccines have several potential advantages over injectable vaccines. There are several nasal spray vaccines in the pipeline, but research on most is just getting started. And we don’t know yet how well they’ll stack up against authorized or approved injectable COVID-19 vaccines.

But if they provide long-lasting protection and help curb viral spread, they could be a useful tool in the fight against COVID-19.



[link:https://www.goodrx.com/blog/covid-19-nasal-spray/|

[MineralMan]

1. Just tell folks in some places that it's a new form of meth,

and they'll sniff it right up.

[AZProgressive]

3. There actually is a nasal inhaler form of meth

But it is a different isomer than the street drug.

Levomethamphetamine[note 1] is the levorotatory (L-enantiomer) form of methamphetamine. Levomethamphetamine is a sympathomimetic vasoconstrictor which is the active ingredient in some over-the-counter (OTC) nasal decongestant inhalers in the United States.[note 2]

https://en.m.wikipedia.org/wiki/Levomethamphetamine

[LisaL]

2. I wouldn't count on it.

It's hard to achieve high efficacy with nasal spray vaccines (at least so far).

[democrattotheend]

4. I'm very excited for the Codagenix one

My holdout family members would be much more likely to take that, because it's more like a traditional vaccine, and from what has been explained to me, there are some advantages to targeting the whole virus instead of just the surface spike protein in terms of avoiding selective pressure on the virus. I keep checking to see if/when there will be a clinical trial open for Codagenix. Some of the other ones seem promising too.

Note: my knowledge of virology and science in general is pretty limited here, so I may have gotten some of the details wrong. The family members I have who are against the current vaccines actually know a lot more about biology and virology than I do, which has made it hard to argue with them, even though I'm pretty sure they are fixating on hypothetical risks of the vaccines while downplaying the very real risk of the virus.

[LisaL]

5. It's much more likely those family members will get infected

before these vaccines become available (if ever).
It's has been very difficult to create an efficient nasal spray vaccine.

[StarryNite]

8. The nasal vaccine could lower viral shedding...

It looks promising. I really hope it works out.


From the article:

"nasal vaccines also build up antibodies in your nasal tissue. This might help protect your upper respiratory tract, which is the initial target of the virus."

"One recent animal study showed that a nasal vaccine could lower viral shedding. Viral shedding is when an infected person releases virus particles into the environment around them (e.g., from a cough). This is how the virus spreads and infects other people. You can also shed the virus before you know you’re sick or infected. That’s why lowering viral shedding is important.

The same study found that a nasal vaccine created more neutralizing antibodies than the shot. Neutralizing antibodies bind to the virus and stop it from multiplying and infecting your cells. But both vaccine types were effective at lowering the amount of virus in the body."

[IbogaProject]

6. UPitt Medical Center had a patch vax ready early 2020

UPitt Medical Center had a patch vax ready early 2020 then they partnered with moderna and shelved their in house skin patch based idea.

The idea is to use sharm glucose spikes that have the proteins on their surface. The immune system in the capillaries is similar to the nose and lungs.


https://www.niaid.nih.gov/news-events/microneedle-patch-covid-19-vaccine

[Blue Owl]

7. Tell Don Jr. it's liquid blow