Largest psilocybin trial finds the psychedelic is effective in treating serious depression

[Klaralven]

Eagerly awaited results of the largest-ever study of psilocybin were announced Tuesday, with Compass Pathways revealing the psychedelic drug was highly efficacious as a therapy for treatment-resistant depression. Still, the company’s stock price dropped 16.4% by the close of trading, perhaps because of safety concerns among investors.

The Phase 2b study is the largest randomized, controlled, double-blind trial of psilocybin, the psychedelic compound in magic mushrooms. The company said it found that patients who were given the highest dose, 25 milligrams, had a significant decrease in depressive symptoms compared to those given 1 milligram, which is such a low dose it functions as a placebo.

Overall, 29.1% of patients in the highest-dose group were in remission three weeks after treatment, compared to 7.6% of those in the control group, and more than a quarter of the patients in the 25-milligram arm were still in remission three months after treatment.

Those who received the highest dose also experienced an average reduction on a measure of clinical depression (the Montgomery-Asberg Depression Rating Scale) that was 6.6 points greater than those who took 1 milligram. Other patients were given a 10-milligram dose, but there was not a statistically significant impact for those patients compared with the 1-milligram arm.

“Everyone agrees such a result hasn’t been seen before in depression research, so we’re incredibly happy with that result,” said Lars Christian Wilde, co-founder and president of Compass.

https://www.statnews.com/2021/11/09/largest-psilocybin-trial-finds-psychedelic-effective-treating-serious-depression/

[OAITW r.2.0]

1. Non-proscribed shrooms gave me great insight on my life.

Last edited Wed Nov 10, 2021, 11:33 PM - Edit history (1)

As did LSD the few times I took a trip. Oh boy, the greatest reality wake-up call I ever had.

[LiberatedUSA]

4. I have never tried them.

Always been afraid of anything that puts you in an alternate reality. However, I understand that this is a bit different than being strung out on meth or something similar. Like the trips are short and they offer more of a mind opening experience than a keep coming back addiction experience.

If under supervision, sober supervision, I would probably try them under legal circumstances just to see what Joe Rogan and others are always talking about.

[OAITW r.2.0]

5. OK, here's my personal drug use quick synopsis

67 - Colt 45 - was a mind fuck. Mainly because of the puking.
69- Pot - Nice buzz. Probably made me susceptible to cigs. Oh well.
70 - Cigs.
72 - Coke - Sure...made my nose and mouth numb. Never bought, but I did snort a line or 3.
73 - LSD - Direct from Owsley. What experiences. As a Jesuit educated male from the mid-60's thru the 70's. LSD was the best sacrament ever. A few dozen trips later, I graduated.
74 - Shrooms - LSD, light.
75-Present Alcohol, Good Bud......in moderation.

[LiberatedUSA]

7. As far as pot...

…Once one doesn’t get the munchies anymore and no longer worries about hitting that curl up into a ball of paranoia note, you can basically walk around high all the time and nobody will know. You’re just the easy going person.

[elevator]

9. I'm an atheist now, but I've had two what i would call religious experiences

one was doing magic mushrooms and the other was when Sister Mary Ruth took me in the cloakroom in sixth grade.

Seriously, every time I did the shrooms I had a several week period of an enhanced appreciation of life. And aspects have carried over to this day.

[BigmanPigman]

2. I thought investors would be more concerned

with the availability of a "pharmaceutical" that can be easily and cheaply grown by Mother Nature. How will they be able to mark the cost up 1,000%?

[SeeingEyeRefugee]

3. Nailed it!!!

Maybe the govt will allow a chemical "cousin" (we will call it "psilo-cyanide-poisonate666&quot .

It only gives really really bad trips, and may cause anal bleeding, tongue warts, bloating, and pink eye...but at least nobody will have fun.

[OAITW r.2.0]

6. Turns out, it is not a great financial model for Big Pharma.

It's not even a great side investment. The more people smoke pot, the less dependent they become on manufactured pharmaceuticals.

[njhoneybadger]

8. There is a very interesting documentary on Netflix, Fantastic Fungi.

https://m.

[Simeon Salus]

10. Some of us could have told you that 40 years ago...

Organic speed puts you into a good mood and doesn't kick back later like pills did.