Monkey Pox info

[AntivaxHunters]

Wellp, it seems that the government is very concerned about Monkey Pox seeing as it just purchased millions of doses of the Small Pox vaccine which treats Monkey Pox. 13 million doses of it no less. https://www.newsweek.com/monkeypox-cased-uk-massachusetts-case-vaccine-ordered-us-1708075

On top of that, BNO News has released its Monkey Pox Tracker.
Their Covid tracker was one of the best before the government changed how Covid cases were reported.
This is great reference material from a source who has busted it's balls these last few years.

For those curious, here's the FDA website about JYNNEOS, the Small Pox vaccine which we're using.
https://www.fda.gov/vaccines-blood-biologics/jynneos

However it's the Drugs.com website which really goes in depth on the JYNNEOS vaccine.
https://www.drugs.com/pro/jynneos.html

[Hugin]

1. I will admit I know little about Monkey Pox.

Off to the Innernet Tubes and put my Anthony Fauci junior web epidemiologist badge to good use.



I mean it could cause the fur to fall off my blue ribbon COVID vaccination handy-dandy prehensile tail for crying out loud. That would be disturbing!

However, now is the time when taking these things seriously is important. Before the football game gets started.

[Joenobody]

2. Monkey pox isnt

The kind of virus that'll cause pandemic, or even an epidemic. Small outbreaks are about it.

It generally has an r0 of less than 1. Plus it doesn't move silently like Covid. You become covered in a rash with large lesions, which is harder to ignore than a sore throat.

[JonAndKatePlusABird]

4. Reminds me of a thought experiment posted here

Or maybe it was Reddit, but it was something I discussed up with friends and family after I read the post…

The question was “how would COVID play out if it manifested itself in skin lesions and other highly visible external symptoms?”

[BumRushDaShow]

5. "Small outbreaks are about it."

And SARS CoV2 was once denied as being a "pandemic" until 3 months after it had been spreading in 114 countries - https://www.who.int/director-general/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020

And then they declared it was not "spread in the air".

Link to tweet

World Health Organization (WHO)
@WHO
FACT: #COVID19 is NOT airborne.

The #coronavirus is mainly transmitted through droplets generated when an infected person coughs, sneezes or speaks.

To protect yourself:
-keep 1m distance from others
-disinfect surfaces frequently
-wash/rub your 👐
-avoid touching your 👀👃👄
Image
2:44 PM · Mar 28, 2020

And we have had 2 years of "goal post moving" regarding everything to do with SARS CoV-2 and the vaccines developed for it.

One of the issues with Monkey Pox, is that just like the Plague bacteria (Yersinia pestis), where prairie dogs (and other rodents) are very susceptible, so too have prairie dogs contracted Monkey Pox (where a small outbreak in the U.S. just over 10 years ago was associated with transmission from pet prairie dogs).

In reality, what epidemiologists and others need to do is MONITOR how this latest viral outbreak is manifesting (just like they are monitoring the so-called "mysterious" Hepatitis outbreak in young children), and not make hasty, rash and loudly conclusionary statements that end up turning out to be wrong.

This is why the public continues to be confused and distrustful of the scientific and Public Health community.

[Hugin]

6. Way to set the record straight, BR.

My cursory investigation so far has revealed the population most susceptible to severe cases of Monkey Pox are young children (fatalities up to 10%!). A group where the chances of transmission are also higher, unfortunately.

So, it bears monitoring.

[BumRushDaShow]

7. One of the transmission vectors

is through "bites" and you do have families with children who have some of the more unusual/"exotic" pets like squirrels, ferrets, certain fancy rats, prairie dogs, chinchillas, minks, etc.

Monkeypox Casts Light on Rule Gap for Exotic Pets

By Jodi Wilgoren

June 10, 2003

The Web site for the federal Department of Agriculture provides guidelines for the importation of pets. Dogs must be vaccinated against rabies. Cats going to Hawaii are to be quarantined for 130 days. Animals like sheepdogs that will be used with livestock have to be free of tapeworm. Then, at the bottom, under ''other,'' is a long list of the animals on which there are no restrictions: fish, reptiles, lions, tigers, bears, monkeys, guinea pigs, rats, chinchillas, squirrels, mongooses, chipmunks, ferrets and other rodents, for starters. That is why, officials say, there appears to be no wrongdoing behind the outbreak of monkeypox in the Midwest that apparently began with a giant pouched rat from Gambia and was passed through prairie dogs to more than 30 people in three states.

The federal Fish and Wildlife Service monitors traffic in endangered species. The federal Centers for Disease Control and Prevention bans the importation of certain animals, like primates, as pets because they are known to cause human diseases like herpes. Animals from countries with problems like foot-and-mouth disease are also regulated. But the rapidly expanding and diversifying exotic pet industry, which experts estimate generates tens of billions of dollars annually, operates largely without federal regulation, leaving a pastiche of state and local rules rife with loopholes. The U.S.D.A. licenses pet dealers but makes no distinction between selling cats and dogs, and hedgehogs and hermit crabs.

Most states allow exotic animals to be traded freely, even in casual settings like swap meets, and few towns require pet owners to keep paperwork even on their pythons or pumas. ''There's all kinds of critters out there'' that few people know much if anything about, said Merritt Clifton, the editor of Animal People, a newspaper with a circulation of 15,000 published 10 times a year from Clinton, Wash. ''They're reproducing prolifically, they're often being abandoned, there are few veterinarians that know how to treat them.'' Beyond the danger of, for instance, large cats let loose in suburban subdivisions, many experts have become increasingly concerned about the spread of disease from exotic animals to the people who keep them.

Long before prairie dogs contracted monkeypox, a virus related to smallpox, they were known to carry bubonic plague. Tortoises often have Amblyomma ticks, which can infect livestock. Reptiles can spread salmonella. And rats are vectors for a host of illnesses. ''Animal health and human health are intimately connected,'' said Donna Gilson, a spokeswoman for the Department of Agriculture in Wisconsin, where most of the monkeypox patients live. Still, while Wisconsin requires certificates of veterinary inspection for every cow, hog, deer or elk imported into the state, it makes no attempt to track small exotics like prairie dogs. ''That would be really difficult to enforce,'' Ms. Gilson said. ''Gosh, you can have those in a box in the back of your hatchback.''

(snip)

https://www.nytimes.com/2003/06/10/us/monkeypox-casts-light-on-rule-gap-for-exotic-pets.html

I won't even bring up the ongoing bird flu happening at that moment.

[LeftInTX]

9. I'm surprised that they're saying Monkey Pox is mostly spread through sexual contact...

I'm like, "Huh? Isn't it spread the same way that small pox is spread?"

Well, I don't know too much about small pox transmission because that was before my time, but still...I always thought it was airborne..but who knows?

Although I'm immunized against small pox, the vaccine probably does not provide lifetime immunity...

[BumRushDaShow]

12. "I'm surprised that they're saying Monkey Pox is mostly spread through sexual contact..."

To me it sounded like a homophobic slur type statement and I expect that this "conclusion" may have been due to a cluster of infected in the UK who were from the LGBTQ community - https://www.yahoo.com/now/first-u-monkeypox-case-confirmed-180918378.html

[Joenobody]

10. We had a few weeks of data on Covid

We've known about monkeypox since the 50s.

[LeftInTX]

11. I think monkeypox is spread the same as smallpox...

[Joenobody]

14. But it is

Less transmissible.

I also don't think anyone is trying to say it is sexually transmitted, but having sex with someone with it would out that person into the type of close personal contact that would make spreading it likely.

[BumRushDaShow]

15. What "few weeks of data"?

It is now over 2 1/2 years later, we are going through what is a 7th wave, and are still arguing about "masks".

And as a note, "coronaviruses" have been around for probably eternity and there was a previous outbreak of what was dubbed "SARS CoV-1" over a decade ago (2003), where much of the research on the current vaccines for SARS CoV-2, came as a result of that earlier outbreak of SARS CoV-1, and that is why the current vaccines came out so quickly.

Coronaviruses are part of a group of viruses that co-mingle with rhinoviruses and others that make up the "common cold", but can obviously mutate into something pretty nasty.

[Joenobody]

17. Moving the goalposts

You were talking about saying covid wasn't spread throw air, and now we're talking about mask mandates today? No expert I suggesting covid isn't airborne or rhat masks would reduce spread. They are looking at risks roboiblic health, which are nor the same as they were 2 years ago.

When the statement you quoted was made, we had weeks worth of data on covid. And while there are other coronavirus, they don't all behave the same way. SARS and MERS for example are not as easily spread, hence why they never became wider problems.

And all of that is still irrelevant to monkeypox.

[BumRushDaShow]

18. What are you talking about?

Read my original post again.

You were talking about saying covid wasn't spread throw air, and now we're talking about mask mandates today?

And you didn't read the rest of why I used that as an example. I will repeat it again -

In reality, what epidemiologists and others need to do is MONITOR how this latest viral outbreak is manifesting (just like they are monitoring the so-called "mysterious" Hepatitis outbreak in young children), and not make hasty, rash and loudly conclusionary statements that end up turning out to be wrong.

This is why the public continues to be confused and distrustful of the scientific and Public Health community.

When the statement you quoted was made, we had weeks worth of data on covid.

This is absolutely incorrect.

As I noted earlier, there were YEARS worth of data associated with SARS CoV-1, which was the predecessor to the current "SARS CoV-2 (why the hell do you think the virus that is associated with COVID-19 is called "SARS CoV-2" or maybe you didn't know that? ). Here is one such paper -

Evidence of Airborne Transmission of the Severe Acute Respiratory Syndrome Virus
List of authors.

Ignatius T.S. Yu, M.B., B.S., M.P.H., Yuguo Li, Ph.D., Tze Wai Wong, M.B., B.S., Wilson Tam, M.Phil., Andy T. Chan, Ph.D., Joseph H.W. Lee, Ph.D., Dennis Y.C. Leung, Ph.D., and Tommy Ho, B.Sc.


April 22, 2004
N Engl J Med 2004; 350:1731-1739
DOI: 10.1056/NEJMoa032867


Abstract


Background

There is uncertainty about the mode of transmission of the severe acute respiratory syndrome (SARS) virus. We analyzed the temporal and spatial distributions of cases in a large community outbreak of SARS in Hong Kong and examined the correlation of these data with the three-dimensional spread of a virus-laden aerosol plume that was modeled using studies of airflow dynamics.
Methods

We determined the distribution of the initial 187 cases of SARS in the Amoy Gardens housing complex in 2003 according to the date of onset and location of residence. We then studied the association between the location (building, floor, and direction the apartment unit faced) and the probability of infection using logistic regression. The spread of the airborne, virus-laden aerosols generated by the index patient was modeled with the use of airflow-dynamics studies, including studies performed with the use of computational fluid-dynamics and multizone modeling.
Results

The curves of the epidemic suggested a common source of the outbreak. All but 5 patients lived in seven buildings (A to G), and the index patient and more than half the other patients with SARS (99 patients) lived in building E. Residents of the floors at the middle and upper levels in building E were at a significantly higher risk than residents on lower floors; this finding is consistent with a rising plume of contaminated warm air in the air shaft generated from a middle-level apartment unit. The risks for the different units matched the virus concentrations predicted with the use of multizone modeling. The distribution of risk in buildings B, C, and D corresponded well with the three-dimensional spread of virus-laden aerosols predicted with the use of computational fluid-dynamics modeling.

Conclusions

Airborne spread of the virus appears to explain this large community outbreak of SARS, and future efforts at prevention and control must take into consideration the potential for airborne spread of this virus. Hong Kong was the hardest-hit area during the worldwide epidemic of infection with the severe acute respiratory syndrome (SARS) virus in 2003, with the highest incidence rate (1755 cases in a population of 6.7 million) and a high case fatality rate of 17 percent (299 deaths).1 In fact, the infection in Hong Kong was believed to be the source of the spread of the disease to many other countries.2 A series of case clusters that occurred during the epidemic in Hong Kong2-6 suggested that environmental factors might have been involved in the spread of the virus.

(snip)

https://www.nejm.org/doi/full/10.1056/nejmoa032867

CDC has a timeline of discovery of it - https://www.cdc.gov/museum/timeline/covid19.html

On January 22, 2020 when W.H.O. met, they refused to call it a "pandemic".

They met a little over a week later and STILL didn't call it a pandemic (although they had evidence it was spreading). Meanwhile the U.S. had started gearing up.

A few more weeks later, W.H.O. names the "disease" caused by SARS CoV-2 "COVID-19" but STILL hadn't declared it a "pandemic".

It wasn't until March 11, 2020 when it was declared "a pandemic".

The point of this is that "scientists", the "medical community" (including researchers in both types of fields and I happen to be a retired chemist by the way), and Public Health officials, tend to "tunnel vision" their interpretations of the SAME data based on their "expertises" and when doing so, have essentially botched the response to this COVID-19 pandemic.

And given that same "tunnel vision" exists for many other diseases - particularly viral ones that are often difficult to treat, one should not go along the same path when dealing with "sudden outbreaks" (like Monkey Pox) in this COVID-19 environment, where odd mutations can and have happened to make something "more transmissible".

And an example of a swing and a miss was the last "outbreak" of a bird flu (not associated with the current one) that lead to an expectation of and preparation for an avian flu pandemic that lead to a miss of what eventually became a swine flu pandemic instead.

As it is, the ultimate illustration of "disagreements", in a somewhat related subject given the vaccine to be used for the Monkey Pox outbreak, was the earlier "declaration" that "smallpox was eradicated", and the subsequent years of debate that ensued over the past couple decades about destroying the last of the smallpox samples.

Point being that the unfortunate aspect of a natural discord within a scientific and medical community, can exasperate the manner of dealing with pathogens that impact humans.

[Takket]

13. Holy fucking shit

I’d never seen that statement. Hopefully whoever wrote that was fired. It is terrifying that someone at the WHO apparently doesn’t know what it means for a virus to be airborne.

[BumRushDaShow]

16. This pandemic

has been mishandled, around the world, literally from day one. So many of our scientists and medical experts are, by design, so "specialized" (by training), that they get trapped in a "tunnel vision" absolutist view of certain data and have to be dragged kicking and screaming out of it.

It's to the point that instead of accepting "shades of gray" it becomes the argument of "Tastes great!" / "NO! Less filling!"

So when someone talks or sneezes, then one side will say -

"IT'S ALL BIG DROPLETS AND DOESN'T GO AIRBORNE BEYOND 6 FEET!!!1111!!!!"

and the other side says -

"NO!!!!! IT'S ALL AEROSOLIZED AND MASKS ARE USELESS!!!1!!!1!"

[BumRushDaShow]

3. "JYNNEOS" a/k/a "Imvamune"

https://www.cdc.gov/smallpox/clinicians/vaccines.html

These vaccines were supposedly in the National Stockpile - and per the OP link, am guessing the new orders will be to further process what was already contracted (from what is already in inventory/set aside in the stockpile) into doses -

(snip)

The order will convert bulk vaccines, which have already been made and invoiced under previous contracts with the U.S. government, into freeze-dried versions which have an improved shelf-life.

The total government contract with Bavarian Nordic amounts to $299 million, which would provide 13 million freeze-dried doses.

https://www.newsweek.com/monkeypox-cased-uk-massachusetts-case-vaccine-ordered-us-1708075

And as noted, these small pox vaccines offer some protection to other poxes like the subject monkey pox (and related cow pox and horse pox)- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565152/

What you should know about smallpox in the post-eradication era :


December 1, 2016

H. Cody Meissner, M.D., FAAP

(snip)

Smallpox vaccines do not contain variola virus, the causative agent of smallpox. Instead, they are made from the related vaccinia virus, which induces a protective immune response against smallpox.

The Food and Drug Administration licensed a new smallpox vaccine in 2007 (ACAM2000), which replaced the previously licensed vaccine (Dryvax). Two other smallpox vaccines at the Strategic National Stockpile are Aventis Pasteur smallpox vaccine (WetVax) and Imvamune.

WetVax is a liquid formulation of a live vaccinia virus similar to the lyophilized smallpox vaccine, Dryvax. ACAM2000 and WetVax are administered by scarification (percutaneous route) using 15 jabs of a bifurcated needle that has been dipped in the vaccine. The live smallpox vaccine provides a high level of immunity for three to five years with decreasing immunity after that, but some protection against death may last 30 years.

Imvamune is a third-generation, non-replicating smallpox vaccine for use in healthy populations as well as people with immune disorders or pre-existing skin conditions such as atopic dermatitis and who cannot be safely vaccinated with a live smallpox vaccine. Imvamune requires two doses, four weeks apart and is administered subcutaneously.

https://publications.aap.org/aapnews/news/14887

[madville]

8. That smallpox vaccine I got in 2016 is finally

Gonna pay off. It says it can provide protection for decades even though effectiveness starts decreasing after 3-5 years.