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Fri Oct 25, 2013, 07:57 PM

Marijuana Compounds Can Kill Some Cancer Cells: Study

Studies continue to indicate anti-cancer properties for cannabinoids. Again, this is not about smoking cannabis, but about moving cannabis from a Schedule I designation so that more studies on the potential medical uses for cannabinoids can proceed without interference from drug warriors who have a stake in protecting turf, not scientific and medical inquiry.

http://www.huffingtonpost.com/2013/10/25/marijuana-cancer_n_4158865.html

A scientist in the United Kingdom has found that compounds derived from marijuana can kill cancerous cells found in people with leukemia, a form of cancer that is expected to cause an estimated 24,000 deaths in the United States this year.

"Cannabinoids have a complex action; it hits a number of important processes that cancers need to survive," study author Dr. Wai Liu, an oncologist at the University of London's St. George medical school, told The Huffington Post. "For that reason, it has really good potential over other drugs that only have one function. I am impressed by its activity profile, and feel it has a great future, especially if used with standard chemotherapies."

During the study, Liu and his team grew leukemia cells in a lab and cultured them with increasing doses of the six pure cannabinoids, both individually and in combination with each other. His study says the six cannabinoids were CBD (Cannabidiol), CBDA (Cannabidiolic acid), CBG (Cannbigerol), CBGA (Cannabigerolic acid), CBGV (Cannabigevarin) and CBGVA (Cannabigevaric acid). Liu and his team then assessed the viability of the leukemia cells and determined whether or not the cannabinoids destroyed the cells or stopped them from growing.

..."Cancer is an umbrella term for a range of diseases that fundamentally differ in their cellular makeup, [and] which occur as a result of disturbances to growth controls," Liu said. "Chemotherapy works by disrupting these dysfunctional growth signals. Therefore, any cancers that have these profiles should respond to the chemotherapy. It just so happens that a number of cannabinoids can target these very same mechanisms that make cancer what it is, and so any cancer that exhibits these faults should respond well to cannabinoids. The flip side is, of course, that other cancers may not have these same genetic faults and so cannabinoids may not work as well."


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Reply Marijuana Compounds Can Kill Some Cancer Cells: Study (Original post)
RainDog Oct 2013 OP
Uncle Joe Oct 2013 #1
RainDog Oct 2013 #9
Uncle Joe Oct 2013 #32
Ghost in the Machine Oct 2013 #2
pacalo Oct 2013 #7
RoccoR5955 Oct 2013 #13
arthritisR_US Oct 2013 #16
pacalo Oct 2013 #21
arthritisR_US Oct 2013 #23
pacalo Oct 2013 #30
roody Oct 2013 #22
arthritisR_US Oct 2013 #24
CoffeeCat Oct 2013 #33
Buddha_of_Wisdom Oct 2013 #35
roody Oct 2013 #42
Ghost in the Machine Oct 2013 #27
pacalo Oct 2013 #29
MattBaggins Oct 2013 #3
RainDog Oct 2013 #10
99th_Monkey Oct 2013 #28
RainDog Oct 2013 #11
TeamPooka Oct 2013 #4
arthritisR_US Oct 2013 #25
Phlem Oct 2013 #5
ReRe Oct 2013 #6
wildbilln864 Oct 2013 #8
DeSwiss Oct 2013 #12
RainDog Oct 2013 #14
DeSwiss Oct 2013 #20
arthritisR_US Oct 2013 #26
CoffeeCat Oct 2013 #34
DeSwiss Oct 2013 #38
RainDog Oct 2013 #36
RandiFan1290 Oct 2013 #37
RainDog Oct 2013 #41
DeSwiss Oct 2013 #39
RainDog Oct 2013 #40
DeSwiss Oct 2013 #43
BluegrassStateBlues Oct 2013 #15
panader0 Oct 2013 #17
RainDog Oct 2013 #19
gopiscrap Oct 2013 #18
intaglio Oct 2013 #31

Response to RainDog (Original post)

Fri Oct 25, 2013, 08:15 PM

1. Kicked and recommended.

Thanks for the thread, RainDog.

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Response to Uncle Joe (Reply #1)

Fri Oct 25, 2013, 09:59 PM

9. Thanks, Uncle Joe

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Response to RainDog (Reply #9)

Sat Oct 26, 2013, 02:11 PM

32. It's amazing how demonizaition of such a beneficial plant has curtailed science;

from studying its' many positive aspects for so long no doubt costing thousands if not hundreds of thousands of suffering people their lives.



Peace to you, RainDog.

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Response to RainDog (Original post)

Fri Oct 25, 2013, 08:18 PM

2. Here's a good link to some U.S. studies, backed by the National Institute on Health..

The Studies

Marijuana Fights:

Heart Disease
Cancer
Diabetes
Osteoporosis
Alzheimer's
Liver Disease
Epilepsy
Skin Allergies
Post Traumatic Stress Disorder
Anxiety and Depression

and is also Neuroprotective and Causes Neurogenesis (brain cell growth)


Why is this scientific evidence any better than hearsay? Aren't these scientists always disagreeing anyway? It's all just fashion...
It is unfortunate that many laymen still have this horrific misunderstanding of science after graduating from grade school. Science is the pursuit of truth that lies outside of human interference, opinion and bias. Everything about science is designed to eliminate the adulteration of human perception. Is it perfect and without mistake? No, but it is tens of thousands of times more reliable than anything else. Humanity has not yet learned everything in the universe but with the help of science we are slowly making our way there. Wihtout the strict processes, examination and re-examination of data that is required for real science, we would be forever stuck in the dark ages ruled over by tyranny or anarchy. We would still be blundering in the dark and dying by the age of thirty. When I hear words like the question above uttered, I nearly want to weep for what it portends. Science as a community does it's best to find the truth and is sometimes wrong anyway. It's rare and usually quite a small thing but when we discover we are wrong we immediately change. Every single person in the scientific comunity would love to find where accepted science is wrong because of the pride and recognition that comes with such a discovery. Millions of people all diligently looking for any little corner where we might be wrong with great reward to be had if they find it. Consider the opposite: millions of people all trying to defend a concept's rightness with death being the punishment for mentioning a possible flaw.


What do each of these "studies" represent?
When a research department at some university wishes to conduct a study they must put together a very comprehensive plan for how it will be accomplished; what it will prove and how that information will be valuable. This proposal is then given to number of institutions with a vested interest in the advancement of knowledge and they will not just hand over a gigantic sum of money to a bunch of unprepared or unprofessional amatuers.
Each study below represents tens of thousands of dollars and untold man hours. Each study is a huge investment of passion and a reflection upon each of the researchers, but the pressure to perform has only just started once the grant has come through. If the results of the study are not published in a reputable peer-reviewed journal, all of the time and money is utterly wasted and thrown in the trash because without publication, the scientific community will reject any findings of the study. This kind of gigantic waste can lay waste to a research department and the careers of all the researchers involved. Needless to say, it is critical for the study to pass the peer-review process.

The peer-review process requirement of publication in a journal is put in place as a way for other professionals in the same area of science to review the processes undertaken by the study. These reviewers assure not only that there is not blatent twisting of facts but also that experimenter bias is accounted for and that pre-concieved notions can have not even an accidental effect on the outcome of the study. They also assure that the conclusions drawn from the data do not include anything presumtuous.

When only one study points to a particular new understanding it is a very significant consideration for being truth. When multiple studies point to the same thing, it is as close to absolute, factual, unbiased, immutable, truth as humanity is or will ever be capable of grasping.

http://www.scientificfactsofpot.com/studies.htm


Peace,

Ghost

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Response to Ghost in the Machine (Reply #2)

Fri Oct 25, 2013, 09:55 PM

7. It dulls the pain of arthritis, too.

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Response to pacalo (Reply #7)

Fri Oct 25, 2013, 10:29 PM

13. And the pain of sciatica. n/t

 

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Response to pacalo (Reply #7)

Fri Oct 25, 2013, 10:41 PM

16. Sure does and it was a godsend for my husband

in his last months, the narcotics were only helpful to a point. I think it gave him a measure of quality of life back.

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Response to arthritisR_US (Reply #16)

Fri Oct 25, 2013, 11:25 PM

21. I'm so glad your late husband was able to acquire it because it takes away the pain

like nothing else does. I'm sorry, though, about his passing.

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Response to pacalo (Reply #21)

Sat Oct 26, 2013, 12:15 AM

23. I couldn't get it legally because he was diagnosed in

Feb and was only given 6 months, the process takes up to 24 months. His pain was horrendous from the start so good mates got it for me within a week. You could see the pain visibly drain from his face and he would laugh and converse with such clarity and ease. My right wing sister would even tell me at times that she thought he was in need of a joint. It truly was a blessing and even though it has only been a month since he passed I am grateful I reached out to others who got it for me so I could help him, he sure appreciated it!

P.S. Thank you for your kind thoughts

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Response to arthritisR_US (Reply #23)

Sat Oct 26, 2013, 02:17 AM

30. ...

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Response to pacalo (Reply #7)

Sat Oct 26, 2013, 12:02 AM

22. It gives me the energy to walk

my dogs after working on my feet all day.

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Response to roody (Reply #22)

Sat Oct 26, 2013, 12:20 AM

24. I believe that completely! It's time for the stigma to

be removed!

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Response to roody (Reply #22)

Sat Oct 26, 2013, 07:03 PM

33. Really?

I'm very interested in this. So, marijuana gives you energy? I remember smoking it in high school/college in the late 70's/early 80's, and I remember feeling relaxed. I don't remember feeling energized, although I felt really great!

I've heard that mj has changed a great deal from those times though.

Glad that people are experiencing medicinal benefits from it. Whatever works.

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Response to CoffeeCat (Reply #33)

Sat Oct 26, 2013, 07:18 PM

35. three subtypes of marijuana

 

Sativa - which gives you energy and tickly feeling
Indica - gives you relaxing feeling and sometimes a sleepy one
Rudica - crappy ditchweed that Mexicans bring in to sell as 'weed'.

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Response to CoffeeCat (Reply #33)

Sun Oct 27, 2013, 12:04 AM

42. Yes. It used to inspire me to clean

house.

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Response to pacalo (Reply #7)

Sat Oct 26, 2013, 12:28 AM

27. Oh, I know that firsthand :-)



Peace,

Ghost

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Response to Ghost in the Machine (Reply #27)

Sat Oct 26, 2013, 02:10 AM

29. Backatcha, Ghost.

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Response to RainDog (Original post)

Fri Oct 25, 2013, 08:35 PM

3. While it is perfectly reasonable to advocate for marijuana reform

do keep in mind that everything kills cancer cells in a petri dish.

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Response to MattBaggins (Reply #3)

Fri Oct 25, 2013, 10:02 PM

10. Cannabinoids have shown they shrink tumors in mice, and humans

for one type of cancer - gliomas, or brain cancer.

this was after conventional treatments had failed for the human subjects.

This is part of the cutting edge of new treatment. The govt. should remove cannabis from schedule I and allow an explosion of research and development related to the amazing medical properties of cannabinoids.

I'm just sharing something that might be of interest to forward-thinking DU-ers.

Take from it what you will.

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Response to RainDog (Reply #10)

Sat Oct 26, 2013, 02:01 AM

28. +100 Thank u. ~nt~

 

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Response to MattBaggins (Reply #3)

Fri Oct 25, 2013, 10:11 PM

11. to say, again

the reality is that cannabinoid medicine will come from regular pharmaceutical channels. This is already happening, in fact.

Yesterday, as well, the FDA announced approval for a study for the treatment of a particularly devastating form of epilepsy for which there are no current medications that help many people who suffer from this.

http://www.democraticunderground.com/11701420

FDA Approves Investigational Trials Assessing Cannabidiol for Pediatric Epilepsy

Gupta's recent report on CNN seems to be having positive effects on the govt's previous intransigence regarding cannabis medicine studies since he highlighted the stories of children who went from non-functional to few or no seizures.

In the past, without wide media exposure, such studies were often left unapproved because of claim that cannabis has no medical value.

This claim has been thoroughly debunked and it's time for Congress to stop pretending the current drug schedule is anything more than a knee-jerk reaction to standard stoner stereotypes.

There's a whole other world out there that has nothing to do with Cheech and Chong.



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Response to RainDog (Original post)

Fri Oct 25, 2013, 08:46 PM

4. Prohibition is a failed public policy. nt

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Response to TeamPooka (Reply #4)

Sat Oct 26, 2013, 12:21 AM

25. You speak the truth! n/t

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Response to RainDog (Original post)

Fri Oct 25, 2013, 09:45 PM

5. K&R!

and bookmarked!



-p

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Response to RainDog (Original post)

Fri Oct 25, 2013, 09:52 PM

6. I heard about this this week...

K&R

Move the Schedule I designation now.

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Response to RainDog (Original post)

Fri Oct 25, 2013, 09:59 PM

8. k & r! n/t

 

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Response to RainDog (Original post)

Fri Oct 25, 2013, 10:24 PM

12. K&R

 

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Response to DeSwiss (Reply #12)

Fri Oct 25, 2013, 10:33 PM

14. the pharmas have moved past single compounds

or at least the ones doing the most research have.

And the compound that has shown the most medical promise is CBD, which is non-psychotropic.

But, ultimately, the researchers are recognizing the synergistic activity of THC, CBD and other cannabinoids.

The stuff that's awaiting approval for the American market is actual cannabis, not a synthetic, which is a combination of indica, sativa and ruderalis strains. (two of these are higher in CBD than the other.)

the plant material is ground, reduced in a liquid solvent, and used as a spray under the tongue for things like epilepsy, MS, CP, etc.

And the case that was in the news recently, the kid with brain cancer - I'm hoping that will spark interest in FDA approval for other studies.

http://www.democraticunderground.com/?com=view_post&forum=1002&pid=3875341

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Response to RainDog (Reply #14)

Fri Oct 25, 2013, 10:55 PM

20. I know what cannabis can do, first hand.

 

- I'm making my weekly batch of cannaoil as we speak. I have no use for their knock-offs.

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Response to DeSwiss (Reply #20)

Sat Oct 26, 2013, 12:23 AM

26. Could you please IM me how to do that? n/t

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Response to DeSwiss (Reply #20)

Sat Oct 26, 2013, 07:06 PM

34. What do you use it for?

Is the oil medicinal, in general, like herbs or other antioxidants that have healing properties?

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Response to CoffeeCat (Reply #34)

Sat Oct 26, 2013, 07:52 PM

38. Primarily the pain and degenerative effects of peripheral neuropathy, sciatica and arthritis.

 

I make Cannaoil using grape seed oil as the base. I've also made an Cannabis Tincture (from grain alcohol) but I'm not as skilled with that process. I've only been at it since June but the effects and benefits are beyond question. I've slowed the process but I live in a backwards state with no medicinal cannabis law. Ti get the best and fullest effects from cannabis, you have to consume it like any other food. Here's more info I recently sent to someone else asking about the process:

    First you need to know some cannabis science. I found most of that years ago in foreign medical journals and databases because politics in this country suppressed open research for so long. Since the mid-1970s. They knew.

    As for medicinal cannabis, CBDs are what kills cancer and helps restore immune/nervous system health. For this compound as well as the CBDa's you don't need the high THC-content cannabis. There are now strains with hardly any THC-psychoactive ingredients, but are high CBD percentage in the ''sugar'' leaves and the tender stems. Even the roots can be ingested. It is juiced. It's chopped up into salads. It's cooked with food like any other herb would be.

    THCs in cannabis on the other hand is what is mostly available in those states that have no medical-cannabis laws. Street stuff in other words. Which can be a problem if you're making your own oil when you can't vouch that the cannabis doesn't come laden with pesticides or growth hormones which are often used in the illegal recreation-cannabis trade. Only if you grow it yourself, or know the grower can you be certain of high quality cannabis that would meet medical standards.

    The THCs in cannabis also have medicinal value. It is what helps with pain, anxiety, nausea and eating disorders. It's now being touted by even the feds as particularly useful in dealing with hard to treat pain. Like the kind I have from peripheral neuropathy. There are very few effective conventional medical treatments, and many with this disease end up on opiates. Some also have poor circulation problem as their muscles atrophy and may lose feet or legs from ulcers caused by the disease. But I use something else to help with that, so my feet and legs are very healthy.

    START:

    Cannabis Science - How Marijuana Affects Health - Educational Documentary


    LEAF


    LINKS:

    Medical Marijuana Neuropathy Treatments | Cannabis Symptom Relief
    http://medicalmarijuana.com/medical-marijuana-treatments/Neuropathy

    https://legalmarijuanadispensary.com/medical-marijuana-community

    http://www.marijuana.com/

    OTHER YOUTUBE WORKERS IN THE VINEYARD:

    Watermelon - (Knows her chops and has good food recipes and medical use info)
    http://www.youtube.com/user/Bakingafoolofmyself?feature=playlist

    Stoner Girl - How To Make Cannabis Butter (Marijuana Butter / Cannabutter / P


    Watermelon - Salmon & Asparigrass


    Watermelon - New Cannabis Conversions Original


    Making Cannabis Juice with Matt Rize


    How to Make a Small Batch of Rick Simpson Oil


    ALSO:

    I also use DMSO as a penetrant to direct the cannabis oil more specifically. It's not for everybody, but it is used by some for arthritis pain. DMSO is a naturally occurring compound and like cannabis is not patentable. Which explains the disinterest in it, in-part. DMSO, like cannabis, is a direct threat to Big Pharma. DMSO allows for the penetration of medicinals without the use of needles and can be directed at specific areas under treatment, thereby significantly reducing the amounts of medicines needed. It is currently approved by the FDA for use in the preservation of organs for transplant, and the treatment of interstitial cystitis.

    It is interesting to note that both Cannabis and DMSO (among just a few natural substances) are used in hospitals all over world, but not in America. Where the FDA prostitutes only approve what their pimp daddies at the pharmaceutical companies tell them they can approve.

    The discoverer of DMSO's health benefits is Dr. Stanley Jacob whose website (http://www.dmso.org/) has a great deal more info. It was his lab in the early 1960s that discovered that DMSO was the perfect substance to preserve organs so that transplants could take place almost anywhere. Prior to this discovery, all transplants required that the donor and recipient be in the same place at the same time. DMSO changed all that. Below is a news report from Mike Wallace at 60 Minutes done in 1968 concerning DMSO:







    Good luck!

    ~DeSwiss

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Response to DeSwiss (Reply #20)

Sat Oct 26, 2013, 07:28 PM

36. ...




the problem, for people who hear about these things, is that creating oil can be a dangerous process and I wouldn't encourage anyone to do such a thing.

I'm just in "mom mode" as far as safety goes, and in recognizing how the medical community approaches such things - they work within a particular mindset (that often serves us well, as far as caution), and, for more people to be able to access the medical benefits, cannabis will have to go through a process with the FDA to meet certain conditions, etc.

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Response to RainDog (Reply #36)

Sat Oct 26, 2013, 07:44 PM

37. Have you seen the CO2 extraction?

Now you can get organic oil and avoid the dangerous solvents

http://www.organalabs.com/index.htm

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Response to RandiFan1290 (Reply #37)

Sat Oct 26, 2013, 09:55 PM

41. that sounds like a better way to go

of course, the shake is all from concentrated THC strains, I would imagine, which breeds out CBD.

The thing about such an oil, for medical purposes, it that both strains can be combined for maximum benefit of both compounds - because both have health functions and they work together.

this is an interesting time in history to be alive, as this is a major paradigm shift as decades of populist work has laid the groundwork for scientific work - and undermined the drug warriors' hysteria of the last century.

Seventy years of propaganda, undone by twenty years of free access to information via the internet and the first passage of medical marijuana laws.

I hope I live to see this nation become less and less reactionary about a host of issues. That is a good goal.

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Response to RainDog (Reply #36)

Sat Oct 26, 2013, 07:55 PM

39. What you're referring to is Rick Simpson Oil.

 

- I'm not referring to that, nor do I make it. The Cannaoil I make uses no flammable solvents of any kind. See my post above for more info.

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Response to DeSwiss (Reply #39)

Sat Oct 26, 2013, 09:48 PM

40. gotcha

I was thinking about the very, very potent cannabis oil via solvent - potent, as in containing a large concentration of cannabinoids, even tho they may not have a psychotropic effect, as a form of medicine for particular issues related to diseases.

one of these days I'm gonna do some field research... lol. As it is, I'm just reporting what I see from the sidelines.

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Response to RainDog (Reply #40)

Sun Oct 27, 2013, 01:18 AM

43. The Cannaoil......

 

...I'm referring to is also very potent but it is achieved by increasing the cannabinoids potency levels via heating. Simpson oil also uses heat but only after a solvent has been used to extract the cannabinoids. The solvent is then evaporated with high heating (no higher than 290 degrees) leaving only the tar-like oil residue. One only needs small amounts using this approach which is another reason for it's appeal. Simpson Oil is a highly concentrated form of Cannaoil.



The reason oil or fat is used (see Watermelon's recipes) is because THCs are fat-soluble. And it is the heating that increases the potency as well as allows for the release or the ''decarboxylating'' of the cannabinoids. This heating process becomes the focus of concern when someone (trying to make Rick Simpson Oil) who doesn't not know what they're doing, exposes the solvent admixture to too much heat or open flame, and causes an explosion/fire. In any event, any heating of the cannabinoids above 290 degrees renders the whole mess inert crap.

An alternate way is to use a slow cooker to slowly extract the THC and infuse the oil one is using with the cannabinoids. A finely ground up cannabis is heated at around 225-250 degrees for 4-5 hours. Some patients prefer making tinctures or Simpson Oil, but one can avoid the heating steps altogether by allowing the solvent to escape naturally (slowly) through air evaporation. And some cannabis patients (the explosion-averse) do just this by keeping some resin is various stages of air-evaporation completion. This way takes around 3-4 weeks for the evaporation to take place, but heating it is still possible if one wishes to increase the potency.

There are also other solvents which can be used to extract cannabinoids that are nonflammable. DMSO is a solvent which extracts cannabinoids quite easily. This mixture can be added to pure aloe vera gel to achieve a Cannabis Gel which is excellent for relieving pain quite quickly. With the use of DMSO one doesn't require such a high cannabis potency level because the DMSO allows for the direct penetration the cannabinoids through all muscle tissue in the body. And the DMSO itself relieves pain as well as being highly anti-oxidant and causing blood vessels to dilate thereby improving blood circulation.

If one lives in a forward-thinking state or city with medical-cannabis laws, one may eat it. Literally. In point of fact, juicing, eating, and cooking with cannabis is one of the best ways to consume the non-psychoactive CBDs in cannabis (see the video ''LEAF'' above). CBDs are generally in smaller quantities on the cannabis plant compared to the THC. Unless it is one of the newer strains that has been created specifically to generate higher levels of CBDs.

CBDs don't get you high. They get you well.

Take care.

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Response to RainDog (Original post)

Fri Oct 25, 2013, 10:33 PM

15. Long overdue for legalization. nt

 

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Response to RainDog (Original post)

Fri Oct 25, 2013, 10:42 PM

17. I'm gonna live forever!

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Response to panader0 (Reply #17)

Fri Oct 25, 2013, 10:48 PM

19. ...some of youse guys

....are funny.

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Response to RainDog (Original post)

Fri Oct 25, 2013, 10:45 PM

18. Excellent

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Response to RainDog (Original post)

Sat Oct 26, 2013, 05:30 AM

31. I am tempterd to say ...

"good shit, Sherlock"

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