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Related: Editorials & Other Articles, Issue Forums, Alliance Forums, Region ForumsAlzheimer's type dementia clinical trial, still recruiting
http://www.clinicaltrials.gov/ct2/show/NCT01479855?term=alzheimer%27s+vitamin+d&rank=7The purpose of the study is to compare the concentrations of Vitamin B1 (thiamine), Vitamin B6 (pyridoxal-5-phosphate), folate, Vitamin B12 (cobalamin), Vitamin C (ascorbic acid), Vitamin A (retinol), Vitamin E (alfa-tocopherol), homocystein, uric acid, F2 8-?-isoprostane, 8-deoxyguanosine, retinoids, tau-protein and ?-amyloid in spinal fluid, metabolomics, proteomics, m-RNA for DNA repair enzymes and DNA in patients who suffer from mild cognitive impairment (MCI) or mild dementia of Alzheimers type, with healthy controls.
A second aim is to explore the association between vitamin and nutrient reductions, if any, and cognitive function as well as vascular score and possible changes in the MRI.
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Alzheimer's type dementia clinical trial, still recruiting (Original Post)
DocwillCuNow
Aug 2014
OP
Shhhh, they know what they are doing.... however they might want to take a look at this
DocwillCuNow
Aug 2014
#3
pipoman
(16,038 posts)1. I see no mention of vitamin D which recently has been associated with alzheimer
Like dementias...
RagAss
(13,832 posts)2. You beat me too it....
I was just about to mention the vitamin D deficiency studies.
DocwillCuNow
(162 posts)3. Shhhh, they know what they are doing.... however they might want to take a look at this
http://chriskresser.com/b12-deficiency-a-silent-epidemic-with-serious-consequences
Why is B12 deficiency so under-diagnosed?
B12 deficiency is often missed for two reasons. First, it’s not routinely tested by most physicians. Second, the low end of the laboratory reference range is too low. This is why most studies underestimate true levels of deficiency. Many B12 deficient people have so-called “normal” levels of B12.
Yet it is well-established in the scientific literature that people with B12 levels between 200 pg/mL and 350 pg/mL – levels considered “normal” in the U.S. – have clear B12 deficiency symptoms. Experts who specialize in the diagnosis and treatment of B12 deficiency, like Sally Pacholok R.N. and Jeffery Stewart D.O., suggest treating all patients that are symptomatic and have B12 levels less than 450 pg/mL. They also recommend treating patients with normal B12, but elevated urinary methylmalonic acid (MMA), homocysteine and/or holotranscobalamin (other markers of B12 deficiency).
Why is B12 deficiency so under-diagnosed?
B12 deficiency is often missed for two reasons. First, it’s not routinely tested by most physicians. Second, the low end of the laboratory reference range is too low. This is why most studies underestimate true levels of deficiency. Many B12 deficient people have so-called “normal” levels of B12.
Yet it is well-established in the scientific literature that people with B12 levels between 200 pg/mL and 350 pg/mL – levels considered “normal” in the U.S. – have clear B12 deficiency symptoms. Experts who specialize in the diagnosis and treatment of B12 deficiency, like Sally Pacholok R.N. and Jeffery Stewart D.O., suggest treating all patients that are symptomatic and have B12 levels less than 450 pg/mL. They also recommend treating patients with normal B12, but elevated urinary methylmalonic acid (MMA), homocysteine and/or holotranscobalamin (other markers of B12 deficiency).
pipoman
(16,038 posts)4. lol...shhhh...but, I know what they are forgetting...
