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mobeau69

(11,076 posts)
Wed Apr 29, 2020, 08:53 AM Apr 2020

Breaking News Gilead Remdesivir Trial for Covid-19 Has Met Primary Endpoint

Source: Bloomberg News

Gilead Sciences said it's aware of positive data emerging from the National Institute of Allergy and Infectious Diseases' study of the investigational antiviral remdesivir for the treatment of COVID-19, Bloomberg News reports.

The shares of the company are halted. More information is available on the Bloomberg Terminal.

Developing...

Update:https://www.bloomberg.com/news/articles/2020-04-29/gilead-remdesivir-trial-for-covid-19-has-met-primary-endpoint

Read more: https://www.bloomberg.com/news/articles/2020-04-29/gilead-remdesivir-trial-for-covid-19-has-met-primary-endpoint-k9lbot69





Headline has changed and more information is being added to the link.

Gilead stock has halted!

Suspected something big was up just watching the futures.
52 replies = new reply since forum marked as read
Highlight: NoneDon't highlight anything 5 newestHighlight 5 most recent replies
Breaking News Gilead Remdesivir Trial for Covid-19 Has Met Primary Endpoint (Original Post) mobeau69 Apr 2020 OP
Good news. Of course we will soon know that tRump himself developed this drug. groundloop Apr 2020 #1
LOL. He'll look like an even bigger fool. Most people have seen the light on his con. nt mobeau69 Apr 2020 #2
If the news is true, it's still a very limited help. Requires an IV, in a hospital setting. lagomorph777 Apr 2020 #8
Could be helpful in nursing homes. LisaL Apr 2020 #11
I don't think most nursing homes are actually equipped/staffed to deliver IVs. lagomorph777 Apr 2020 #12
I guess it would have to be a skilled nursing facility. LisaL Apr 2020 #13
Yeah, it may be much more practical than sending everybody to the hospital. lagomorph777 Apr 2020 #14
Most nursing facilities KatyMan Apr 2020 #49
This is true, but at least Steelrolled Apr 2020 #27
Could any of you fill us in on what the article says? luvtheGWN Apr 2020 #3
It's everywhere now. Try this from CNBC... mobeau69 Apr 2020 #4
Try this one LiberalArkie Apr 2020 #5
Thank you. luvtheGWN Apr 2020 #15
It might help with some by just knowing they are taking something for it. Placebo effect. LiberalArkie Apr 2020 #21
We are discussing several trials on one thread. LisaL Apr 2020 #26
It was a large randomized double-blind placebo study jpak Apr 2020 #46
This message was self-deleted by its author turbinetree Apr 2020 #6
WHO messed up big time by accidently releasing incomplete data from China, (supposedly), which still_one Apr 2020 #7
That study in China was on severely sick patients. LisaL Apr 2020 #9
That is what I heard also, but still it was still an incomplete trial. I am trying to understand still_one Apr 2020 #17
They will administer the drug in an infusion center or something like that. I am skeptical still_one Apr 2020 #19
That's what I was thinking. ananda Apr 2020 #22
Yes still_one Apr 2020 #29
All anti-viral drugs must be given early to be effective. LastDemocratInSC Apr 2020 #47
The WHO release of the China study DeminPennswoods Apr 2020 #10
Still the data should not have been released because it was incomplete, also it is a still_one Apr 2020 #18
It was treatment information, released AS incomplete and Hortensis Apr 2020 #31
This latest result showed definite shorter course of the disease and that is good still_one Apr 2020 #32
Fantastic if it turns out to be reliable as research continues. Hortensis Apr 2020 #35
+++ still_one Apr 2020 #37
The "China" Remdesivir study failed to enroll enough participants BlueIdaho Apr 2020 #39
I think WHO has lost much credibility over this crisis Steelrolled Apr 2020 #25
Well, Trump has frozen U.S. funding to WHO, which is most of it Hortensis Apr 2020 #33
Realistically I don't expect anything to change Steelrolled Apr 2020 #48
not about the drugs noneof_theabove Apr 2020 #16
I want to know what "early and late" mean in these "trials........ turbinetree Apr 2020 #20
Bingo mjvpi Apr 2020 #23
What I found interesting was that when you add 62%+49% it does not equal 100 turbinetree Apr 2020 #24
It shouldn't add to a 100 % because they are talking about patients released from the hospital LisaL Apr 2020 #34
It's a real shame when positive news about development of a drug results in Hortensis Apr 2020 #28
I guess it's big pharma or something like that, and we are better off LisaL Apr 2020 #38
:) Seemingly. Of course when we finally do have medication Hortensis Apr 2020 #45
JFTR: OilemFirchen Apr 2020 #30
These companies put a lot of money and effort into drug development. LisaL Apr 2020 #36
Non-sequitur. OilemFirchen Apr 2020 #40
Would you say the same about AIDS drugs BlueIdaho Apr 2020 #41
Asked and answered above. (n/t) OilemFirchen Apr 2020 #42
So that's a yes... then... BlueIdaho Apr 2020 #43
Huh? OilemFirchen Apr 2020 #44
Yet, the British trial was NS JCMach1 Apr 2020 #50
Significance depends on the number of participants. LisaL Apr 2020 #51
I just really dislike false hope articles like the OP JCMach1 Apr 2020 #52

lagomorph777

(30,613 posts)
8. If the news is true, it's still a very limited help. Requires an IV, in a hospital setting.
Wed Apr 29, 2020, 09:40 AM
Apr 2020

Most of us REALLY don't want to get into that situation.

LisaL

(44,962 posts)
11. Could be helpful in nursing homes.
Wed Apr 29, 2020, 09:47 AM
Apr 2020

They are already in a hospital like setting with bunch of nurses around.

lagomorph777

(30,613 posts)
12. I don't think most nursing homes are actually equipped/staffed to deliver IVs.
Wed Apr 29, 2020, 09:48 AM
Apr 2020

Not the ones I've seen, anyway.

LisaL

(44,962 posts)
13. I guess it would have to be a skilled nursing facility.
Wed Apr 29, 2020, 09:51 AM
Apr 2020

Or they can invite somebody in who can administer an IV.

KatyMan

(4,147 posts)
49. Most nursing facilities
Wed Apr 29, 2020, 07:55 PM
Apr 2020

Last edited Thu Apr 30, 2020, 12:25 PM - Edit history (1)

Have a "skilled" side or skilled beds. Much of the time (at least in TX) they will contract out something as specialized as this- meaning a contracted agency would send in an RN to administer the infusions.

 

Steelrolled

(2,022 posts)
27. This is true, but at least
Wed Apr 29, 2020, 12:08 PM
Apr 2020

use of IVs is extremely common, and can be accommodated on any floor (doesn't require ICU). Hospitals have been clearing floors for COVID overflow.

luvtheGWN

(1,336 posts)
3. Could any of you fill us in on what the article says?
Wed Apr 29, 2020, 09:12 AM
Apr 2020

I've hit my limit this month for Bloomberg articles.

Thanks!

luvtheGWN

(1,336 posts)
15. Thank you.
Wed Apr 29, 2020, 09:58 AM
Apr 2020

Without a control group (as in a proper clinical trial) they really have no way of knowing if the drug helped or not. It could very well be that those who improved, would have improved without it. And since it didn't help half of the patients.........

Sorry to sound like a downer about this, but all I can say is that it's "hopeful" but definitely unproven.

LisaL

(44,962 posts)
26. We are discussing several trials on one thread.
Wed Apr 29, 2020, 11:52 AM
Apr 2020

The one where drug met primary goal had a control group taking placebo.

Response to mobeau69 (Original post)

still_one

(91,949 posts)
7. WHO messed up big time by accidently releasing incomplete data from China, (supposedly), which
Wed Apr 29, 2020, 09:33 AM
Apr 2020

did not demonstrate any difference.

One has to wonder if that released data from WHO by someone, was a manipulation


Anyway, it is good to see positive data against this virus, which hopefully has the potential to hold things at bay until a vaccine is released


LisaL

(44,962 posts)
9. That study in China was on severely sick patients.
Wed Apr 29, 2020, 09:42 AM
Apr 2020

It sounds like remdesivir has to be given early in the infection to give it a chance to work. So for severely sick patients it might be too late to get any benefits, since symptoms develop slowly overtime.
So that's when testing become so important. If you have to give the drug early, you obviously have to test quickly.
Another issue is that this drug is given via an IV, so patients would have to go into an office or clinic to get their IVs, which adds another complication.

still_one

(91,949 posts)
17. That is what I heard also, but still it was still an incomplete trial. I am trying to understand
Wed Apr 29, 2020, 10:03 AM
Apr 2020

what they mean by "early", and as you pointed out because symptoms develop overtime, testing become critical, but from my understanding, besides that they still don't have sufficient testing resources, the criteria they use in most places in order to even get the test may have to be revised


Thanks for your info Lisa


still_one

(91,949 posts)
19. They will administer the drug in an infusion center or something like that. I am skeptical
Wed Apr 29, 2020, 10:21 AM
Apr 2020

that they would administer it in an office setting, and as you said because it is given through IV, depending where people are, that may make it quite difficult for some people to get there

At least they found something that seems to help, and this might open the door to other treatments

ananda

(28,782 posts)
22. That's what I was thinking.
Wed Apr 29, 2020, 10:59 AM
Apr 2020

It's certainly better than the nothing we have so far,
except for an occasional convalescent plasma treatment.

DeminPennswoods

(15,246 posts)
10. The WHO release of the China study
Wed Apr 29, 2020, 09:45 AM
Apr 2020

apparently showed that for very, very ill patients, remdisivir didn't keep them from dying. That's a pretty high expecation for a drug, imho.

still_one

(91,949 posts)
18. Still the data should not have been released because it was incomplete, also it is a
Wed Apr 29, 2020, 10:04 AM
Apr 2020

catch 22 situation, because they need to more testing, and they need to test asymptomatic people also, because no one knows when an asymptomatic person because symptomatic in my opinion





Hortensis

(58,785 posts)
31. It was treatment information, released AS incomplete and
Wed Apr 29, 2020, 12:40 PM
Apr 2020

leaving the door open to possible efficacy in other patients.

Clinicians need to know what is known, and in the beginning nothing met the standards we would like to have.

Hortensis

(58,785 posts)
35. Fantastic if it turns out to be reliable as research continues.
Wed Apr 29, 2020, 12:52 PM
Apr 2020

Less time for the virus to implant and damage tissues.

BlueIdaho

(13,582 posts)
39. The "China" Remdesivir study failed to enroll enough participants
Wed Apr 29, 2020, 12:58 PM
Apr 2020

To reach statistical relevance. Without enough enrollees there is nothing to be learned from that study. It was abandoned prior to completion so - any and all data from that broken study are unreliable.

Other studies are continuing around the globe. Soon enough we will know - regardless of how many conspiracy theories show up on DU.

 

Steelrolled

(2,022 posts)
25. I think WHO has lost much credibility over this crisis
Wed Apr 29, 2020, 11:48 AM
Apr 2020

and the name is tainted. Maybe WHO would be better off focusing on deployment and administrative matters, out of the spotlight, and have a new international group, outside of the UN and not including politicians, be the scientific clearinghouse for the world.

Hortensis

(58,785 posts)
33. Well, Trump has frozen U.S. funding to WHO, which is most of it
Wed Apr 29, 2020, 12:48 PM
Apr 2020

of course. You may not get WHO abandoning its role right in the middle of a planet-wide pandemic, though. China's stepped in to pledge $30M to keep it going.

 

Steelrolled

(2,022 posts)
48. Realistically I don't expect anything to change
Wed Apr 29, 2020, 07:23 PM
Apr 2020

and certainly not while this pandemic is active. I have personally learned though, that positions and statements from the WHO are not necessarily based on scientific fact.

noneof_theabove

(410 posts)
16. not about the drugs
Wed Apr 29, 2020, 09:59 AM
Apr 2020

but it is all about this:

Welcome to the United Corporations and Churches of America [UCCA]
Where the real product is the Stock
and the true customer is the Stockholder.
In gawd we trust.
All others can pay foreign loan shark interest rates.

turbinetree

(24,632 posts)
20. I want to know what "early and late" mean in these "trials........
Wed Apr 29, 2020, 10:22 AM
Apr 2020
https://www.reuters.com/article/us-health-coronavirus-gilead-remdesivir/gilead-says-remdesivir-shows-improvement-in-covid-19-patients-when-used-early-idUSKBN22B1T9

where were the 397 people in the trial stages, where did they get the 62% and 49% result and did they do the following:


Physicians won’t get clarity until the medications have gone through what are known as randomized, controlled trials. In these kinds of clinical tests, half of a pool of patients is randomly given the drug, and the other half—the control group—is given an otherwise identical dosage that’s missing the active ingredient.

“If you don’t have a control, you will never know if a drug helped or harmed,” says Andre Kalil, a professor in the department of internal medicine at the University of Nebraska Medical Center.

https://www.nationalgeographic.com/science/2020/04/what-you-should-know-about-experimental-therapies-for-coronavirus/

And what about the lack of testing this country............just call me curious, what other maladies did these people have besides having the infection, did they use a placebo..................

mjvpi

(1,384 posts)
23. Bingo
Wed Apr 29, 2020, 11:26 AM
Apr 2020

Real science takes time. That’s why the 12 to 18 month window has been talked about from the beginning.

I’d be interested in who had recently purchased futures options for Gilead. When the private sector solves problems, profit is paramount to problem solving. Not to say that people working at Gilead on a cure are anything short of heroes.

turbinetree

(24,632 posts)
24. What I found interesting was that when you add 62%+49% it does not equal 100
Wed Apr 29, 2020, 11:29 AM
Apr 2020

out of the 397....................what gives.......this is suppose to be a controlled group...........

LisaL

(44,962 posts)
34. It shouldn't add to a 100 % because they are talking about patients released from the hospital
Wed Apr 29, 2020, 12:51 PM
Apr 2020

and comparing two groups in one of which patients were treated early and another where patients were treated late.
This is not even the trial where drug met the endpoint, which was a different study.

Hortensis

(58,785 posts)
28. It's a real shame when positive news about development of a drug results in
Wed Apr 29, 2020, 12:17 PM
Apr 2020

all these suspicious, negative posts. This is potentially good news, as far as it goes. The organization sponsoring the study into this drug will be making a statement, and that's probably worth holding off forming opinion for.

The Food and Drug Administration acknowledged that officials were discussing approval of remdesivir for treatment of Covid-19 patients, presumably under emergency use provisions. ... Remdesivir has never been approved as a treatment for any disease. It was developed to fight Ebola, but results from a clinical trial in Africa were disappointing.

LisaL

(44,962 posts)
38. I guess it's big pharma or something like that, and we are better off
Wed Apr 29, 2020, 12:53 PM
Apr 2020

if a deadly disease has no cure.

Hortensis

(58,785 posts)
45. :) Seemingly. Of course when we finally do have medication
Wed Apr 29, 2020, 01:33 PM
Apr 2020

that'll save our lives, that'll be new opportunity for some to rail unhappily that it was all a plot to get our money and now they have.

LisaL

(44,962 posts)
36. These companies put a lot of money and effort into drug development.
Wed Apr 29, 2020, 12:52 PM
Apr 2020

So it's pretty nice when the drug actually works, no?

LisaL

(44,962 posts)
51. Significance depends on the number of participants.
Thu Apr 30, 2020, 07:24 AM
Apr 2020

If not enough are enrolled, then you might not achieve the significant results.

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