Breaking News Gilead Remdesivir Trial for Covid-19 Has Met Primary Endpoint
Source: Bloomberg News
Gilead Sciences said it's aware of positive data emerging from the National Institute of Allergy and Infectious Diseases' study of the investigational antiviral remdesivir for the treatment of COVID-19, Bloomberg News reports.
The shares of the company are halted. More information is available on the Bloomberg Terminal.
Developing...
Update:https://www.bloomberg.com/news/articles/2020-04-29/gilead-remdesivir-trial-for-covid-19-has-met-primary-endpoint
Read more: https://www.bloomberg.com/news/articles/2020-04-29/gilead-remdesivir-trial-for-covid-19-has-met-primary-endpoint-k9lbot69
Headline has changed and more information is being added to the link.
Gilead stock has halted!
Suspected something big was up just watching the futures.
groundloop
(11,488 posts)mobeau69
(11,076 posts)lagomorph777
(30,613 posts)Most of us REALLY don't want to get into that situation.
LisaL
(44,962 posts)They are already in a hospital like setting with bunch of nurses around.
lagomorph777
(30,613 posts)Not the ones I've seen, anyway.
LisaL
(44,962 posts)Or they can invite somebody in who can administer an IV.
lagomorph777
(30,613 posts)KatyMan
(4,147 posts)Last edited Thu Apr 30, 2020, 12:25 PM - Edit history (1)
Have a "skilled" side or skilled beds. Much of the time (at least in TX) they will contract out something as specialized as this- meaning a contracted agency would send in an RN to administer the infusions.
Steelrolled
(2,022 posts)use of IVs is extremely common, and can be accommodated on any floor (doesn't require ICU). Hospitals have been clearing floors for COVID overflow.
luvtheGWN
(1,336 posts)I've hit my limit this month for Bloomberg articles.
Thanks!
mobeau69
(11,076 posts)LiberalArkie
(15,686 posts)luvtheGWN
(1,336 posts)Without a control group (as in a proper clinical trial) they really have no way of knowing if the drug helped or not. It could very well be that those who improved, would have improved without it. And since it didn't help half of the patients.........
Sorry to sound like a downer about this, but all I can say is that it's "hopeful" but definitely unproven.
LiberalArkie
(15,686 posts)LisaL
(44,962 posts)The one where drug met primary goal had a control group taking placebo.
jpak
(41,741 posts)The placebo group was the control.
Response to mobeau69 (Original post)
turbinetree This message was self-deleted by its author.
still_one
(91,949 posts)did not demonstrate any difference.
One has to wonder if that released data from WHO by someone, was a manipulation
Anyway, it is good to see positive data against this virus, which hopefully has the potential to hold things at bay until a vaccine is released
LisaL
(44,962 posts)It sounds like remdesivir has to be given early in the infection to give it a chance to work. So for severely sick patients it might be too late to get any benefits, since symptoms develop slowly overtime.
So that's when testing become so important. If you have to give the drug early, you obviously have to test quickly.
Another issue is that this drug is given via an IV, so patients would have to go into an office or clinic to get their IVs, which adds another complication.
still_one
(91,949 posts)what they mean by "early", and as you pointed out because symptoms develop overtime, testing become critical, but from my understanding, besides that they still don't have sufficient testing resources, the criteria they use in most places in order to even get the test may have to be revised
Thanks for your info Lisa
still_one
(91,949 posts)that they would administer it in an office setting, and as you said because it is given through IV, depending where people are, that may make it quite difficult for some people to get there
At least they found something that seems to help, and this might open the door to other treatments
ananda
(28,782 posts)It's certainly better than the nothing we have so far,
except for an occasional convalescent plasma treatment.
LastDemocratInSC
(3,625 posts)DeminPennswoods
(15,246 posts)apparently showed that for very, very ill patients, remdisivir didn't keep them from dying. That's a pretty high expecation for a drug, imho.
still_one
(91,949 posts)catch 22 situation, because they need to more testing, and they need to test asymptomatic people also, because no one knows when an asymptomatic person because symptomatic in my opinion
Hortensis
(58,785 posts)leaving the door open to possible efficacy in other patients.
Clinicians need to know what is known, and in the beginning nothing met the standards we would like to have.
still_one
(91,949 posts)Hortensis
(58,785 posts)Less time for the virus to implant and damage tissues.
BlueIdaho
(13,582 posts)To reach statistical relevance. Without enough enrollees there is nothing to be learned from that study. It was abandoned prior to completion so - any and all data from that broken study are unreliable.
Other studies are continuing around the globe. Soon enough we will know - regardless of how many conspiracy theories show up on DU.
Steelrolled
(2,022 posts)and the name is tainted. Maybe WHO would be better off focusing on deployment and administrative matters, out of the spotlight, and have a new international group, outside of the UN and not including politicians, be the scientific clearinghouse for the world.
Hortensis
(58,785 posts)of course. You may not get WHO abandoning its role right in the middle of a planet-wide pandemic, though. China's stepped in to pledge $30M to keep it going.
Steelrolled
(2,022 posts)and certainly not while this pandemic is active. I have personally learned though, that positions and statements from the WHO are not necessarily based on scientific fact.
noneof_theabove
(410 posts)but it is all about this:
Welcome to the United Corporations and Churches of America [UCCA]
Where the real product is the Stock
and the true customer is the Stockholder.
In gawd we trust.
All others can pay foreign loan shark interest rates.
turbinetree
(24,632 posts)where were the 397 people in the trial stages, where did they get the 62% and 49% result and did they do the following:
Physicians wont get clarity until the medications have gone through what are known as randomized, controlled trials. In these kinds of clinical tests, half of a pool of patients is randomly given the drug, and the other halfthe control groupis given an otherwise identical dosage thats missing the active ingredient.
If you dont have a control, you will never know if a drug helped or harmed, says Andre Kalil, a professor in the department of internal medicine at the University of Nebraska Medical Center.
https://www.nationalgeographic.com/science/2020/04/what-you-should-know-about-experimental-therapies-for-coronavirus/
And what about the lack of testing this country............just call me curious, what other maladies did these people have besides having the infection, did they use a placebo..................
Real science takes time. Thats why the 12 to 18 month window has been talked about from the beginning.
Id be interested in who had recently purchased futures options for Gilead. When the private sector solves problems, profit is paramount to problem solving. Not to say that people working at Gilead on a cure are anything short of heroes.
turbinetree
(24,632 posts)out of the 397....................what gives.......this is suppose to be a controlled group...........
LisaL
(44,962 posts)and comparing two groups in one of which patients were treated early and another where patients were treated late.
This is not even the trial where drug met the endpoint, which was a different study.
Hortensis
(58,785 posts)all these suspicious, negative posts. This is potentially good news, as far as it goes. The organization sponsoring the study into this drug will be making a statement, and that's probably worth holding off forming opinion for.
LisaL
(44,962 posts)if a deadly disease has no cure.
Hortensis
(58,785 posts)that'll save our lives, that'll be new opportunity for some to rail unhappily that it was all a plot to get our money and now they have.
OilemFirchen
(7,143 posts)Gilead will be releasing their earnings tomorrow.
Stay safe, investors!
LisaL
(44,962 posts)So it's pretty nice when the drug actually works, no?
OilemFirchen
(7,143 posts)But yeah, of course.
BlueIdaho
(13,582 posts)And the drug manufacturers that created them?
OilemFirchen
(7,143 posts)BlueIdaho
(13,582 posts)What a pity.
OilemFirchen
(7,143 posts)What's a pity?
JCMach1
(27,544 posts)LisaL
(44,962 posts)If not enough are enrolled, then you might not achieve the significant results.
JCMach1
(27,544 posts)When most likely the drug does little or nothing