Yes!
Feline Myotonia Congenita (MC)
Feline Myotonia Congenita (MC) is a hereditary neuromuscular disorder affecting skeletal muscles in the domestic shorthair cats. Myotonia is defined as delayed relaxation of voluntarily or reflexively contracted muscle and the term derives from Greek word ”Myo-” for muscle, and Latin word ”Tonus” for tension. The condition is classified as channelopathy, a disease caused by disturbed function of ion channel subunits of the proteins that regulate them. Myotonia congenita was first described in 1876 in a human patient, while report about feline form of the disorder did not appear until 1998. Except in humans and cats, myotonia congenita was identified in dogs, goats, horses, water buffalo and mice, and in all those species MC is associated to mutation in same gene, the CLCN1 gene. Patterns of the disorders vary from dominant to recessive, as well as the degree of its severity.
Voltage-dependent chloride (Cl–) channels are transmembrane proteins. They are critical for the normal function of skeletal muscle cells and participate in many physiological processes, such as maintenance of normal cellular excitability, the control of neurotransmitter release and the transport of ions across epithelial cells. In case of lack of sufficient functional chloride channels, the muscle fiber membrane becomes hyper-excitable and continues to be electrically active when stimulated for longer period of time than a normal muscle fiber. In this case, muscle relaxation is delayed and contraction is prolonged.
More:
http://www.animalabs.com/shop/cats/feline-myotonia-congenita-mc/
= new reply since forum marked as read
