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I noticed something many years ago
If you ever used a larger monitor than you were used to, it was almost impossible to go back to a smaller screen.
I've used 2x22' for a while and am so spoilt that it's hard to go back to one screen. I use many Adobe apps. for work, many layouts being in A1 size so it's practically essential to have a second screen for the menus, the first being for the layout I'm working on.
How you chose to configure a multi-screen config makes a difference too. My media computer has two screens configured independently but cloned. My work machine has the desktop extended over the two screens.