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Tue May 28, 2019, 02:54 PM

Broccoli and Brussels sprouts: cancer foes

Research finds compound in such cruciferous vegetables that may help to suppress tumors.

https://news.harvard.edu/gazette/story/2019/05/beth-israel-researchers-uncover-anti-cancer-drug-mechanism-in-broccoli/?

8 replies, 1103 views

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Arrow 8 replies Author Time Post
Reply Broccoli and Brussels sprouts: cancer foes (Original post)
elleng May 2019 OP
guillaumeb May 2019 #1
shraby May 2019 #2
guillaumeb May 2019 #3
elleng May 2019 #4
PoindexterOglethorpe May 2019 #5
elleng May 2019 #6
PoindexterOglethorpe May 2019 #7
Chin music May 2019 #8

Response to elleng (Original post)

Tue May 28, 2019, 03:05 PM

1. And.......

they are delicious.

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Response to guillaumeb (Reply #1)

Tue May 28, 2019, 03:15 PM

2. Yes they are!

I wonder if cabbage should be in that class of veggies.

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Response to shraby (Reply #2)

Tue May 28, 2019, 03:17 PM

3. It is.

Cabbage is also delicious in all of its forms.

Shredded, cole slaw, in stir fry.

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Response to shraby (Reply #2)

Tue May 28, 2019, 03:27 PM

4. Prolly is:

'New research has linked a compound found in Brussels sprouts, broccoli, and other cruciferous vegetables to one of the bodyís most potent tumor-suppressing genes. . .

The PTEN-protecting compound, I3C, was already known to science and thought to have anti-cancer properties, though its precise mechanism was a mystery. It occurs naturally in the cruciferous vegetables that include broccoli, Brussels sprouts, arugula, cabbage, kale, and cauliflower. That group has been investigated in the past for its cancer-fighting properties, according to the National Cancer Institute, with promising results in animal studies, but mixed results in humans.'

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Response to elleng (Original post)

Tue May 28, 2019, 04:45 PM

5. Keep in mind to get the benefits

that lab mice (not humans, this is important) got, you'd have to consume about six pounds of broccoli every day. And at that, it's not a complete magical cure. Admittedly, the article makes it seem that way with the mice, but there really aren't the kind of specific numbers that would be useful.

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Response to PoindexterOglethorpe (Reply #5)

Tue May 28, 2019, 04:50 PM

6. The article makes it clear that work has to be done:

'But for anyone encouraged by the results who wants to embark on a broccoli-eating binge, Pandolfi said thereís a chore ahead. The doses effective in laboratory mice would be the human equivalent of eating more than six pounds of broccoli daily.

From a practical standpoint, that means the most likely approach would be to develop a pill form, Pandolfi said. I3C seems to be well-tolerated by humans and is actually on the market based on anti-cancer properties exhibited in preliminary studies. Its targets arenít limited to WWP1, so additional work is needed to investigate appropriate doses and unintended effects of I3C supplements, Pandolfi said.

An alternative, albeit one that will take time, would be to develop a more narrowly targeted molecule based on I3Cís structure that zeroes in on WWP1. Pandolfi said his teamís future research will likely move in those directions.'

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Response to elleng (Reply #6)

Tue May 28, 2019, 05:02 PM

7. Right.

And my point exactly.

People always jump on preliminary research results as if they're cast in stone and as if they're vastly more meaningful than they are.

I'm okay with broccoli raw or cooked, but I don't go out of my way to eat it. And I find Brussels sprouts to be completely inedible. I guess I'll take my chances.

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Response to elleng (Reply #6)

Tue May 28, 2019, 05:21 PM

8. +1

Every bit helps.

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