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(9,484 posts)
Sat Dec 3, 2022, 03:18 PM Dec 2022

Has anyone gone through Cymbalta (Duloxetine) withdrawal?

I've been taking it for post-shingles neuralgia for a couple of years, but due to an unfortunate confluence of events, I'm facing my last daily dose tomorrow. It may be another week, or more, before I can get my prescription refilled.

I'm wondering if anyone here has gone through withdrawal after taking the med for an extended time. Sounds like I'm in for a *not good* week or so.
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Has anyone gone through Cymbalta (Duloxetine) withdrawal? (Original Post) LudwigPastorius Dec 2022 OP
Yes and it is horrible. You need to taper off, not go cold turkey. emulatorloo Dec 2022 #1
Thanks for responding. LudwigPastorius Dec 2022 #3
Of course! Hang in there and keep us posted. emulatorloo Dec 2022 #5
It was so painful I cried myself to sleep for a week. GPV Dec 2022 #2
Yikes. LudwigPastorius Dec 2022 #4
I hid in my computer room because I was so terrified of everything. emulatorloo Dec 2022 #6
Health to you shenmue Dec 2022 #7
Thanks! LudwigPastorius Dec 2022 #8
I took it over 2 years I_UndergroundPanther Dec 2022 #9
Glad you're OK. LudwigPastorius Dec 2022 #10


(44,356 posts)
1. Yes and it is horrible. You need to taper off, not go cold turkey.
Sat Dec 3, 2022, 06:08 PM
Dec 2022

Do whatever you can to get your refill as soon as possible. I suggest you call your Doc’s office ASAP and explain the situation.


(9,484 posts)
4. Yikes.
Sat Dec 3, 2022, 08:07 PM
Dec 2022

Sorry about that.

I'm in between doctors. The old one retired 6 months ago, and the earliest I can see the new one is on the 22nd.

Looks like I'm in for a nice long Monday morning on "hold" waiting to talk to somebody.


(12,605 posts)
9. I took it over 2 years
Sun Dec 4, 2022, 01:32 AM
Dec 2022

For some reason I had no withdrawal symptoms. Tapered it off. A little depression,because it has anti depressant effects. My meds got adjusted and I was ok.

My pain came back tho like it was before the cymbalta,but luckily it was time to redo my back shots.
The pain got under control.

Been off cymbalta ever since and Im doing ok.


(9,484 posts)
10. Glad you're OK.
Sun Dec 4, 2022, 02:08 PM
Dec 2022

Like most of the other things prescribed for me, cymbalta worked great for the first 6 -8 months at relieving my pain, but it has gradually been losing effectiveness since then.

It'll probably be good for me to go off of it for awhile, if I can manage the pain with Tylenol and keep from going into too deep of a mood hole.

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