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Related: About this forumTest trial suggests hallucinogenic concoction ayahuasca provides relief from depression
April 19, 2017 by Bob Yirka
(Medical Xpress)A team of researchers from several institutions in Spain and Brazil has conducted test trials of a South American concoction known as ayahuasca to learn more about its impact on people suffering from depression. In their paper uploaded to bioRxiv the team describes the trials they conducted and what they found.
Two years ago, the same team conducted some initial tests to find out if ayahuasca reduced symptoms of depressionthey reported back then that the results were promising. Seeking to expand on their work, the researchers undertook another test trial, this time enlisting the assistance of 39 volunteers, 14 of whom actually consumed the concoction, while the other 15 were given a placebo.
Ayahuasca has been known in South America for centuries, it is a beverage made by brewing two types of vines, Psychotria viridis, which contains a hallucinogenic compound, and Banisteriopsis caapi, which prevents the mind-altering compound from being broken down before it has time to pass from the gut to the brain. The result is a brew that by all accounts tastes quite nasty, and in some cases causes people to vomit. But it also induces a mind-bending experience. Anecdotal evidence has also suggested that it can improve symptoms for people suffering from depression, which led to the first and now second trial.
Each of the volunteers suffered from chronic depression, and each was asked to fill out a questionnaire regarding their mood the day before being given a single dose of ayahuasca (or an equally nasty-tasting concoction created as a placebo). On the day of dosing, each was given a small amount of ayahuasca or the placebo, and were kept in a safe room for four hours, which was how long it takes for the effects to subside. Each of the volunteers were then asked to again fill out the same questionnaire a day later, then two days later, and then a week after the trial.
Read more at: https://medicalxpress.com/news/2017-04-trial-hallucinogenic-concoction-ayahuasca-relief.html#jCp
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Test trial suggests hallucinogenic concoction ayahuasca provides relief from depression (Original Post)
Judi Lynn
Apr 2017
OP
Warpy
(114,615 posts)1. There is some clinical evidence that a Ketamine infusion
can also cause depression to lift and the effect lasts for weeks.
Unfortunately, we can't get that, either, and self dosing on the club drug doesn't work.
Too many people, especially in government, think depression and all its cousins are moral failures and that people just need to be told to snap out of it.
Until we overcome the massive ignorance out there about mood disorders, there will be no widely available treatments.
Warren DeMontague
(80,708 posts)2. Unfortunately some of the most promising substances for mind and mood
are prohibited, even from research--- because apparently citizens' brains and nervous systems are the property of the government, not themselves.
Warpy
(114,615 posts)3. Exactly
They're afraid we might work slower or something.
Warren DeMontague
(80,708 posts)4. Or worse, start laughing at authority.

Judi Lynn
(164,122 posts)5. Oh, that's so dangerous. Can't have that happening! Our fine civilization could collapse. n/t