Science
Related: About this forumScience: "SARS-CoV-2 immune evasion by the B.1.427/B.1.429 VOC" (California "epsilon")
So I guess the question is how significant a 2-3 fold reduction in neutralizing antibodies is, clinically.
(Pfizer and Moderna)
https://science.sciencemag.org/content/early/2021/06/30/science.abi7994?
A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429), originally detected in California, carries spike glycoprotein mutations S13I in the signal peptide, W152C in the N-terminal domain (NTD), and L452R in the receptor-binding domain (RBD). Plasma from individuals vaccinated with a Wuhan-1 isolate-based mRNA vaccine or convalescent individuals exhibited neutralizing titers, which were reduced 2-3.5 fold against the B.1.427/B.1.429 variant relative to wildtype pseudoviruses. The L452R mutation reduced neutralizing activity of 14 out of 34 RBD-specific monoclonal antibodies (mAbs). The S13I and W152C mutations resulted in total loss of neutralization for 10 out of 10 NTD-specific mAbs since the NTD antigenic supersite was remodeled by a shift of the signal peptide cleavage site and formation of a new disulphide bond, as revealed by mass spectrometry and structural studies.
The SARS-CoV-2 B.1.427/B.1.429 variant was reported for the first time at the beginning of 2021 in California and as of May 2021 has been detected in 34 additional countries (41, 42). The two lineages B.1.427 and B.1.429 (belonging to clade 20C according to Nextstrain designation) share the same S mutations (S13I, and W152C in the NTD and L452R in the RBD), but harbor different mutations in other SARS-CoV-2 genes (42). Molecular clock analysis suggest that the progenitor of both lineages emerged in May 2020, diverging to give rise to the B.1.427 and B.1.429 lineages in June-July 2020 (42). The fast rise in the number of cases associated with the B.1.427/B.1.429 lineages led to their classification as a VOC by the US Center for Disease Control
PA_jen
(1,114 posts)the vaccines mute against it?
intrepidity
(7,290 posts)that of neutralizing antibodies. Its mutations are in regions that are targeted by the vaccines.
It"s not clear how much difference that 2-3x means, clinically--whether the vaccines elicit such a robust immune response that the decrease won't matter.
SheltieLover
(57,073 posts)intrepidity
(7,290 posts)SheltieLover
(57,073 posts)#4 in thread here. Rhiannon graciously compiled & posted for us.
I bought 2 new boxes of 3M N95 9002s, before they sell out, after reading this.
Spoiler: delta more contageous than smallpox & cloth masks are not good enough to protect against delta!
https://www.democraticunderground.com/100215572903
Makes me extremely nervous CDC is not reporting breakthrough infections.
intrepidity
(7,290 posts)I'm aware of some of that info but not certain of source.
I have tons of masks still, and have no plans to stop using them! If for no other reason than it's been awfully nice not having even one slightest cold for over a year!
SheltieLover
(57,073 posts)Good solid sources. Let me know your thoughts.