Giving a lecture on old-timey quack medicines tomorrow

[HiPointDem]

70. The Serotonin Theory of Depression Is Collapsing

The idea that low serotonin causes depression has been repeated like a mantra by public health authorities (see movie below for a nice example). The serotonin theory of depression is a good illustration that if you repeat something enough times, people will come to believe it.

The widespread use of serotonergic drugs for treating depression and evidence for their efficacy has also greatly boosted the serotonin theory of depresion (even in the face of evidence that the beneficial drug effects are relatively modest).

But just as headaches are not caused by a lack of aspirin, the efficacy of serotonergic drugs are not a proof that depression is caused by a lack of serotonin.

As it turns out, over the past few decades, neuroscientists have had difficulty supporting the core of the theory with a demonstration that serotonin was low in depressed people. Part of the problem is that it is very difficult to measure serotonin in the brain of a live human. Studies used a variety of different assay methods and researchers had difficulty obtaining any replicable results.

In the meantime, new antidepressant drugs came on the market that had little pharmacologic effect on serotonin but had similar effiicacy as the SSRIs. This, at a miminum, suggested that the serotonin theory of depression was incomplete...

Now recent data present even more serious problems for the low serotonin theory of depression. New findings that directly contradict the core of the theory: A paper in the flagship journal, Archives of General Psychiatry found evidence of increased serotonin activity in depressed persons. Furthermore, growing evidence suggests that it is an error to even talk about the brain having a single serotonin level. Based on work with rats and mice, neuroscientists are increasingly moving to the view that there are different populations of serotonin neurons that are each independently regulated...

http://www.psychologytoday.com/blog/charting-the-depths/201007/the-serotonin-theory-depression-is-collapsing