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rog

(651 posts)
31. They are about to do a human challenge trial in the UK ...
Mon Nov 16, 2020, 05:23 PM
Nov 2020

... per Richard Engel, in his special on Covid-19 last night on MSNBC.

I didn't search far, but here is some print info that may be helpful.

https://www.nature.com/articles/d41586-020-02821-4

Dozens to be deliberately infected with coronavirus in UK ‘human challenge’ trials

Young, healthy people will be intentionally exposed to the virus responsible for COVID-19 in a first-of-its kind ‘human challenge trial’, the UK government and a company that runs such studies announced on 20 October. The experiment, set to begin in January in a London hospital if it receives final regulatory and ethical approval, aims to accelerate the development of vaccines that could end the pandemic.

Human challenge trials have a history of providing insight into diseases such as malaria and influenza. The UK trial will try to identify a suitable dose of the virus SARS-CoV-2 that could be used in future vaccine trials. But the prospect of deliberately infecting people — even those at low risk of severe disease — with SARS-CoV-2, a deadly pathogen that has few proven treatments, is uncharted medical and bioethical territory.


.rog.
There's no other way to do human studies for Phoenix61 Nov 2020 #1
Yes they can, give my family 5 million if I die or get disabled & free education I'll think about uponit7771 Nov 2020 #6
No, they can't. Turin_C3PO Nov 2020 #13
Not if they volunteer, 14,000 for human challenge (link inside) uponit7771 Nov 2020 #38
No ethical doctor would deliberately infect Phoenix61 Nov 2020 #14
No, they're doing human challenge studies here and in Europe. 14,000 already signed up here (link) uponit7771 Nov 2020 #39
No, they aren't. Phoenix61 Nov 2020 #48
I remember this story about the doctor who let a mosquito bite him & got Yellow Fever and died liberal_mama Nov 2020 #33
Yes, they were well-controlled. MineralMan Nov 2020 #2
The person speaking about Moderna on CNN claimed there was no controlled infection process ... uponit7771 Nov 2020 #3
No study can challenge subjects by deliberately exposing them to the virus. MineralMan Nov 2020 #7
They are about to do a human challenge trial in the UK ... rog Nov 2020 #31
+1, I think the number in the US is up to 14,000 already. Give them extra if they live or not uponit7771 Nov 2020 #36
Yes they can if the people volunteered link inside uponit7771 Nov 2020 #35
That was a really good article ... rog Nov 2020 #46
"both placebo group and the non placebo group both got sick but they got sick at different levels" Orangepeel Nov 2020 #15
"Usually, they will try to statistically control for other factors" True, I'm thinking they would've uponit7771 Nov 2020 #40
What you call a "controlled infection process" is very rare, and not what "control" means in tests muriel_volestrangler Nov 2020 #22
Correct, but there are 14,000 volunteers so far for human challenge. Seems like this vaccine would uponit7771 Nov 2020 #37
This - the normal kind of test - achieves different things muriel_volestrangler Nov 2020 #45
Agreed -- risk analysis or anything to strengthen claims would be nice JT45242 Nov 2020 #4
+1, "engaged in equally risky behavior." after hearing the women on CNN my jaw dropped cause the uponit7771 Nov 2020 #5
+1 Laelth Nov 2020 #8
Dexamethasone, while disagreeable to take due to moonscape Nov 2020 #20
I'm listening to the Moderna doctor and I can't believe what I'm hearing !! He's basically saying uponit7771 Nov 2020 #11
It means vaccine prevented covid in 95 % of people who got the vaccine. LisaL Nov 2020 #18
We'd have to assume the risk behavior etc etc among the two groups are equal enough ... uponit7771 Nov 2020 #28
So, yeah, they were "so wide swathed socio economically" muriel_volestrangler Nov 2020 #24
Absolutely, that's way the hell too narrow for medical vaccine. OMG, thats prelim data for further uponit7771 Nov 2020 #29
It's the number the FDA decided on a long time ago muriel_volestrangler Nov 2020 #47
It doesn't mean that at all. Disaffected Nov 2020 #30
That would assume the risk behavior etc among the groups is wide enough. I can see how this is ... uponit7771 Nov 2020 #41
People were randomly split into two groups. LisaL Nov 2020 #9
The pressers don't show delta's between the two groups that are socio economic etc uponit7771 Nov 2020 #17
Nobody would do clinical trial like that. LisaL Nov 2020 #19
Do you believe they should intentionally infect people with a deadly disease instead? Statistical Nov 2020 #10
Only if the people volunteered like have been done in human challenge studies (link inside) uponit7771 Nov 2020 #32
Many experts I respect Turin_C3PO Nov 2020 #12
+1 lunasun Nov 2020 #16
All the experts I respect are waiting on peer reviewed data which we don't have, just a presser uponit7771 Nov 2020 #21
For how long does one have immunity? I think I read moonscape Nov 2020 #23
I sincerely doubt that. LisaL Nov 2020 #25
You doubt what? Laurie Garrett, author moonscape Nov 2020 #27
The "good" news genxlib Nov 2020 #26
Hmmm, true but wouldn't that push both groups to go into higher NPI levels? Vaccine or not uponit7771 Nov 2020 #34
That is sort of the idea genxlib Nov 2020 #42
Right, I think my issue is the filing for EUA based off the 95 people so far but if it was 500 to uponit7771 Nov 2020 #43
Agreed genxlib Nov 2020 #44
That's a whole other issue with me, we can do what Thailand, Australia, S Korea or a number of other uponit7771 Nov 2020 #50
You are wrong, do more research! nt USALiberal Nov 2020 #49
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