by Astra Zeneca (which uses the same adenovirus vector). (Caused, not correlation)
The clotting disorder is strikingly similar to one known to be caused by heparin, and a mechanism has been proposed that explains the similarity between the two.
Causality is more of a journey to certainty than a binary decision, says Anthony Cox, an expert on pharmacovigilance at the University of Birmingham. But faced with accumulating cases, the European Medicines Agency (EMA), which had been careful not to point fingers, acknowledged on 7 April a probable causal association between the syndrome and the vaccine, recently named Vaxzevria.
. . .
On Friday, some of the first researchers to describe the condition published their observations in The New England Journal of Medicine. One team describes 11 patients in Germany and Austria; the other has observations on five patients in Norway. Both teams found the patients had unusual antibodies that trigger clotting reactions, which use up the bodys platelets and can block blood vessels, leading to potentially deadly strokes or embolisms.
The symptoms resemble a rare reaction to the drug heparin, called heparin-induced thrombocytopenia (HIT), in which the immune system makes antibodies to a complex of heparin and a protein called platelet factor 4 (PF4), triggering platelets to form dangerous clots throughout the body. Sickened vaccine recipients also had antibodies to PF4, the researchers found.
https://www.sciencemag.org/news/2021/04/hard-choices-emerge-link-between-astrazeneca-vaccine-and-rare-clotting-disorder-becomes