I am scheduled to return to the US from Switzerland for several weeks, beginning in late July.
Unfortunately, my airfare was prohibitively expensive; I also have one layover en route, which could make things iffy as well. I am still keeping my fingers very crossed that these reservations do not get cancelled, as they were in 2020.
I've had both Covid-19 vaccinations (Moderna), am still taking all recommended measures wrt social distancing, masking, etc. and will have to get tested for Covid-19 3-5 days before flying. It doesn't look as if I will have to be quarantined once I arrive in the US. But I may be subject to quarantine in Switzerland upon my return, depending on whatever restrictions are in force then.
If so, I've got plenty of lovely friends & neighbors who will help out if needed and groceries can be ordered on-line and delivered.
As a legal resident of Switzerland (this also grants me EU privileges), I shouldn't have other problems with flying back.
Frankly, I would not have tried to fly this year at all. But it is my spouse's 90th birthday in August. It could very likely be his last, although we are both blessed with good health, thank heavens.
Because of the pandemic we haven't seen each other in person since Jan 31, 2020.
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I wish you all the best with your visit to Italy! 
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