Lipophilic statin use linked to increased risk of dementia SOCIETY OF NUCLEAR MEDICINE AND MOLECULAR

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1. For those interested not all statins are lipophilic, the kind suspected of association with risk

and hydrophilic statins did not affect brain metabolism in the critical area.
"Patients with mild cognitive impairment or normal cognition who used lipophilic statins were found to have more than double the risk of developing dementia compared to statin non-users. Over time, PET imaging of lipophilic statin users also showed a substantial decline in metabolism in the posterior cingulate cortex, the region of the brain known to decline the most significantly in the earliest stages of Alzheimer's disease. In contrast, no clinical or metabolic decline was found for users of other statins or for statin users with higher baseline serum cholesterol levels."-- other statins are hydrophilic statins.



Lipophilic statins include atorvastatin, simvastatin, lovastatin, fluvastatin, cerivastatin and pitavastatin.
Hydrophilic statins include rosuvastatin and pravastatin.
From https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8172607/