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(121,887 posts)
58. But that wasn't your argument
Wed Aug 25, 2021, 08:51 AM
Aug 2021

You argued that there was no proof of transmission.

Multiple studies have shown that with DELTA - emphasis DELTA - some vaccinated individuals have been found to unfortunately be able to harbor enough of that viral variant than previous ones - enough to potentially be shed and infect someone else.

I think that is issue about this particular variant vs previous ones like Alpha, UK, and SA.

The suggestions have been it might be due to how the Delta variant is configured (the actual spikes), where it is apparently able to evade antibody discovery due to the folding of the proteins that make up the spike, which obscures the portion that both a vaccine and the body's immune system, can't get to.

This then allows it to go unchecked through the body for some time before being intercepted by the body's immune response, but even that is hindered because the antibodies and other components need to be able to "latch on" to specific sites on the virus to start to neutralize it.

This is probably my favorite article of late that shows what is going on with Delta - https://www.nature.com/articles/d41586-021-02039-y

In particular, here is the problem that it poses -

Since it can evade the "defense" systems, it can get in and reproduce itself rapidly (and thus you get that increased viral load) wherever it goes to find the preferred "landing sites" ("ACE2 receptors" ) in the body including the respiratory system (the nose being one area that has those receptors) - then it does this -

With Delta, a good summary is this -

“It’s clear that SARS-CoV-2 is a very fast virus that has a unique ability to prevent our immune system from recognizing and combating infection in the first stages,” says Stern-Ginossar. By the time the immune system does realize there is a virus, there is so much of it that immune-response proteins sometimes flood the bloodstream at a faster rate than normal — which can cause damage. Doctors saw early in the pandemic that some people with COVID-19 who become very ill are harmed by an overactive immune response to SARS-CoV-2, as well as by the virus itself. Some proven treatments work by dampening down this immune response.

South Korea just published a study about the potential viral load (the viral load issue also noted here and here, in different studies) that Delta has been found to generate compared to previous variants and like some of the other studies, it basically replicates faster and produces larger quantities of itself in a shorter time frame, but then starts to die down after about 10 days in its host.

The shedding from the vaccinated issues were reported by India - https://www.biorxiv.org/content/10.1101/2021.05.08.443253v5 and Finland - https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2021.26.30.2100636 PRIOR to the Provincetown and Wisconsin outbreaks as a FYI.

In essence, what was found in Wisconsin and Provincetown confirmed what was earlier found in India (the potential source of Delta) and Finland.

NatGeo has a good summary article of what they have been finding - https://www.nationalgeographic.com/science/article/evidence-mounts-that-people-with-breakthrough-infections-can-spread-delta-easily
Very smart move!!!!!!!!!!!!!!!!!!!! n/t RKP5637 Aug 2021 #1
Rig a hoop throwing game with a giant teddy bear as a prize. CrispyQ Aug 2021 #2
2 million attendees. She's definitely making the correct decision. bullwinkle428 Aug 2021 #3
Not on the day she would have gone, though. MineralMan Aug 2021 #4
I was there on the Sunday before Labor Day in 2019 (2nd last day). It was totally bullwinkle428 Aug 2021 #43
Good job LetMyPeopleVote Aug 2021 #5
Not going either. ProudMNDemocrat Aug 2021 #6
Whew. That would very likely have been disastrous. lagomorph777 Aug 2021 #7
I agree, they should cancel it. Haggard Celine Aug 2021 #8
good call imo barbtries Aug 2021 #9
There aren't enough wild horses to drag me there this year. Ocelot II Aug 2021 #10
You just enjoy the next monster truck event in safe environs True Dough Aug 2021 #27
Excellent call. Niagara Aug 2021 #11
I know I'm fighting a lonely battle on DU but Tomconroy Aug 2021 #12
I'm ignorant of the evidence provided by Major League Baseball KS Toronado Aug 2021 #13
A lot of games. A lot of crowds. No Covid outbreaks. Tomconroy Aug 2021 #15
I don't know what MLB considers an "outbreak" KS Toronado Aug 2021 #21
That's probably true, but we run some risks even in our homes, Tomconroy Aug 2021 #33
Why even take the risk under the circumstances? PufPuf23 Aug 2021 #19
But what if it actually is safe? There is real life evidence that it is. Tomconroy Aug 2021 #22
A major Spanish Flu outbreak followed a parade in Philadelphia. appleannie1 Aug 2021 #34
Th other day people were saying Obama's event was fine and the same for Lollapolooza. Treefrog Aug 2021 #35
The Obama thing was way over the top. Tomconroy Aug 2021 #37
And now Kanye has a big concert planned in Chicago with no vax requirements at all. Treefrog Aug 2021 #54
When my city (Philly) reinstituted the mask mandates a couple weeks ago BumRushDaShow Aug 2021 #38
You may be right, but to me those baseball seats look Tomconroy Aug 2021 #39
When I was looking up seat widths BumRushDaShow Aug 2021 #42
Of course the churches are indoors. I've been trying to think Tomconroy Aug 2021 #45
Don't forget that some of the data that the CDC used for recommending their changes in mask usage BumRushDaShow Aug 2021 #46
I've read the Provincetown study three times. There were many Tomconroy Aug 2021 #47
Many "outdoor" events have "indoor" components BumRushDaShow Aug 2021 #49
Actually I know virtually nothing about science or Tomconroy Aug 2021 #51
"study proves that vaccinated people can infect others with Covid. It does not do that" BumRushDaShow Aug 2021 #52
The Provincetown study was very explicit about the Tomconroy Aug 2021 #53
But that wasn't your argument BumRushDaShow Aug 2021 #58
Technically, my argument was that the Provincetown study Tomconroy Aug 2021 #59
Neither the Provincetown nor Wisconsin publications BumRushDaShow Aug 2021 #62
Which tells us a little but not too much. Tomconroy Aug 2021 #63
Consistency and validation across different populations and data sets tells QUITE a lot BumRushDaShow Aug 2021 #64
I went to a hip hop concert too. Had a great time. Tomconroy Aug 2021 #65
A "Ct" is an abbreviation for "Cycle threshold" BumRushDaShow Aug 2021 #67
Thanks for sharing. What about masks outside? ecstatic Aug 2021 #40
As far as I can tell there are no studies about masks outside. Tomconroy Aug 2021 #41
We usually go every year geardaddy Aug 2021 #14
Don't blame you a bit. paleotn Aug 2021 #16
Same issues here. There should be masks at minimum. findeerror Aug 2021 #17
Given the current status of cv19, the Minn State Fair Board most prudent step PufPuf23 Aug 2021 #18
I'd think it would be safe to hang out in the Christensen Pavilion early on a weekday. Klaralven Aug 2021 #20
I'm worried about visiting my Mom in the Twin Cities after the Great MN Superspreader Event. n/t TygrBright Aug 2021 #23
I had plans to attend a state fair, and dropped them. lindysalsagal Aug 2021 #24
Yup. I had plans to go to a show at the OC Fair. Initech Aug 2021 #32
Great choice! Dreampuff Aug 2021 #25
Masks or not, you couldn't get me near a crowded place like that MissMillie Aug 2021 #26
We just had our local Organized Labor Day picnic canceled. LiberalFighter Aug 2021 #28
👀 corn dogs and deep fried cheese curds at home?! Mersky Aug 2021 #29
Get the beef corn dogs. They cost more but worth it over the mystery meat dogs. keithbvadu2 Aug 2021 #30
There are all kinds of events going on here with cases exploding, not going anywhere. nt yaesu Aug 2021 #31
We all miss our favorite events and traditions Moebym Aug 2021 #36
Very smart move MM FakeNoose Aug 2021 #44
Some of whom are probably asymptomatic spreaders GopherGal Aug 2021 #61
But you'll miss the butter sculptures! struggle4progress Aug 2021 #48
I never liked crowds. Texaswitchy Aug 2021 #50
I love crowds and I miss them. Iggo Aug 2021 #60
Good idea about not going to the fair. panader0 Aug 2021 #55
I took my family to a county fair TheFarseer Aug 2021 #56
Update: Her Friends Also Decided Not to Go. MineralMan Aug 2021 #57
I absolutely LOVE the MN state fair. CrackityJones75 Aug 2021 #66
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