General Discussion
In reply to the discussion: I qualify for a booster shot because I'm FAT. [View all]Buckeye_Democrat
(15,526 posts)Moderna shots provided over three times as much mRNA vaccine compared to Pfizer, which is why I wanted it months ago. The reports of worse side-effects for Moderna recipients at that time didn't matter to me, especially since none of the reactions were very serious for the vast majority of people.
Is Moderna Really Better Than PfizerOr Is It Just a Higher Dose?
https://www.govexec.com/management/2021/10/moderna-really-better-pfizeror-it-just-higher-dose/186435/
... A recent (but not yet peer-reviewed) study of more than half a million U.S. veterans showed that the Johnson & Johnson shots protection against infection (whether or not that leads to disease or hospitalization) had plummeted from 88 percent to 3 percent by mid-August, while the other vaccines effectiveness had declined much less. Research published in the past few months also signals that Modernas shot beats out Pfizers in terms of both antibody count and hospitalizations prevented, while a National Institutes of Health study released earlier this month found that Modernas booster shot lifted participants antibody levels a bit more than Pfizers, and that both mRNA boosters were miles ahead of J&Js.
In light of all these data, its tempting to rank the vaccines by brand name: Moderna is better than Pfizer is better than J&J. But the same numbers hint at a different pattern: Maybe what matters most is not which vaccine you get, but how much of it.
Consider how the vaccines differ in their dosing. J&J, the least effective in the studies, has only one shot in its primary series; the mRNA vaccines have two. So anyone who got J&J (and hasnt yet gotten a booster) received half as many doses total. Comparing Pfizer with Moderna, you see another dose difference: Each shot of Pfizer contains 30 micrograms of mRNA, while each one of Moderna contains 100. (Doses for children could also differ in size: Pfizer has proposed 10-microgram shots, while Moderna is going with 50.) Just how much of the difference in the shots performance can be summed up by saying More vaccine is better?...