General Discussion

jmowreader

(53,190 posts)

58. The Marijuana Metabolic Pathway

Thu Nov 15, 2012, 07:22 PM

Nov 2012

Let's start with the basics: there is no free THC in leaf marijuana. Pot contains THC-carboxylic acid (THC-COOH). Heating the weed decarboxylates it and releases THC freebase, which is psychoactive.

When you take THC your liver metaabolizes it quickly to 11-OH-THC, which is also psychoactive, acting mainly on the parts of your brain that regulate hunger. IOW this gives you the munchies. Your liver metabolizes 11-OH-THC back to THC-COOH...but body temp isn't high enough to decarboxylate it, which is why you don't stay high for two weeks.

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With Pot Legal, Police Worry About Road Safety [View all] Seedersandleechers Nov 2012 OP

I can see it now. Fast food drive through lanes will be staked out. Major Nikon Nov 2012 #1

Anyone ordering Aerows Nov 2012 #18

LOL! Look for the ones going about 2 mph thru the fast food lanes, or parked at 7-11.... Honeycombe8 Nov 2012 #64

Knew this was going to be the problem. Pot stays Solomon Nov 2012 #2

exactly liberal_at_heart Nov 2012 #3

I don't think that's an accurate description of it, actually eShirl Nov 2012 #5

(rolls eyes). Okay. Let me say it this way then. You can Solomon Nov 2012 #6

+1. SammyWinstonJack Nov 2012 #8

-1 eShirl Nov 2012 #11

right back at you eShirl Nov 2012 #9

There are ways to test the active THC to determine if you are high. boston bean Nov 2012 #13

oh good eShirl Nov 2012 #17

let me get this straight your claiming that if one smokes a joint and tests positive a month later azurnoir Nov 2012 #22

That's not what the poster said AlexSatan Nov 2012 #46

The Marijuana Metabolic Pathway jmowreader Nov 2012 #58

Right. Because everyone reacts to pot the exact same way. randome Nov 2012 #4

My concern gollygee Nov 2012 #14

The majority of vehicular accidents have nothing to do with being under the influence argiel1234 Nov 2012 #53

This is such bullshit. Le Taz Hot Nov 2012 #7

They will stop to test all drivers pulled to the side of the road, chomping down cheetoes hlthe2b Nov 2012 #10

Total non-issue. Daemonaquila Nov 2012 #12

Agreed. Robb Nov 2012 #16

Point of information. WA State will require testing for THC ONLY eridani Nov 2012 #15

This is sily... sendero Nov 2012 #19

Speaking from observation only (not personal experience) stoned drivers demwing Nov 2012 #39

Oh, like the hardcore stoners weren't out driving before the legalization vote. marmar Nov 2012 #20

Weed is not impairing at all vanhalendlrband Nov 2012 #21

I must qualify that azurnoir Nov 2012 #24

I agree somewhat. immoderate Nov 2012 #32

A lot depends on the person LadyHawkAZ Nov 2012 #41

This 35 year toker thinks yer funny with all your bluster and bravado... cherokeeprogressive Nov 2012 #59

I know drunks that say the same thing! whistler162 Nov 2012 #61

people are already driving while stoned datasuspect Nov 2012 #23

I had the same thought. I doubt that legalization is going to result in a significant increase... slackmaster Nov 2012 #25

I don't see how everyone driving 20 mph could create any problems. n;t 2on2u Nov 2012 #26

LOL!...isn't that the truth. My friends drive so damn slow I have to "edge them on" BlueJazz Nov 2012 #54

I am more worried those that want to Secede in Texas driving 85 legally with a gun in the car graham4anything Nov 2012 #27

i wouldn't say it's "legal", because it's not unblock Nov 2012 #28

what and alcohol is much safer kydo Nov 2012 #29

as already pointed out in the thread PD Turk Nov 2012 #30

Derp WilliamPitt Nov 2012 #31

I haven't smoked pot for probably 30 years now... WCGreen Nov 2012 #33

Yeah, I would drive for hours stoned... jberryhill Nov 2012 #36

People drink and drive dem4ward Nov 2012 #34

Because no one drove when it was illegal, right? Eyes of the World Nov 2012 #35

Saw it on the TV. Jemma almost killed those poor children!! Dr Fate Nov 2012 #37

This message was self-deleted by its author devilgrrl Nov 2012 #38

Easy, the same way you treat drunks or those under the influence of meds nadinbrzezinski Nov 2012 #40

Thank You lalalu Nov 2012 #51

Right? Pot smokers drive slllooowwwww! Granny and gramps will adigal Nov 2012 #42

I think most of the drivers that they will have to worry about lexx21 Nov 2012 #43

I doubt there will be many more impaired drivers than before. Blue_In_AK Nov 2012 #44

there will not be one single additional impaired person on the road due to pnwest Nov 2012 #45

1st, the same amount of "impaired" drivers, second.. snooper2 Nov 2012 #47

I don't have the stamina to bother driving when I'm high. It's what delivery is for. n/t Pryderi Nov 2012 #48

Bullshit. Everyone who wanted to drive high already was Nevernose Nov 2012 #49

As if there are not impaired drivers littering the highway now. mick063 Nov 2012 #50

About alcohol? Blue_In_AK Nov 2012 #55

Easy. Just enforce laws that already exist against reckless driving. kestrel91316 Nov 2012 #52

The reason why some people voted against the initiative in WA was because of the DUI provision Matariki Nov 2012 #56

driving stoned is for pikers... BlueMan Votes Nov 2012 #57

If anything they should be grateful kentauros Nov 2012 #60

SWAT team aisle 12 - they just brought some brownies Smilo Nov 2012 #62

Oh please RedCappedBandit Nov 2012 #63