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In reply to the discussion: Asperger’s/Mental Illness/Gun control are Red Herrings? Adam was taking controversial drug FANAPT [View all]KoKo
(84,711 posts)(I'm a person who has had paradoxical effects from drugs. I don't like to fly and am prone to panic attacks so I got a prescription for one of the Benzodiazepine drugs. I took a pill and freaked out heading to the airport with a panic attack along with violent shaking. It was a good thing I wasn't driving. I never took another pill and stopped flying becauseit freaked me out so bad. Many years later I had an minor operation but became so agitated in the recovery room they had to hold me down because part of the the anesthesia had some derivative of a benzodiazepine in it and caused me to have a reaction. The hospital actually refunded me the money for my anethesia on my bill because I had put on my Patient information chart that I was allergic to Benzodiazepines and someone didn't check when they gave me the particular anesthesia that they did.
So this can happen. Plus both my daughter and I can't take Benedryl for colds or allergy. We both freak out instead of becoming drowsy. No one else in our family has that contrarian reaction. I found out about it when she was little and screamed all night when she was prescribed it for a mild ear ache...and years later I took it for a sinus infection (not thinking that my daughter had a former reaction) and became horribly agitated with palpitations and cold sweats.
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Paradoxical reaction
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A paradoxical reaction or paradoxical effect is an effect of medical treatment, usually a drug, opposite to the effect which would normally be expected.
An example of a paradoxical reaction is when a pain relief medication causes an increase in pain. Some sedatives prescribed for adults actually cause hyperactivity in children.
For example, there are serious complications occurring in conjunction with the use of sedatives creating a series of effects in some people, that are the total opposite of those expected. The paradoxical reactions may consist of depression, with or without suicidal tendencies, phobias, aggressiveness, violent behavior and symptoms sometimes misdiagnosed as psychosis.[1]
ONE EXAMPLE:
Benzodiazepines
Benzodiazepines, a class of psychoactive drugs called the "minor" tranquilizers, have varying hypnotic, sedative, anxiolytic, anticonvulsant, and muscle relaxing properties, but they may create the exact opposite effects. Susceptible individuals may respond to benzodiazepine treatment with an increase in anxiety, aggressiveness, agitation, confusion, disinhibition, loss of impulse control, talkativeness, violent behavior, and even convulsions. Paradoxical adverse effects may even lead to criminal behaviour.[2] Severe behavioral changes resulting from benzodiazepines have been reported including mania, schizophrenia, anger, impulsivity, and hypomania.[3] Self aggression has been reported and also demonstrated in laboratory conditions in a clinical study. Diazepam was found to increase people's willingness to harm themselves.[4] Paradoxical effects of benzodiazepines appear to be dose related, that is, likelier to occur with higher doses.[5] In a letter to the British Medical Journal, it was reported that a high proportion of parents referred for actual or threatened child abuse were taking drugs at the time, often a combination of benzodiazepines and tricyclic antidepressants. Many mothers described that instead of feeling less anxious or depressed, they became more hostile and openly aggressive towards the child as well as to other family members while consuming tranquilizers. The author warned that environmental or social stresses such as difficulty coping with a crying baby combined with the effects of tranquilizers may precipitate a child abuse event.[6] Benzodiazepines can sometimes cause a paradoxical worsening of EEG readings in patients with seizure disorders.[7] Paradoxical rage reactions due to benzodiazepines occur as a result of an altered level of consciousness, which generates automatic behaviors, anterograde amnesia and uninhibited aggression. These aggressive reactions may be caused by a disinhibiting serotonergic mechanism.[8]
http://en.wikipedia.org/wiki/Paradoxical_reaction