In the US House, she is likely to be blocked (for a long time IMHO) by an alliance of Dem leadership (both official and unofficial) working with the centrist New Democrat Coalition (now the largest single Dem caucus, as they have passed up the Progressive Caucus) and the further to the right Problem Solvers and conservative Blue Dogs.
That leaves her few options (at least for a long time) other than a run for the US Senate. She will face a tsunami of opposition centrist Dem, conservadem, Rethugs of all stripes, corrupt police unions (or as I call them, organised crime gangs), RW billionaires, AIPAC, and other assorted anti-AOC forces. It will be a brutal primary and then general election IF she chooses to go forward with a run at the Senate. IF Cuomo wins the NYC mayor race general election this fall, and IF 2028 is when AOC decides to make a run for Senate, you can be very sure that Cuomo will go all out to try and destroy her candidacy. That is one of the true underlying reasons that certain types so wanted serial sexual harasser Cuomo to win and were thrilled that he is running as a sore-loser in the general.
I do not think AOC can win a Dem POTUS primary for some time (if ever). Perhaps she could be picked as a VPOTUS running mate by some Dem POTUS primary winner, but a Dem POTUS primary winner will be under insane pressure to NOT pick her.
I think she decides to run for the US Senate. I support her 100 per cent in that. I think she is one of the best Democrats in elected office. I also know she is one of the most hated as well, and that certainly is not just limited to Rethugs and other outside of our party.
Finally, (and this is very depressing, at least for me) I also think that if she tries and fails to be elected to the US Senate OR if she decides to not even try for the US Senate, she may well withdraw from further elective politics, much to the joy of certain types both here on DU and in the real world, and much to loss of an even greater number, ie not just the ones who support her nationally and even internationally, but to the nation as a whole.
Time will tell.