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Scientists Thought Parkinson's Was in Our Genes. It Might Be in the Water (very long must-read article from Wired) [View all]
https://www.wired.com/story/scientists-thought-parkinsons-was-in-our-genes-it-might-be-in-the-water/-snip-
And this environment of yours—the sum of all your exposures, from conception to the grave—could be making you sicker than you realize. In a study of half a million Britons, Oxford researchers determined that lifestyle and the environment is 10 times more likely to explain early death than genetics. But that also offers a tantalizing prospect. If Parkinson’s is an environmental disease, as Dorsey and a small band of researchers emphatically believe, then maybe we can end it.
-snip-
After a century of putting genetics on a pedestal, the geneticists have some surprising news for us: The vast majority of chronic disease isn’t caused by our genes. “The Human Genome Project was a $3 billion investment, and what did we find out?” says Thomas Hartung, a toxicologist at Johns Hopkins. “Five percent of all disease is purely genetic. Less than 40 percent of diseases even have a genetic component.”
Most of the conditions we worry about, instead, stem from a complex interaction between our genes and our environment. Genetics loads the gun, as former National Institutes of Health head Francis Collins put it, but the environment pulls the trigger. Rather than revealing the genetic origins of disease, genomics has done the opposite. Only 10 percent of breast cancer cases are purely genetic. Chronic obstructive pulmonary disease? Rheumatoid arthritis? Coronary heart disease? All hover around 20 percent. The primary driver of disease is considerably more terrestrial: It’s the environment, stupid.
Yet only 1 percent of the roughly 350,000 chemicals in use in the United States have ever been tested for safety. In its 55-year history, the EPA has banned or restricted about a dozen (by contrast, the EU has banned more than 2,000). Paraquat, the pesticide that appears to cause Parkinson’s in farmworkers, has been banned in Europe and China but remains available in the US. And in January, a month after the EPA’s ban on TCE was finalized, the Trump administration moved to undo it, even as new evidence emerged of Parkinson’s clusters in the rust belt, where exposure to trichloroethylene is high.
-snip-
And this environment of yours—the sum of all your exposures, from conception to the grave—could be making you sicker than you realize. In a study of half a million Britons, Oxford researchers determined that lifestyle and the environment is 10 times more likely to explain early death than genetics. But that also offers a tantalizing prospect. If Parkinson’s is an environmental disease, as Dorsey and a small band of researchers emphatically believe, then maybe we can end it.
-snip-
After a century of putting genetics on a pedestal, the geneticists have some surprising news for us: The vast majority of chronic disease isn’t caused by our genes. “The Human Genome Project was a $3 billion investment, and what did we find out?” says Thomas Hartung, a toxicologist at Johns Hopkins. “Five percent of all disease is purely genetic. Less than 40 percent of diseases even have a genetic component.”
Most of the conditions we worry about, instead, stem from a complex interaction between our genes and our environment. Genetics loads the gun, as former National Institutes of Health head Francis Collins put it, but the environment pulls the trigger. Rather than revealing the genetic origins of disease, genomics has done the opposite. Only 10 percent of breast cancer cases are purely genetic. Chronic obstructive pulmonary disease? Rheumatoid arthritis? Coronary heart disease? All hover around 20 percent. The primary driver of disease is considerably more terrestrial: It’s the environment, stupid.
Yet only 1 percent of the roughly 350,000 chemicals in use in the United States have ever been tested for safety. In its 55-year history, the EPA has banned or restricted about a dozen (by contrast, the EU has banned more than 2,000). Paraquat, the pesticide that appears to cause Parkinson’s in farmworkers, has been banned in Europe and China but remains available in the US. And in January, a month after the EPA’s ban on TCE was finalized, the Trump administration moved to undo it, even as new evidence emerged of Parkinson’s clusters in the rust belt, where exposure to trichloroethylene is high.
-snip-
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