General Discussion
In reply to the discussion: New study finds no link between 'too many vaccines' and autism [View all]davidpdx
(22,000 posts)Increasing Exposure to Antibody-Stimulating Proteins and Polysaccharides in Vaccines Is Not Associated with Risk of Autism
Frank DeStefano, MD, Cristofer S. Price, and Eric S. Weintraub
Objective To evaluate the association between autism and the level of immunologic stimulation received from
vaccines administered during the first 2 years of life.
Study design We analyzed data from a case-control study conducted in 3 managed care organizations (MCOs) of
256 children with autism spectrum disorder (ASD) and 752 control children matched on birth year, sex, and MCO. In
addition to the broader category of ASD, we also evaluated autistic disorder and ASD with regression. ASD diagnoses
were validated through standardized in-person evaluations. Exposure to total antibody-stimulating proteins
and polysaccharides from vaccines was determined by summing the antigen content of each vaccine received, as
obtained from immunization registries and medical records. Potential confounding factors were ascertained from
parent interviews and medical charts. Conditional logistic regression was used to assess associations between
ASD outcomes and exposure to antigens in selected time periods.
Results The aOR (95% CI) of ASD associated with each 25-unit increase in total antigen exposure was 0.999
(0.994-1.003) for cumulative exposure to age 3 months, 0.999 (0.997-1.001) for cumulative exposure to age 7
months, and 0.999 (0.998-1.001) for cumulative exposure to age 2 years. Similarly, no increased risk was found
for autistic disorder or ASD with regression.
Conclusion In this study of MCO members, increasing exposure to antibody-stimulating proteins and polysaccharides
in vaccines during the first 2 years of life was not related to the risk of developing an ASD.
Edit: My bad, I didn't know the article was available publicly at the link posted above. I was just trying to help by posting part of the actual study so people could read it.