General Discussion
In reply to the discussion: I wrote on DU last week that my husband [View all]Th1onein
(8,514 posts)I want you to turn this over in your mind:
Survival rates for cancer are determined like this: From the time of DIAGNOSIS to the time of DEATH. Think about that. They don't talk about "cures" for cancer. They talk about survival rates, and once again, remember: Survival rate is determined by time of DIAGNOSIS to DEATH.
Now, if you know that your treatments for a disease do NOT work, and do NOT prolong survival time, what would you do, if you don't want to change those treatments, because you make a lot of money from them, but you want to INCREASE "survival"?
Come on, now, think about it. It's pretty simple--you can't stop people from dying from the disease because your treatments don't work. But there's one thing that you CAN do: Encourage EARLY DIAGNOSIS.
This has two effects: it increases the money you make from diagnostic tests, AND it increases survival time, because survival is defined as time from DIAGNOSIS to DEATH. Got it?
Now, let's talk about cancer treatments--they are THE most toxic treatments in the world, and they haven't changed much in fifty years. In fact, most chemo drugs are KNOWN carcinogens. Haven't you ever noticed how people who "beat" cancer once usually get it again? Radiation, same thing--carcinogenic.
Now, let's talk about some basic biochemistry. Remember the Krebs Cycle and the electron transport chain (oxidative phosphorylation)? You should have learned about this process in your first biology class. It's the process by which you derive energy from your food. Remember ATP? Adenosine triphosphate? It is the cellular currency for energy and every cell must make it, because every cell must have it to live.
Through the process of oxidative phosphorylation, ADP is turned into ATP. This starts out with the cleaving of glucose in the cytoplasm, which produces four molecules of ATP, but uses two molecules of ATP, so the net yield is two ATP and two pyruvate. In a cancer cell, everything stops right there. Bam, you're done.
Have you ever seen a cancer patient in cachexia? Cachexia is a big word for wasting. The cancer patient is wasting away, not because they don't take in enough nutrients. They do. But because the process by which they get their ATP is stopped at glycolysis, which takes place in the cytoplasm. This process yields four molecules of ATP, but two are used up in the process and the net yield is only two molecules of ATP, period. Not a very efficient process, so no matter how much food you take in, you're going to starve, because you're not using it efficiently.
Now, normally, the pyruvate from glycolysis goes into the mitochondria and through the process of aerobic respiration, produces 38 to 39 molecules of ATP. But, in a cancer cell, the process stops before it can get into the mitochondria. In a cancer cell, the mitochondria are turned OFF. Not only can they NOT perform the final function of turning your food into ATP, but they do it efficiently, producing 38-39 molecules of ATP. And, not only can they NOT efficiently produce this cellular currency for energy, but the mitochondria contain the instructions for cell death. NORMAL cell death. Cells are programmed to die when they are no longer viable. But cancer cells are immortal; they do not die even when they cannot perform their proper function. Because they don't have mitochondria that function properly; their mitochondria are turned OFF.
Think about that. And then think about what you could do to cause the mitochondria to turn back on. It's pretty basic. The answer is obvious: Increase pyruvate levels in the cell.
I'm not talking about anything world-shaking here. This is basic biochemistry. Very basic. Something you should learn in high school, if not your first year of college. Glycolysis, the Krebs cycle, aerobic respiration--all of it is taught early on.
As for the difference between a cancer cell and a normal cell, Warburg won the Nobel Prize for medicine way back in 1931 writing about this. The processes by which cancer is diagnosed, in fact, uses this fact--that cancer cells make their ATP by using glycolysis instead of oxidative phosphorylation--to image tumors.
WHY haven't we cured cancer then? I'll tell you why: Because cancer is an industry. That industry does not profit from cures; it profits from treating cancer as a chronic disease. I'm not talking about some massive conspiracy; I'm talking about a system that refuses to acknowledge anything except what it benefits from. That includes research, education of physicians, drug formulation and development--everything involved in the treatment of this disease, is geared towards profit, not a cure.
Recently, a doctor out of Johns Hopkins, Young Ko, found that a form of pyruvate, 3-bromopyruvate, killed cancer cells without damaging healthy cells. She is no longer at Johns Hopkins, and her work has been taken from her. 3-bromopyruvate is a very cheap, unpatentable (it's older than 20 years as a chemical) compound. It would cost less than twenty cents a day to treat a cancer patient with it and the result would be a complete cure within less than two weeks. But her collegues at Johns Hopkins filed the patent on her compound and they are now trying to "reformulate" it into a new compound that is patentable. Why would they do that, knowing that people are suffering and dying from this disease every few minutes? Well, because you can't make money from an old compound; and if you can change just a tiny piece of it, you can patent the "new" compound and make millions.
Will we ever see ANY form of pyruvate used for the treatment of cancer? Probably not in my lifetime, your lifetime, your children's lifetimes, your grandchildren's lifetimes, your great grandchildren's lifetimes, your great grandchildren's lifetimes, if ever. Why is that? Because the companies that make the toxins used to treat cancer right now just change one little molecule on their compounds whenever the patent is due to run out and come up with a "new" drug every twenty or so years!
Now, you can read this and think that I'm some kind of conspiracy nut. That's fine. Or you can read this and think that I'm some kind of nut who thinks that they've found a cure for cancer. That's fine, too. But neither of those things are true, and if you want to find out the truth, just look it up for yourself. There's nothing here that you can't research for yourself.
In the end, it's your loved ones who will die if you do nothing. Cancer rates are increasing in this country (http://www.medicalnewstoday.com/articles/246061.php "Cancer rates expected to increase by 75% by 2030"
. There's a reason for that, but I'm not going to go into it here (hint, hint: the increased glycolysis might very well be a response to the increase in glucose in our diets). In the end, it's you and your loved ones who bear the pain, and the loss.
Educate yourself. Then, DO something.