When I think of the Big Questions like The Meaning of Life and Purpose....

[el_bryanto]

5. sometimes it's best to focus on what you can do as opposed to what you have no power over.

Pangloss sometimes said to Candide:

"There is a concatenation of events in this best of all possible worlds:
for if you had not been kicked out of a magnificent castle for love of
Miss Cunegonde: if you had not been put into the Inquisition: if you had
not walked over America: if you had not stabbed the Baron: if you had
not lost all your sheep from the fine country of El Dorado: you would
not be here eating preserved citrons and pistachio-nuts."

"All that is very well," answered Candide, "but let us cultivate our
garden."

From Voltaire's Candide (I don't know what translation).