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[FarCenter]

10. Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-

Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals

While consumption of sucrose compared with HFCS-sweetened beverages induced a small increase in the 24-h insulin AUC in 34 subjects, the effects of sucrose and HFCS on 24-h circulating glucose, leptin, and ghrelin concentrations were not otherwise different. Thus, it appears that sucrose and HFCS do not have substantially different short-term effects on endocrine signals involved in body-weight regulation. Consumption of HFCS beverages also did not increase postprandial TG levels to a greater extent than those observed during consumption of sucrose-sweetened beverages.

Comparison of the effects of glucose, fructose, sucrose, and HFCS beverages within the same male subjects demonstrated that postprandial glucose and insulin responses were intermediate between the lower responses induced by pure fructose and the larger responses induced by pure glucose. Unexpectedly, the effects of short-term consumption of HFCS and sucrose on postprandial TG levels were not intermediate to those of fructose and glucose but comparable to fructose alone. Studies to determine whether these high postprandial TG levels are sustained during long-term consumption of sucrose and HFCS are needed. Additional studies in women and in subjects with and without components of the metabolic syndrome, as well as dose-response studies, are needed to more fully understand the metabolic effects of fructose-containing sugars.

http://ajcn.nutrition.org/content/87/5/1194.full
HFCS has about 10% more fructose than cane sugar, but it is not enough to matter, compared with the amount of sugar consumed as a principle cause of obesity.