General Discussion
In reply to the discussion: More on Cannabis cures cancer..... [View all]cali
(114,904 posts)that's what the quack in the OP, Mark Sircus used. duh. And it's what the person who posted that quack's article used. Me? Never. As I made more than clear, that claim, using that word, is contemptible.
you really seem to have a serious reading comprehension problem
I read the abstracts of the first three studies listed. It's precisely what I've said repeatedly in this thread: There is some evidence that cannibinoids hold some promise for treatment and it warrants further research.
Here: You seem to need some basic information quite badly. I'm happy to help you out. Read carefully and maybe you'll be able to grasp this not so complicated information. As you seem to have such difficulty in absorbing written material, I suggest that you take that valium of yours and read it a couple of times.
<snip>
Researchers first looked at the anticancer properties of cannabinoids back in the 1970s, and many hundreds of scientific papers looking at cannabinoids and cancer have been published since then.
But claims that this body of preclinical research is solid proof that cannabis or cannabinoids can cure cancer is highly misleading to patients and their families, and builds a false picture of the state of progress in this area.
Lets take a closer look at the evidence.
Lab research
Virtually all the scientific research investigating whether cannabinoids can treat cancer has been done using cancer cells grown in the lab or animal models. Its important to be cautious when extrapolating these results up to real live patients, who tend to be a lot more complex than a Petri dish or a mouse.
Through many detailed experiments, handily summarised in this recent article in the journal Nature Reviews Cancer, scientists have discovered that various cannabinoids (both natural and synthetic) have a wide range of effects in the lab, including:
Triggering cell death, through a mechanism called apoptosis
Stopping cells from dividing
Preventing new blood vessels from growing into tumours
Reducing the chances of cancer cells spreading through the body, by stopping cells from moving or invading neighbouring tissue
Speeding up the cells internal waste disposal machine a process known as autophagy which can lead to cell death
All these effects are thought to be caused by cannabinoids locking onto the CB1 and CB2 cannabinoid receptors. It also looks like cannabinoids can exert effects on cancer cells that dont involve cannabinoid receptors, although it isnt yet clear exactly whats going on there.
So far, the best results in the lab or animal models have come from using a combination of highly purified THC and cannabidiol (CBD), a cannabinoid found in cannabis plants that counteracts the psychoactive effects of THC. But researchers have also found positive results using synthetic cannabinoids, such as a molecule called JWH-133.
Its not all good news though, as theres also evidence that cannabinoids may also have undesirable effects on cancer.
For example, some researchers have found that although high doses of THC can kill cancer cells, they also harm crucial blood vessel cells, although this may help their anti-cancer effect by preventing blood vessels growing into a tumour. And under some circumstances, cannabinoids can actually encourage cancer cells to grow, or have different effects depending on the dosage and levels of cannabinoid receptors present on the cancer cells. [Edited for clarity and to add reference - KA 27/07/12]
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http://scienceblog.cancerresearchuk.org/2012/07/25/cannabis-cannabinoids-and-cancer-the-evidence-so-far/#patent
Happy reading.