Assad knew what would happen so I assume he has access to 19 subs and

[The Straight Story]

4. The Syrian Defense:

Main rundown here:
http://www.nationmaster.com/red/country/sy-syria/mil-military&all=1


It also appears that they have 2 older subs:
http://en.wikipedia.org/wiki/Syrian_Navy

Would guess with our satellite technology and such we would know the whereabouts of most their defenses that pose a direct threat to our ships and would, in an initial strike, aim to remove such defenses (using both cruise missile and bombers). We would also utilize a slew of overlay maps to best pinpoint where essential services are that maintain and support their navy (diesel subs need fuel, crews need food, etc).